ABSTRACT

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Rat and frog adrenal glands incubated in Krebs-Ringer bicarbonate glucose solution convert added 11\g=b\-hydroxyprogesterone to corticosterone more efficiently than added deoxycorticosterone. Up to 36% of the added 11\g=b\-hydroxyprogesterone incubated with rat adrenal glands was accounted for by the increase in the corticosterone fraction. Adrenals from both animals also metabolized 11\g=b\-hydroxyprogesterone to fractions with the mobility of aldosterone and 18-hydroxycorticosterone. These findings suggest that 11\g=b\-hydroxyprogesterone may play a significant role in corticoid synthesis.In previous work on the biosynthesis of rat adrenal steroids it was found that 18-hydroxy-ll-deoxycorticosterone (18-OH-DOC)3 could arise from deoxy-1. Graduate Student,