Mouse Flk-1+Sca-1- Mesenchymal Stem Cells

Abstract

Flk-1Sca-1 bMSCs have stem cell properties and can efficiently ameliorate the GVHD associated with allogeneic bone marrow transplantation in mice.

Mesenchymal stem cells provide prophylaxis against acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation: A meta-analysis of animal models

“…Five studies reported that animals were randomly assigned to an MSC or control group [ 13 , 19 , 33 , 38 , 44 ], and four studies indicated that the assessors were blinded to outcomes [ 15 , 45 , 53 , 58 ]. The majority of the included studies reported compliance with animal welfare requirements and conflict of interest statements.…”

“…There was significant heterogeneity among the studies (I 2 = 66.1%, P = 2.12×10 −18 ) (Figure 1 ). In addition, 29 studies involving 41 comparisons examined the effect of MSCs on aGVHD-associated clinical scores [ 14 , 15 , 17 , 19 , 20 , 22 , 24 , 27 , 28 , 33 , 34 , 36 – 39 , 42 , 44 , 46 , 47 , 49 – 52 , 55 , 57 – 59 , 61 , 62 ]. The pooled analysis indicated that aGVHD-associated clinical scores were significantly lower in the MSC groups than in the control groups (SMD = −3.60, 95% CI −4.43 to −2.76, P = 3.61×10 −17 ) (Figure 2 ).…”