MoS₂–Gd Chelate Magnetic Nanomaterials with Core–Shell Structure Used as Contrast Agents in in Vivo Magnetic Resonance Imaging

Abstract

Despite their frequent usages as contrast agents for in vivo MRI imaging, paramagnetic molecules continue to suffer from low resolution, physicochemical instability, and high toxicity. Herein, we present a molybdenum disulfide and gadolinium complex, as an alternative core-shell magnetic nanomaterial that exhibits enhanced paramagnetic property; 4.5-times longer water proton spin-lattice relaxation time (T1) when compared to commercial gadolinium contrast agents; as well as lowered toxicity, extended blood circulation time, increased stability, and desirable excretion characteristic. Transmission electron microscopy (TEM) revealed smooth core-shell nanoparticles 100 nm in size with a shell width of approximately 10 nm. These findings suggest that the synthesized nanomaterial possesses high potential as a positive contrast agent for the enhancement of MRI imaging.

Pluronic F127 self-assembled MoS2 nanocomposites as an effective glutathione responsive anticancer drug delivery system

“…The greater particle size might be due to the negative charge of MoS 2 –GSH which may have allowed a strong electrostatic interaction with the positive group of CYS. 48,49 In contrast, PF127 polymer coating reduced the size of the nanocarrier from size of MoS 2 –GSH–CYS particle from 110.2 nm to 82.3 nm. 50,51 Zeta potential values for MoS 2 –GSH and MoS 2 –GSH–PF127 were −12.2 mV, and −15.7 mV, respectively.…”

“…3c ). 48 MoS 2 –GSH–CYS–PF127 ( Fig. 3d ) had a core shell structure with additional small and larger-sized aggregate particles that resembled the nanocomposites.…”

Dual Functionalization of Liquid‐Exfoliated Semiconducting 2H‐MoS2 with Lanthanide Complexes Bearing Magnetic and Luminescence Properties

“…Hence, we conclude that the 2 H ‐MoS 2 does not undergo a phase change during functionalization as others have reported. [18a,27]…”

“…Graphene has been functionalized with either Gd(III) or Tb(III) complexes, and with Eu 2 O 3 nanoparticles . Recently, MoS 2 was exfoliated using cysteamine, and reacted with DTPA‐dianhydride (DTPA = dielthylenetriaminepentaacetic acid) to form a Gd(III) chelate . However, the MoS 2 nanosheets agglomerated during exfoliation with cysteamine to form large spheres, eventually forming a core–shell‐like structure when reacted with Gd 3+ .…”

Butyl Rubber Nanocomposites with Monolayer MoS2 Additives: Structural Characteristics, Enhanced Mechanical, and Gas Barrier Properties

“…In addition, MoS 2 can be exfoliated into nanolayers without the need for complex methods. MoS 2 nanosheets have previously been utilized in transistors [1], biomaterials [2], and nanocomposites [3], and can also be added to polymers as a filler material; because of the high band gap of MoS 2 , the electronic properties of the polymer matrices are not changed. A common reason to add fillers to polymers is to improve their mechanical properties.…”