Mouthwash Formulation Co-Delivering Quercetin and Mint Oil in Liposomes Improved with Glycol and Ethanol and Tailored for Protecting and Tackling Oral Cavity

Castangia, Inés; Manconi, Maria; Allaw, Mohamad; Perra, Matteo; Orrù, Germano; Fais, Sara; Scano, Alessandra; Escribano-Ferrer, Elvira; Ghavam, Mansureh; rezvani, mohammad; Manca, Maria Letizia

doi:10.3390/antiox11020367

Cited by 8 publications

(4 citation statements)

References 41 publications

(45 reference statements)

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“…These findings imply that Quercetin might be employed as a natural antibacterial agent. Future research will focus on tracing the molecular mechanism of Quercetin's antibacterial potentiality against the tested pathogens [ 20 ]. In our study, Quercetin was found to have good antibacterial activity against C. albicans , S. mutans , Lactobacillus , S. aureus , and E. faecalis at a concentration of 100 μL.…”

Section: Discussionmentioning

confidence: 99%

Formulation of Quercetin Mouthwash and Anti-microbial Potential Against Critical Pathogens: An In-Vitro Evaluation

Krishna Kumar,

Shanmugam

2024

Cureus

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Introduction Herbal mouthwashes were designed and prepared using essential oils from phytotherapeutic plants, containing active agents such as catechins, tannins, and sterols. Quercetin is one of the most abundant natural flavonoids predominantly found in foods including fruits, and vegetables. It has wide biological effects such as antioxidant, anti-aging, anti-inflammatory, probiotic, and metabolic modulation activities. Research has pointed toward its anti-microbial efficacy and bio-compatibility. Materials and methods A sample of commercially available Himalaya Hiora mouthwash (control) and 0.02 mg of Quercetin (test sample) that is sold commercially were procured. Next, 0.01 grams of sodium lauryl sulfate (SLS), which serves as the foaming agent, 0.001 grams of preservative (sodium methylparaben), and 0.3 grams of sucrose, the sweetening agent, were added to the test sample to formulate the mouthwash. We added 0.5 milliliters of the prepared Quercetin solution to the mixture. The effectiveness of the Quercetin mouthwash formulation as an antimicrobial was evaluated using the Agar-Well Diffusion Method against five oral pathogens and compared to the Hiora mouthwash. Results On quantifying the zone of inhibition, it was observed that at 100 μL of concentration, Staphylococcus aureus shows maximum inhibition rate, i.e., 15 mm when compared to commercially available herbal mouthwash (Himalaya Hiora). Thus, from the results obtained, we found that when concentration increases there is a significant zone of inhibition shown by oral pathogens. Conclusion Quercetin mouthwash formulation has proven to have a good antimicrobial effect when compared to standard mouthwash. The effective antimicrobial activity suggests its potential use as an adjuvant chemical plaque control modality. Further clinical trials would pave the way for its use as a routine or therapeutic antimicrobial agent.

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Section: Discussionmentioning

confidence: 99%

Formulation of Quercetin Mouthwash and Anti-microbial Potential Against Critical Pathogens: An In-Vitro Evaluation

Krishna Kumar,

Shanmugam

2024

Cureus

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“…The Zetasizer Ultra was used as well to detect the surface charge of vesicles (zeta potential) measuring their electrophoretic mobility in dispersion by the mixed-mode measurement-phase analysis (M3-PALS). Each sample was diluted with water (1:100) to be optically clear and to avoid the attenuation of the laser beam by the particles along with the reduction of scattered light that can be detected [ 21 ].…”

Section: Methodsmentioning

confidence: 99%

From Grape By-Products to Enriched Yogurt Containing Pomace Extract Loaded in Nanotechnological Nutriosomes Tailored for Promoting Gastro-Intestinal Wellness

et al. 2023

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Grape pomace is the main by-product generated during the winemaking process; since it is still rich in bioactive molecules, especially phenolic compounds with high antioxidant power, its transformation in beneficial and health-promoting foods is an innovative challenge to extend the grape life cycle. Hence, in this work, the phytochemicals still contained in the grape pomace were recovered by an enhanced ultrasound assisted extraction. The extract was incorporated in liposomes prepared with soy lecithin and in nutriosomes obtained combining soy lecithin and Nutriose FM06®, which were further enriched with gelatin (gelatin-liposomes and gelatin-nutriosomes) to increase the samples’ stability in modulated pH values, as they were designed for yogurt fortification. The vesicles were sized ~100 nm, homogeneously dispersed (polydispersity index < 0.2) and maintained their characteristics when dispersed in fluids at different pH values (6.75, 1.20 and 7.00), simulating salivary, gastric and intestinal environments. The extract loaded vesicles were biocompatible and effectively protected Caco-2 cells against oxidative stress caused by hydrogen peroxide, to a better extent than the free extract in dispersion. The structural integrity of gelatin-nutriosomes, after dilution with milk whey was confirmed, and the addition of vesicles to the yogurt did not modify its appearance. The results pointed out the promising suitability of vesicles loading the phytocomplex obtained from the grape by-product to enrich the yogurt, offering a new and easy strategy for healthy and nutritional food development.

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“…The dispersion phase was made using a mixture of phosphate buffer, propylene glycol, and ethanol, whereas the bilayers were made using soy lecithin and Tween 80. Streptococcus mutans and Lactobacillus acidophilus growth was inhibited in the presence of the vesicles, showing their effectiveness [ 85 ].…”

Section: Que Nanosystemsmentioning

confidence: 99%

Recent Advances in Nanoformulations for Quercetin Delivery

et al. 2023

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Quercetin (QUE) is a flavonol that has recently received great attention from the research community due to its important pharmacological properties. However, QUE’s low solubility and extended first-pass metabolism limit its oral administration. This review aims to present the potential of various nanoformulations in the development of QUE dosage forms for bioavailability enhancement. Advanced drug delivery nanosystems can be used for more efficient encapsulation, targeting, and controlled release of QUE. An overview of the primary nanosystem categories, formulation processes, and characterization techniques are described. In particular, lipid-based nanocarriers, such as liposomes, nanostructured-lipid carries, and solid-lipid nanoparticles, are widely used to improve QUE’s oral absorption and targeting, increase its antioxidant activity, and ensure sustained release. Moreover, polymer-based nanocarriers exhibit unique properties for the improvement of the Absorption, Distribution, Metabolism, Excretion, and Toxicology (ADME(T)) profile. Namely, micelles and hydrogels composed of natural or synthetic polymers have been applied in QUE formulations. Furthermore, cyclodextrin, niosomes, and nanoemulsions are proposed as formulation alternatives for administration via different routes. This comprehensive review provides insight into the role of advanced drug delivery nanosystems for the formulation and delivery of QUE.

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Mouthwash Formulation Co-Delivering Quercetin and Mint Oil in Liposomes Improved with Glycol and Ethanol and Tailored for Protecting and Tackling Oral Cavity

Cited by 8 publications

References 41 publications

Formulation of Quercetin Mouthwash and Anti-microbial Potential Against Critical Pathogens: An In-Vitro Evaluation

Formulation of Quercetin Mouthwash and Anti-microbial Potential Against Critical Pathogens: An In-Vitro Evaluation

From Grape By-Products to Enriched Yogurt Containing Pomace Extract Loaded in Nanotechnological Nutriosomes Tailored for Promoting Gastro-Intestinal Wellness

Recent Advances in Nanoformulations for Quercetin Delivery

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