Mortality risk of bloodstream infection caused by either Escherichia coli or Klebsiella pneumoniae producing extended-spectrum β-lactamase: a prospective cohort study

Abstract

ObjectiveSeveral studies reported that infection of extended-spectrum β lactamase (ESBL)-producing Escherichia coli (E. coli) or Klebsiella pneumoniae (K. pneumoniae) contributed to higher mortality rates but others found it was not associated with mortality. A prospective cohort study which involved 72 patients was conducted to assess the risk of mortality of bloodstream infection due to ESBL-producing K. pneumoniae or E. coli as compared to those infected by either K. pneumoniae or E. coli which not produce ESBL.ResultMortality in the group of patients infected with ESBL-producing bacteria was 30.6%, whereas in another group which was infected with non ESBL-producing bacteria was 22.2% (p = 0.59). Kaplan–Meier’s analysis showed that the survival rate during 14-days follow-up among these two group was not significantly different (p = 0.45) with hazard ratio 1.41 (95% CI 0.568–3.51). Stratification analysis found that adult and elderly patients, patients with sign of leukocytosis, and patients treated with carbapenem were modifier effect variables.

Antibiotic Susceptibility, Virulome, and Clinical Outcomes in European Infants with Bloodstream Infections Caused by Enterobacterales

“…AMR has been broadly investigated in the adult population, with the majority of studies reporting a significant association between multiple resistance to antibiotics and patients mortality [7,[34][35][36]. Some large cohorts have not found a clear correlation between AMR and adverse outcome [8,12,13]. Data from this small study did not confirm a significant impact of resistance profile on neonatal mortality [5].…”

“…Very few data are available on the impact of different treatment regimens on clinical outcome in neonates with GN-BSIs. Previous studies conducted in both adults and children showed conflicting results on the impact of resistance profiles, appropriateness of empirical treatment and clinical characteristics on patients' mortality [7][8][9][10][11][12][13][14][15]. In the last decade, the implementation of modern bioinformatics to assist next-generation sequencing data analysis greatly improved the knowledge on the genetic characterization of pathogenic strains that may serve as target for new therapies [16].…”

Factores de riesgo para infección asociada a la atención en salud por gérmenes productores de BLEE en una unidad de cuidados intensivos de un Hospital Público de referencia en Bogotá, D.C. Colombia

“…Tabla 1 Análisis bivariado de los factores de riesgo para infección por betalactamasas de espectro extendido (BLEE) producida por K. pneumoniae y E. coli en la Unidad de Cuidado Intensivo del Hospital de Kennedy (10,24,27). Aunque, sí hubo asociación importante de las variables días de estancia en UCI y días de ventilación mecánica, similar a lo que se ha reportado en la literatura (19,20), siendo mayor en el grupo de casos, lo que es importante resaltar dada su asociación causal y como consecuencia de la infección por germen BLEE; sin embargo, dado el diseño del estudio no fue posible caracterizarlas como factor de riesgo solamente, por lo que se excluyó del análisis multivariado por alto riesgo de corresponder a una variable confusora.…”

Pre-treatment neutrophil-lymphocyte and platelet-lymphocyte ratios as additional markers for breast cancer progression: A retrospective cohort study

“…NLR was calculated as a ratio between the absolute count of neutrophils and lymphocytes and PLR was calculated as a ratio between the absolute number of platelets and lymphocytes. Complete blood count analysis was performed in the central clinical pathology lab following the standardized procedures [ 24 ].…”