Motor Control in Infants with Down Syndrome

Rast, Mechthild M.; Harris, Susan R.

doi:10.1111/j.1469-8749.1985.tb14144.x

Cited by 22 publications

(10 citation statements)

References 2 publications

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“…Children with DS usually walk at a slower speed, and produce a shorter step length and a wider step width. 9,10 This is due to their musculoskeletal and neuromuscular deficits such as decreased muscle strength, 11 hypotonia, 12 and increased muscle burst onset latencies. 13 As infants with DS can repeatedly practice alternating stepping patterns (a pattern similar to that of overground walking) and improve their leg muscle strength and limb coordination during treadmill training, they should produce more advanced gait patterns within a certain period after the training ends.…”

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confidence: 99%

Exploring effects of different treadmill interventions on walking onset and gait patterns in infants with Down syndrome

Looper

Ulrich

et al. 2007

Develop Med Child Neuro

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Two cohorts of participants were included to investigate the effects of different treadmill interventions on walking onset and gait patterns in infants with Down syndrome (DS). The first cohort included 30 infants with DS (17 males, 13 females; mean age 10mo [SD 1.9mo]) who were randomly assigned to either a lower‐intensity‐generalized (LG) training group, or a higher‐intensity‐individualized (HI) training group. A control (C) group from another study, who did not receive treadmill training, served as the control (eight males, seven females; mean age 10.4mo [SD 2.2mo]). Mean age at walking onset was 19.2, 21.4, and 23.9 months for the HI, LG, and C groups respectively. At walking onset the HI group was significantly younger than the C group (p=0.011). At the gait follow‐up that was conducted between 1 and 3 months after walking onset, three groups significantly different in overall gait patterns (p=0.037) were examined by six basic gait parameters including average velocity, stride length, step width, stride time, stance time, and dynamic base. Post‐hoc analyses demonstrated that stride length was the gait parameter largely contributing to this overall group difference (p=0.033), and the HI group produced a significantly longer stride length than the C group (p=0.030). In conclusion, the HI treadmill intervention significantly promoted earlier walking onset and elicited more advanced gait patterns (particularly in stride length) in infants with DS.

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confidence: 99%

Exploring effects of different treadmill interventions on walking onset and gait patterns in infants with Down syndrome

Looper

Ulrich

et al. 2007

Develop Med Child Neuro

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“…28 Although the majority of previous studies focused on the acquisition of motor milestones such as rolling from supine to prone, sitting, and head control, and a few studies have addressed postural control in DS, 11,12 few longitudinal studies followed the same group of children. 29,30 Recently, Tudella et al 13 Copyright © 2015 Wolters Kluwer Health, Inc. and the Section on Pediatrics of the American Physical Therapy Association.…”

Section: Discussionmentioning

confidence: 99%

“…Regarding early postural control, crosssectional studies have shown that head righting, protective reactions, and other responses are also impaired. 11,12 In addition, longitudinal studies have demonstrated that the acquisition of motor skills, especially midline behaviors 13 and vertical postures, 14 is often delayed. Later in childhood, the acquisition of gross motor skills such as walking and running also occurs later in children with DS compared with children with TD.…”

Section: Introduction and Purposementioning

confidence: 99%

Motor Performance of Children With Down Syndrome and Typical Development at 2 to 4 and 26 Months

Cardoso

Campos

Santos

et al. 2015

Pediatric Physical Therapy

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“…Motor skill development appear to show the same developmental delays as these early markers of motor abilities (Connolly & Michael, 1986;U. Frith & Frith, 1974;Gemus et al, 2002;Rast & Harris, 1985;Vicari, 2006;Virji-Babul et al, 2006).…”

Section: Introductionmentioning

confidence: 89%

Adaptation of the Arizona Cognitive Task Battery for use with the Ts65Dn Mouse Model (Mus musculus) of Down syndrome

Hunsaker

Smith

Kesner

2016

Preprint

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We propose and validate a clear strategy to efficiently and comprehensively characterize neurobehavioral deficits in the Ts65Dn mouse model of Down syndrome. This novel approach uses neurocognitive theory to design and select behavioral tasks that test specific hypotheses concerning the results of Down syndrome. In this manuscript we model in Ts65Dn mice the Arizona Cognitive Task Battery used to study human populations with Down syndrome. We observed specific deficits for spatial memory, impaired long-term memory for visual objects, acquisition and reversal of motor responses, reduced motor dexterity, and impaired adaptive function as measured by nesting and anxiety tasks. The Ts65Dn mice showed intact temporal ordering, novelty detection, and visual object recognition with short delays. These results phenocopy the performance of participants with Down syndrome on the Arizona Cognitive Task Battery. This approach extends the utility of mouse models of Down syndrome by integrating the expertise of clinical neurology and cognitive neuroscience into the mouse behavioral laboratory. Further, by directly emphasizing the reciprocal translation of research between human disease states and the associated mouse models, we demonstrate that it is possible for both groups to mutually inform each others’ research to more efficiently generate hypotheses and elucidate treatment strategies.

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Motor Control in Infants with Down Syndrome

Cited by 22 publications

References 2 publications

Exploring effects of different treadmill interventions on walking onset and gait patterns in infants with Down syndrome

Exploring effects of different treadmill interventions on walking onset and gait patterns in infants with Down syndrome

Motor Performance of Children With Down Syndrome and Typical Development at 2 to 4 and 26 Months

Adaptation of the Arizona Cognitive Task Battery for use with the Ts65Dn Mouse Model (Mus musculus) of Down syndrome

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