Mother's smoking and complex lung function of offspring in middle age: A cohort study from childhood

Perret, Jennifer L; Walters, E. Haydn; Johns, DP; Gurrin, Lyle C.; Burgess, John A.; Lowe, Adrian J.; Thompson, Bruce; Markos, James; Morrison, Stephen; Thomas, Paul S.; McDonald, Christine F; Wood‐Baker, Richard; Hopper, John L.; Svanes, Cecilie; Giles, Graham G.; Abramson, Michael J.; Matheson, Melanie C.; Dharmage, Shyamali C.

doi:10.1111/resp.12750

Cited by 34 publications

(44 citation statements)

References 31 publications

(47 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Consistent with the current literature, we found that maternal tobacco smoking during pregnancy had negative effects on children's lung function. Many epidemiological studies have indicated an adverse effect of maternal tobacco smoking on the lung health of infants and children . Our findings further highlight the need for smoking cessation support for parents, from the preconception period and onwards, to improve their children's respiratory health.…”

Section: Discussionsupporting

confidence: 59%

Early life exposure to coal mine fire smoke emissions and altered lung function in young children

et al. 2019

Self Cite

View full text Add to dashboard Cite

Background and objective Long‐term respiratory risks following exposure to relatively short periods of poor air quality early in life are unknown. We aimed to evaluate the association between exposure to a 6‐week episode of air pollution from a coal mine fire in children aged <2 years, and their lung function 3 years after the fire. Methods We conducted a prospective cohort study. Individual exposure to 24‐h average and peak concentrations of particulate matter with an aerodynamic diameter <2.5 μm in diameter (PM2.5) during the fire were estimated using dispersion and chemical transport modelling. Lung function was measured using the forced oscillation technique (FOT), generating standardized Z‐scores for resistance and reactance at a frequency of 5 Hz (Rrs5 and Xrs5), and area under the reactance curve (AX). We used linear regression models to assess the associations between PM2.5 exposure and lung function, adjusted for potential confounders. Results Of the 203 infants originally recruited, 84 aged 4.3 ± 0.5 years completed FOT testing. Median (interquartile range, IQR) for average and peak PM2.5 were 7.9 (6.8–16.8) and 103.4 (60.6–150.7) μg/m3, respectively. The mean ± SD Z‐scores for Rrs5, Xrs5 and AX were 0.56 ± 0.80, –0.76 ± 0.88 and 0.72 ± 0.92, respectively. After adjustment for potential confounders including maternal smoking during pregnancy, a 10 μg/m3 increase in average PM2.5 was significantly associated with worsening AX (β‐coefficient: 0.260; 95% CI: 0.019, 0.502), while the association between a 100‐μg/m3 increase in peak PM2.5 and AX was borderline (0.166; 95% CI: −0.002, 0.334). Conclusion Infant exposure to coal mine fire emissions could be associated with long‐term impairment of lung reactance.

show abstract

Section: Discussionsupporting

confidence: 59%

Early life exposure to coal mine fire smoke emissions and altered lung function in young children

et al. 2019

Self Cite

View full text Add to dashboard Cite

show abstract

“…63 Utilizing the fifth decade follow-up of the Tasmanian Longitudinal Health Study Cohort, Perret et al 64 examined the relationship between maternal smoking and airflow obstruction when subjects were 7 years and again in middle age. The authors reported a 2.7-fold higher association between heavy maternal smoking and spirometrically determined COPD compared with those not exposed.…”

Section: Neil D Evesmentioning

confidence: 99%

“…These findings suggest that early life exposure to smoking predisposes individuals to the development of COPD, especially if they also smoke later in life. 64 …”

Section: Neil D Evesmentioning

confidence: 99%

Year in review 2016: Interstitial lung disease, pulmonary vascular disease, pulmonary function, paediatric lung disease, cystic fibrosis and sleep

et al. 2017

View full text Add to dashboard Cite

“…Prenatal exposure to cigarette smoke is a recognized risk factor for reduced fetal growth and impaired lung function development (reviewed in). Prenatally exposed individuals therefore are at greater risk to develop asthma, both in childhood to adolescence and adulthood, and possibly also chronic obstructive pulmonary disease (COPD) with ageing . Despite decreasing smoking rates in several countries, numbers of women who smoke during pregnancy have remained unacceptably high .…”

Section: Introductionmentioning

confidence: 99%

“…Prenatally exposed individuals therefore are at greater risk to develop asthma, both in childhood 3,4 to adolescence 5 and adulthood, [6][7][8] and possibly also chronic obstructive pulmonary disease (COPD) 9 with ageing. [10][11][12] Despite decreasing smoking rates in several countries, numbers of women who smoke during pregnancy have remained unacceptably high. 13,14 In addition, pregnant women are starting to use e-cigarettes at rapidly increasing rates almost equal to conventional cigarettes.…”

Section: Introductionmentioning

confidence: 99%

In utero exposure to cigarette smoke and effects across generations: A conference of animals on asthma

Hammer

Wagner

Rankov

et al. 2018

Clin Experimental Allergy

Self Cite

View full text Add to dashboard Cite

Summary Background The prevalence of asthma and chronic obstructive pulmonary disease (COPD) has risen markedly over the last decades and is reaching epidemic proportions. However, underlying molecular mechanisms are not fully understood, hampering the urgently needed development of approaches to prevent these diseases. It is well established from epidemiological studies that prenatal exposure to cigarette smoke is one of the main risk factors for aberrant lung function development or reduced fetal growth, but also for the development of asthma and possibly COPD later in life. Of note, recent evidence suggests that the disease risk can be transferred across generations, that is, from grandparents to their grandchildren. While initial studies in mouse models on in utero smoke exposure have provided important mechanistic insights, there are still knowledge gaps that need to be filled. Objective Thus, in this review, we summarize current knowledge on this topic derived from mouse models, while also introducing two other relevant animal models: the fruit fly Drosophila melanogaster and the zebrafish Danio rerio. Methods This review is based on an intensive review of PubMed‐listed transgenerational animal studies from 1902 to 2018 and focuses in detail on selected literature due to space limitations. Results This review gives a comprehensive overview of mechanistic insights obtained in studies with the three species, while highlighting the remaining knowledge gaps. We will further discuss potential (dis)advantages of all three animal models. Conclusion/Clinical Relevance Many studies have already addressed transgenerational inheritance of disease risk in mouse, zebrafish or fly models. We here propose a novel strategy for how these three model organisms can be synergistically combined to achieve a more detailed understanding of in utero cigarette smoke‐induced transgenerational inheritance of disease risk.

show abstract

Mother's smoking and complex lung function of offspring in middle age: A cohort study from childhood

Cited by 34 publications

References 31 publications

Early life exposure to coal mine fire smoke emissions and altered lung function in young children

Early life exposure to coal mine fire smoke emissions and altered lung function in young children

Year in review 2016: Interstitial lung disease, pulmonary vascular disease, pulmonary function, paediatric lung disease, cystic fibrosis and sleep

In utero exposure to cigarette smoke and effects across generations: A conference of animals on asthma

Contact Info

Product

Resources

About