Most Frequent Musculoskeletal Manifestation of Systemic Lupus Erythematosus Patients in Dr. Hasan Sadikin General Hospital Bandung

Abstract

Background: Systemic Lupus Erythematosus (SLE) is an autoimmune disease with wide range of clinical symptoms. The patients frequently complain musculoskeletal involvement during the active state of the disease. Musculoskeletal manifestation in SLE patients is an important sign in making early diagnosis and monitoring treatment response. This study aims to determine the presentation of musculoskeletal involvement of SLE patients in Dr. Hasan Sadikin General Hospital Bandung.Methods: a descriptive cross-sectional quantitative study done by interviewing SLE patients concerning musculoskeletal manifestation as the primary data and tracking their medical record as the secondary data. Study was conducted between September to November 2016 in Rheumatology Clinic Dr. Hasan Sadikin General Hospital Bandung.Result: Ninety-seven SLE patients, 91 females (93,81%) and 6 males (6,19%), were enrolled in this study with mean age 35.12 (±10.91) years. The three highest proportions of muskuloskeltal manifestations were arthritis of the knee (84,5%), myalgia of upper back(40,2%), and muscle weakness (15,5%). We did not find any Jaccoud’s Arthropathy (JA) and tendinitis manifestation. Osteoporosis were occured in 4 patients (4,12%), whereas gout arthritis, spondytlitis, osteoarthritis, rotator cuff syndrome, and rhupus wereonly occured in one patient (1,03%), respectively.Conclusion: The common musculoskeletal manifestation in SLE patients were arthritis of knee, myalgia of upper back, and muscle weakness. Only small portion of patients suffered from osteoporosis, gout arthritis, spondytlitis, osteoarthritis, rotator cuff syndrome, and rhupus.Keyword: musculoskeletal manifestation, musculoskletal involment, SLE

Systematic Lupus Erythematosus (SLE): A review on the prevalence, clinical manifestation, and disease assessment

“…Tenosynovitis is an early symptom of SLE associated with tendon rupture found on patellar tendon, Achilles tendon, the long head of the biceps, the triceps and the extensor tendons of the hands. It has been estimated that the, muscle involvement among SLE patients is up to 30-50% of patients [50] .…”

Oral lesions in adult- and juvenile-onset systemic lupus erythematosus patients: A case series report

“…Lupus erythematosus (LE), commonly referred to as systemic lupus erythematosus (SLE), is an autoimmune disease that can affect multiple organs and present with various clinical manifestations. 1,2 The incidence of SLE has increased in recent years, with reported rates of 2-8 cases per 100,000 individuals in Europe, South America and North America, 51 cases per 100,000 individuals in the USA, 1 and 30-50 cases per 100,000 individuals in Asia, where the incidence varied from 0.9/100,000 to 3.1% per year. The epidemiological data on SLE differs between Asian countries and is difficult to generalize.…”

“…3 In 2010, 291 SLE patients were registered at the Rheumatology Clinic of Dr. Hasan Sadikin Central General Hospital (Bandung, Indonesia), accounting for 10.5% of all patients registered at the Rheumatology Clinic. 1 In 1997, the American College of Rheumatology (ACR) issued a set of diagnostic criteria for SLE, which were revised in 2012 by the Systemic Lupus Erythematosus International Collaborating Clinics (SLICC) to be more sensitive but less specific. 4 These criteria are used to diagnose SLE in children and adults.…”