Motor resonance mechanisms are preserved in Alzheimer’s disease patients

Bisio, Ambra; Casteran, Matthieu; Ballay, Yves; Manckoundia, Patrick; Mourey, France; Pozzo, Thierry

doi:10.1016/j.neuroscience.2012.07.017

Cited by 18 publications

(22 citation statements)

References 60 publications

(88 reference statements)

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“…In implicit task, HC pointing velocities varied as a consequence of the stimuli velocities, suggesting an intact ability to automatically match the perceived kinematics with brain action representation, as already shown in previous studies on both young and elderly healthy participants [20,24]. As expected, imitation performance was improved when HC was explicitly instructed to reproduce the stimulus velocity.…”

Section: Kinematic Features Of the Participants' Pointing Movement Insupporting

confidence: 77%

“…The task is a modified version of that described in previous studies of our group [20,23,24]. All participants were seated in a darkened room in front of a large rear projection screen (170*230) placed 10 cm beyond the end of participants' extended arm.…”

Section: Movement Tasksmentioning

confidence: 99%

“…However, difficulties in conceptualizing and assessing social responsivity and empathic-Research Article Djamila Bennabi of resonance can be diminished in psychiatric disorders such as autism [13], schizophrenia and personality disorders such as psychopathy [14][15][16][17][18]. Assessing empathic abilities with resonance tasks can reveal spontaneous behavioral reactions reflecting daily-life social skills independently of participants' intellectual abilities, since processing at this level is characterized by being fast, implicit and domain specific [19,20]. In the current study, we evaluated the sensorimotor mechanisms underlying motor resonance by employing a simple imitation paradigm.…”

Section: Introductionmentioning

confidence: 99%

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Motor Resonance Mechanisms during Action Imitation in Depression

Bennabi¹,

Carvalho²,

Bisio³

et al. 2018

Neuropsychiatry

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Major depressive disorder has been associated with impairments in social cognition. However, studies exploring the processing of social information focused on facial discrimination. The aim of this study was to better characterize the sensorimotor mechanisms underlying motor resonance in depressed patients. Method Twenty-three right-handed patients meeting DSM-IV criteria for unipolar depression were compared to 14 matched healthy controls. In a simple imitation paradigm, the kinematic features of movements in natural condition were compared to those of motions performed after the observation of a moving dot. Reaction time and pointing velocity were considered to evaluate if the motor performance was contaminated by the observed stimulus. Results Patient's velocity varied in agreement with dot velocity, proving that they were able to extract the correct information from the stimuli and use it to plan their responses. Depressed patients' actions, as well as healthy controls, were influenced by the dot velocity, suggesting that motor resonance mechanisms are not prevented by depression. In contrast, only patients had anticipatory motor response and started moving before the end of the stimulus motion. Conclusion Our findings suggest that motor resonance mechanisms are not altered by the disease. However, depressed patients exhibit a specific deficit in motor inhibition in the selection of motor responses.

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Section: Kinematic Features Of the Participants' Pointing Movement Insupporting

confidence: 77%

Section: Movement Tasksmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Motor Resonance Mechanisms during Action Imitation in Depression

Bennabi¹,

Carvalho²,

Bisio³

et al. 2018

Neuropsychiatry

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show abstract

“…To quantify the occurrence of motor contagion we used the same procedure already applied in our previous studies [24], [28] and we considered movement mean velocity (V) as outcome parameter. Thus, we tested if the velocity of the visual model influenced participants' velocity.…”

Section: Methodsmentioning

confidence: 99%

“…Participants were requested either to move their hands into a pre-specified final position or to put an object into a container after they had seen the demonstrator performing the same task at various execution velocities. We measured the degree of motor contagion (i.e., how much participants' velocity was affected by demonstrator' velocity), considering that the more motor resonance is evoked, the more participants' motor response is influenced by the observed motion [24], [28]. If the activation of the motor resonance mechanisms relies mostly on the possibility to match the observer's motor repertoire with that of the visual model, motor contagion will appear in all conditions, irrespective of the nature of the demonstrator (human/robot) and the shape of the covered trajectory (smooth-curvilinear/jerky-artificial), but will be absent when the demonstrator exhibits non-biological kinematics.…”

Section: Introductionmentioning

confidence: 99%

Motor Contagion during Human-Human and Human-Robot Interaction

et al. 2014

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Motor resonance mechanisms are known to affect humans' ability to interact with others, yielding the kind of “mutual understanding” that is the basis of social interaction. However, it remains unclear how the partner's action features combine or compete to promote or prevent motor resonance during interaction. To clarify this point, the present study tested whether and how the nature of the visual stimulus and the properties of the observed actions influence observer's motor response, being motor contagion one of the behavioral manifestations of motor resonance. Participants observed a humanoid robot and a human agent move their hands into a pre-specified final position or put an object into a container at various velocities. Their movements, both in the object- and non-object- directed conditions, were characterized by either a smooth/curvilinear or a jerky/segmented trajectory. These trajectories were covered with biological or non-biological kinematics (the latter only by the humanoid robot). After action observation, participants were requested to either reach the indicated final position or to transport a similar object into another container. Results showed that motor contagion appeared for both the interactive partner except when the humanoid robot violated the biological laws of motion. These findings suggest that the observer may transiently match his/her own motor repertoire to that of the observed agent. This matching might mediate the activation of motor resonance, and modulate the spontaneity and the pleasantness of the interaction, whatever the nature of the communication partner.

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Mirror neurons and their relationship with neurodegenerative disorders

Farina

Borgnis

Pozzo

2020

J of Neuroscience Research

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The finding of mirror neurons (MNs) has provided a biological substrate to a new concept of cognition, relating data on actions and perceptions not only to integrate perception in action planning and execution but also as a neural mechanism supporting a wide range of cognitive functions. Here we first summarize data on MN localization and role in primates, then we report findings in normal human subjects: functional magnetic resonance imaging and neurophysiological studies sustain that MNs have a role in motor learning and recognizing actions and intentions of others, and they also support an embodied view of language, empathy, and memory. Then, we detail the results of literature searching on MNs and embodied cognition in Parkinson's disease (PD), frontotemporal dementia (FTD)/amyotrophic lateral sclerosis (ALS), and in mild cognitive impairment (MCI)/Alzheimer's disease (AD). In PD the network of MN could be altered, but its hyperactivation might support motor and cognitive performances at least in early stages. In the ALS/FTD continuum, preliminary evidence points out to an involvement of the MN network, which could explain language and inter-subjectivity deficits shown in patients affected by these clinical entities. In the MCI/ AD spectrum, a few recent studies suggest a possible progressive involvement from posterior to anterior areas of the MN network, with the brain putting in place compensatory mechanisms in early stages. Reinterpreting neurodegenerative diseases at the light of the new views about brain organization stemming from the discovery of MN could help to better comprehend clinical manifestations and open new pathways to rehabilitation. K E Y W O R D S Alzheimer's disease, amyotrophic lateral sclerosis, embodied cognition, frontotemporal dementia, mirror neurons, Parkinson's disease | 1071 FARINA et Al.

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Motor resonance mechanisms are preserved in Alzheimer’s disease patients

Cited by 18 publications

References 60 publications

Motor Resonance Mechanisms during Action Imitation in Depression

Motor Resonance Mechanisms during Action Imitation in Depression

Motor Contagion during Human-Human and Human-Robot Interaction

Mirror neurons and their relationship with neurodegenerative disorders

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