Most British Surgeons Would Consider Using a Tissue-Engineered Anterior Cruciate Ligament: A Questionnaire Study

Rathbone, Sarah; Maffulli, Nicola; Cartmell, Sarah H.

doi:10.1155/2012/303724

Cited by 25 publications

(12 citation statements)

References 16 publications

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“…Tensile tests were performed on isolated PLCL fibres, at given times after the extrusion process. Prior to the extrusion, raw polymer was stored at À80 C. After the extrusion, polymer fibres were maintained in an incubator at 37 C within distilled water and tested in uniaxial tension at dedicated time points (days 0, 5,8,14,19,26,32,40,49,54,60,67,75). In recent studies, 45,46,48 it has been proposed that hydrolytic degradation may be modelled using a damage variable expressed as…”

Section: Effect Of Hydrolytic Degradation On Mechanical Propertiesmentioning

confidence: 99%

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Suitability of a PLCL fibrous scaffold for soft tissue engineering applications: A combined biological and mechanical characterisation

et al. 2018

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Poly(lactide-co-ε-caprolactone) (PLCL) has been reported to be a good candidate for tissue engineering because of its good biocompatibility. Particularly, a braided PLCL scaffold (PLL/PCL ratio = 85/15) has been recently designed and partially validated for ligament tissue engineering. In the present study, we assessed the in vivo biocompatibility of acellular and cellularised scaffolds in a rat model. We then determined its in vitro biocompatibility using stem cells issued from both bone marrow and Wharton Jelly. From a biological point of view, the scaffold was shown to be suitable for tissue engineering in all these cases. Secondly, while the initial mechanical properties of this scaffold have been previously reported to be adapted to load-bearing applications, we studied the evolution in time of the mechanical properties of PLCL fibres due to hydrolytic degradation. Results for isolated PLCL fibres were extrapolated to the fibrous scaffold using a previously developed numerical model. It was shown that no accumulation of plastic strain was to be expected for a load-bearing application such as anterior cruciate ligament tissue engineering. However, PLCL fibres exhibited a non-expected brittle behaviour after two months. This may involve a potential risk of premature failure of the scaffold, unless tissue growth compensates this change in mechanical properties. This combined study emphasises the need to characterise the properties of biomaterials in a pluridisciplinary approach, since biological and mechanical characterisations led in this case to different conclusions concerning the suitability of this scaffold for load-bearing applications.

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Section: Effect Of Hydrolytic Degradation On Mechanical Propertiesmentioning

confidence: 99%

“…The Chaboche-type elasto-plastic law was fitted to stress-strain curves for each tensile test (n ¼ 4), for time steps equal to 0, 5,8,14,19,26,32,40,49,54,60, 67, 75 days. The results in terms of the evolution of material parameters are illustrated in Figure 6.…”

Section: Effect Of Hydrolytic Degradation On Mechanical Propertiesmentioning

confidence: 99%

Suitability of a PLCL fibrous scaffold for soft tissue engineering applications: A combined biological and mechanical characterisation

et al. 2018

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“…The potential of tissue engineered scaffolds for the reconstruction of ruptured ligament tissue is highlighted by Rathbone et al. [15]. High and variable mechanical properties, good biocompatibility as well as a defined degradation behaviour are required for that approach [16–21].…”

Section: Introductionmentioning

confidence: 99%

Long-term hydrolytic degradation study on polymer-based embroidered scaffolds for ligament tissue engineering

Hahn

Breier

Brünig

et al. 2017

Journal of Industrial Textiles

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Following anterior cruciate ligament injury, a mechanically stable tissue replacement is required for knee stability and to avoid subsequent damages. Tissue engineering of the anterior cruciate ligament demands a biocompatible scaffold with a controllable degradation profile to provide mechanical support for 3 to 6 months. It has been argued that embroidered textile scaffolds made of polylactic acid and poly(lactic-co-ɛ-caprolactone) fibres are a promising approach for the ligament tissue engineering with an adapted functionalization and cell seeding strategy. Therefore, the hydrolytic degradation behaviour of embroidered scaffolds made of polylactic acid and a combination of polylactic acid and poly(lactic-co-ɛ-caprolactone) fibres was investigated under physiological conditions for 168 days. The changes in the mechanical behaviour, the molecular weights as well as the surface structures were analysed. Sufficient mechanical properties comparable to native anterior cruciate ligament tissue could be demonstrated for scaffolds made of polylactic acid fibres after 6 months under hydrolysis. These results clarify the potential of using embroidered scaffolds for ligament tissue engineering.

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“…Overall, most surgeons would be prepared to use this technique if it were an improvement over the current technique. 44 …”

Section: Introductionmentioning

confidence: 99%

The potential role of regenerative medicine in the management of traumatic patients

et al. 2014

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Abstract:Traumatic injury represents the most common cause of death in ages 1 to 44 years and a significant proportion of patients treated in hospital emergency wards each year. Unfortunately, for patients who survive their injuries, survival is not equal to complete recovery. Many traumatic injuries are difficult to treat with conventional therapy and result in permanent disability. In such situations, regenerative medicine has the potential to play an important role in recovery of function. Regenerative medicine is a field that seeks to maintain or restore function with the development of biological substitutes for diseased or damaged tissues. Several regenerative approaches are currently under investigation, with a few achieving clinical application. For example, engineered skin has gained FDA approval, and more than 20 tissue engineered skin substitutes are now commercially available. Other organ systems with promising animal models and small human series include the central and peripheral nervous systems, the musculoskeletal system, the respiratory and genitourinary tracts, and others. This paper will be a clinically oriented review of the regenerative approaches currently under investigation of special interest to those caring for traumatic patients.

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Most British Surgeons Would Consider Using a Tissue-Engineered Anterior Cruciate Ligament: A Questionnaire Study

Cited by 25 publications

References 16 publications

Suitability of a PLCL fibrous scaffold for soft tissue engineering applications: A combined biological and mechanical characterisation

Suitability of a PLCL fibrous scaffold for soft tissue engineering applications: A combined biological and mechanical characterisation

Long-term hydrolytic degradation study on polymer-based embroidered scaffolds for ligament tissue engineering

The potential role of regenerative medicine in the management of traumatic patients

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