Survival and longevity rates in people living with HIV (HIV+) have increased with the availability and use of antiretroviral therapy (ART). However, despite the above HIV+ adults treated with ART have a higher risk of developing dyslipidemia and high waist circumference. In addition, they have lower cardiorespiratory fitness, loss of muscle mass, reduced balance, and reduced functional capacity, which affects their quality of life. To explore the impact of balance perception, treadmill time, grip strength, body mass index (BMI), and waist-to-height ratio (WHtR) on quality of life in Latino Hispanic people living with HIV. This study recruited twenty-five participants from a community-based center, La Perla de Gran Precio, in San Juan, Puerto Rico, with the medical diagnosis of HIV. Descriptive measures were obtained for all variables of interest, and correlation and regression analyses were used to assess the associations between functional capacity, quality of life, and anthropometric measures. Result: Men had greater left- and right-hand grip strength than women (86.9±18.8, 56.9±26.8 kg; p=0.003 and 87.6±15.1 vs. 61.4±26.6 kg; p =0.004). Two anthropometric variables showed a trend toward a moderate positive correlation with quality of life: WHtR (r= -0.38, p =0.12) and BMI (r= -0.38, p = p-0.14). Although gender differences in upper body strength are expected, handgrip strength is within the gender-specific average range of the general population. The integration of anthropometric characteristics and upper body strength when prescribing exercise must be considered since these factors influence functional capacity and quality of life among HIV+ adults.