Mortality risk factors for listeriosis – A 10 year review of non-pregnancy associated cases in England 2006–2015

Scobie, Antonia; Kanagarajah, Sanch; Harris, Ross; Byrne, Lisa; Amar, Corinne; Grant, Kathie; Godbole, Gauri

doi:10.1016/j.jinf.2018.11.007

Cited by 32 publications

(20 citation statements)

References 23 publications

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“…Our study revealed that old age, concurrent steroid usage, and respiratory distress at presentation were associated with 30-day mortality. Our findings were compatible with several large-scale studies from western countries (Charlier et al, 2017;Preussel et al, 2015;Scobie et al, 2019). In addition, patients receiving adjunctive dexamethasone in neurolisteriosis showed a higher mortality (Charlier et al, 2017).…”

Section: Discussionsupporting

confidence: 91%

“…Dietary education should be emphasized in these populations. The distribution of major clinical diagnoses including bacteremia and neurolisteriosis were the same as recent reports, however, certain proportions of our cirrhotic patients suffered from SBP (30.0%), an uncommon presentation of compared with other reports (Charlier et al, 2017;Li et al, 2019;Wang et al, 2013a, b;Preussel et al, 2015;Scobie et al, 2019). Cephalosporins were ineffective against listeriosis and widely used as initial antibiotics for SBP; therefore, caution should be taken when managing cirrhotic patients with poor response to empirical treatment.…”

Section: Discussionsupporting

confidence: 79%

“…Few studies have addressed detailed clinical characteristics of listeriosis from this area (Fan et al, 2019;Li et al, 2019). Our current study showed multiple comorbidities in our patients like in surveillance studies of sporadic listeriosis in western countries (Charlier et al, 2017;Preussel et al, 2015;Scobie et al, 2019). A large proportion (>60%) of our patients had underlying malignancies and were undergoing chemotherapy at disease onset, as reported in our previous study (Huang et al, 2011).…”

Section: Discussionsupporting

confidence: 74%

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Clinical and molecular epidemiology of human listeriosis in Taiwan

Huang

Kuo

Lee

et al. 2021

International Journal of Infectious Diseases

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To determine serogroups, multilocus sequence typing (MLST) of Listeria monocytogenes isolates and analyze clinical characteristics of these clones focusing on non-perinatal cases. Methods: From 2000 to 2015, we analyzed 123 human listeriosis cases at a medical center in northern Taiwan using PCR serogrouping, MLST, and clinical presentations. Results: The annual incidence of listeriosis increased since 2005 with a peak in 2008 (0.2 per 1000 admission) and decreased thereafter. Of the 115 non-perinatal listeriosis cases, we found a male predominance (60%) with an average age of 63.9 years old (standard deviation: 15.3 years), and almost all patients had underlying conditions including malignancies (61.7%), steroid usage (39.1%), diabetes mellitus (31.3%), renal insufficiency (27.8%), and liver cirrhosis (17.4%). Clinical presentations included bacteremia (74.8%), neurolisteriosis (20.0%), and spontaneous bacterial peritonitis (5.2%). The most frequently identified serogroup-sequence types (ST) were IIB-ST87 (30.9%), followed by IIA-ST378 (16.3%) and IIA-ST155 (14.6%). The 30-day all-cause mortality of non-perinatal listeriosis was 25.2% and was associated with age (Hazard ratio: 1.04, 95% C.I. = 1.01-1.07, p = 0.021), steroid usage (Hazard ratio: 2.54, 95% C.I. = 1.06-6.11, p = 0.038) and respiratory distress at presentation (Hazard ratio: 2.59, 95% C.I. = 1.05-6.39, p = 0.038); while no association was found with serogroups (IIA, IIB, and IVB) or three major ST types by multivariable analysis. All 8 mothers of perinatal listeriosis patients survived and three neonates died (mortality, 37.5%), and IIB-ST87 was the major type (62.5%). Conclusion: Predominant strains in Taiwan could cause significant morbidity and mortality. Further disease monitoring and source surveillance are warranted despite a declining trend of human listeriosis in Taiwan.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 79%

Section: Discussionsupporting

confidence: 74%

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Clinical and molecular epidemiology of human listeriosis in Taiwan

Huang

Kuo

Lee

et al. 2021

International Journal of Infectious Diseases

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“…Risk factors for mortality are type 2 diabetes mellitus (DM), old age, steroid use, respiratory distress, solid organ malignancy, and hepatic decompensation [ 11 , 12 , 13 ]. In the western world, risk factors for similar mortality are alcoholism, kidney disease, cardiovascular disease, immunosuppression, septicemia, multi-organ failure, and monocytopenia [ 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Performance of Scoring Systems in Predicting Clinical Outcomes in Patients with Bacteremia of Listeria monocytogenes: A 9-Year Hospital-Based Study

Huang

Hsieh

et al. 2021

Biology

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Background: Listeria monocytogenes (LM) is a facultative anaerobe, Gram-positive bacillus which is widely distributed in nature, and can be separated from soil, water, and rotten vegetables. Immunocompetent people are less likely to suffer from LM infection or may only show gastrointestinal symptoms. However, immunocompromised elderly people, pregnant women, and newborns may develop life-threatening invasive infections. The mortality rate of LM infection is as high as 25–30%. The aim of this study is to investigate clinical scores of patients with bacteremia of LM confirmed by one or more blood cultures. We analyzed their demographics and laboratory findings in relation to their clinical outcomes. Materials and Methods: This was a hospital-based retrospective study on patients with bacteremia of LM. Data were collected from the electronic clinical database of Taichung Veterans General Hospital between January 2012 and December 2020. Bacteremia of LM was confirmed by at least one blood culture. Demographics, clinical characteristics, and laboratory data were collected for analysis. A variety of clinical scoring systems were used to predict the clinical outcome. Results: A total of 39 patients had confirmed bacteremia of LM. Among them, 1 neonatal patient was excluded. The remaining 38 patients were studied. They included 16 males (42.1%) and 22 females (57.9%), with a mean age of 59.9 ± 19.6 years. Their hospital stay averaged 23.3 ± 20.9 days. The in-hospital mortality rate was 36.8%. Mortality in Emergency Department Sepsis (MEDS) Score was 6.6 ± 4.0 for survivors and 12.4 ± 4.4 for non-survivors (P < 0.001). The National Early Warning Score (NEWS) was 3.9 ± 2.8 for survivors and 7.8 ± 3.1 for non-survivors (P = 0.001). Regarding the prediction of mortality risk, the AUC of ROC was 0.829 for MEDS and 0.815 for NEWS. Conclusions: MEDS and NEWS were both good predictors of the clinical outcome in LM bacteremic patients. In those with higher scores of MEDS (≥10) and NEWS (≥8), we recommended an early goal-directed therapy and appropriate antibiotic treatment as early as possible to reduce mortality. Further large-scale studies are required to gain a deeper understanding of this disease and to ensure patient safety.

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“…Dear Editor, Scobie et al recently reported a 10-year review of non-pregnant listeriosis cases in England 1 .…”

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confidence: 99%