“…The activation of the pituitary-adrenal system in response to stress in general (Selye, 1956) and to the avoidance situation in particular has been established and discussed by several authors (see Brush & Froelich, 1975;Di Giusto, Cairncross, & King, 1971;Gray, 1971; Leshner, 1978; Levine, 1971). Coover, Ursin, and Levine (1973) proposed that graded elevations in plasma corticosterone follow aversive stimulation and can serve as an appropriate indicator of the associated arousal levels of the animal.…”