Motion-corrected 4D-Flow MRI for neurovascular applications

Rivera‐Rivera, Leonardo A.; Kecskemeti, Steve; Jen, Mu-Lan; Miller, Zachary; Johnson, Sterling C.; Eisenmenger, Laura; Johnson, Kevin M.

doi:10.1016/j.neuroimage.2022.119711

Cited by 3 publications

(2 citation statements)

References 45 publications

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“…127,128 Recently, 3D-radials have been used for rigid head motion correction in neurovascular 4D flow of geriatric populations. 129,130 The utilization of radials for 4D CSF flow imaging has been considerably less studied. Figure 9 shows an example of magnitude and velocity images derived from 4D CSF flow data in a healthy volunteer using spiral (A) and radial (B) readouts.…”

Section: Low Velocities Associated With Csf Motionmentioning

confidence: 99%

“…In radial readouts, oversampling of the center of k‐space and reasonable undersampling of higher k‐space frequencies results in benign streak artifacts, and can be utilized for self‐navigation and bulk motion correction 127,128 . Recently, 3D‐radials have been used for rigid head motion correction in neurovascular 4D flow of geriatric populations 129,130 . The utilization of radials for 4D CSF flow imaging has been considerably less studied.…”

Section: D Csf Flow Imagingmentioning

confidence: 99%

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Four‐dimensional flow MRI for quantitative assessment of cerebrospinal fluid dynamics: Status and opportunities

Rivera‐Rivera,

Vikner,

Eisenmenger

et al. 2023

NMR in Biomedicine

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Neurological disorders can manifest with altered neurofluid dynamics in different compartments of the central nervous system. These include alterations in cerebral blood flow, cerebrospinal fluid (CSF) flow, and tissue biomechanics. Noninvasive quantitative assessment of neurofluid flow and tissue motion is feasible with phase contrast magnetic resonance imaging (PC MRI). While two‐dimensional (2D) PC MRI is routinely utilized in research and clinical settings to assess flow dynamics through a single imaging slice, comprehensive neurofluid dynamic assessment can be limited or impractical. Recently, four‐dimensional (4D) flow MRI (or time‐resolved three‐dimensional PC with three‐directional velocity encoding) has emerged as a powerful extension of 2D PC, allowing for large volumetric coverage of fluid velocities at high spatiotemporal resolution within clinically reasonable scan times. Yet, most 4D flow studies have focused on blood flow imaging. Characterizing CSF flow dynamics with 4D flow (i.e., 4D CSF flow) is of high interest to understand normal brain and spine physiology, but also to study neurological disorders such as dysfunctional brain metabolite waste clearance, where CSF dynamics appear to play an important role. However, 4D CSF flow imaging is challenged by the long T1 time of CSF and slower velocities compared with blood flow, which can result in longer scan times from low flip angles and extended motion‐sensitive gradients, hindering clinical adoption. In this work, we review the state of 4D CSF flow MRI including challenges, novel solutions from current research and ongoing needs, examples of clinical and research applications, and discuss an outlook on the future of 4D CSF flow.

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Section: Low Velocities Associated With Csf Motionmentioning

confidence: 99%

Section: D Csf Flow Imagingmentioning

confidence: 99%

Four‐dimensional flow MRI for quantitative assessment of cerebrospinal fluid dynamics: Status and opportunities

Rivera‐Rivera,

Vikner,

Eisenmenger

et al. 2023

NMR in Biomedicine

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Editorial for “Cerebral Sinus Hemodynamics in Adults Revealed by 4D Flow MRI”

Aramendía‐Vidaurreta,

Dux‐Santoy

2024

Magnetic Resonance Imaging

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Unraveling diurnal and technical variability in cerebral hemodynamics from neurovascular 4D-Flow MRI

Rivera-Rivera,

Roberts,

Peret

et al. 2024

J Cereb Blood Flow Metab

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Neurovascular 4D-Flow MRI enables non-invasive evaluation of cerebral hemodynamics including measures of cerebral blood flow (CBF), vessel pulsatility index (PI), and cerebral pulse wave velocity (PWV). 4D-Flow measures have been linked to various neurovascular disorders including small vessel disease and Alzheimer’s disease; however, physiological and technical sources of variability are not well established. Here, we characterized sources of diurnal physiological and technical variability in cerebral hemodynamics using 4D-Flow in a retrospective study of cognitively unimpaired older adults (N = 750) and a prospective study of younger adults (N = 10). Younger participants underwent repeated MRI sessions at 7am, 4 pm, and 10 pm. In the older cohort, having an MRI earlier on the day was significantly associated with higher CBF and lower PI. In prospective experiments, time of day significantly explained variability in CBF and PI; however, not in PWV. Test-retest experiments showed high CBF intra-session repeatability (repeatability coefficient (RPC) =7.2%), compared to lower diurnal repeatability (RPC = 40%). PI and PWV displayed similar intra-session and diurnal variability (PI intra-session RPC = 22%, RPC = 24% 7am vs 4 pm; PWV intra-session RPC = 17%, RPC = 21% 7am vs 4 pm). Overall, CBF measures showed low technical variability, supporting diurnal variability is from physiology. PI and PWV showed higher technical variability but less diurnal variability.

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Motion-corrected 4D-Flow MRI for neurovascular applications

Cited by 3 publications

References 45 publications

Four‐dimensional flow MRI for quantitative assessment of cerebrospinal fluid dynamics: Status and opportunities

Four‐dimensional flow MRI for quantitative assessment of cerebrospinal fluid dynamics: Status and opportunities

Editorial for “Cerebral Sinus Hemodynamics in Adults Revealed by 4D Flow MRI”

Unraveling diurnal and technical variability in cerebral hemodynamics from neurovascular 4D-Flow MRI

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