Cutaneous listeriosis, a case series of 16 consecutive patients over 25 years

Pilmis, Benoît; Leclercq, Alexandre; Maury, Mylène M.; Moura, Alexandra; Bracq-Dieye, Hélène; Thouvénot, Pierre; Valès, Guillaume; Lecuit, Marc; Charlier, Caroline

doi:10.1016/j.jinf.2019.10.004

Cited by 8 publications

(9 citation statements)

References 9 publications

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“…Moreover, Lm has been sporadically isolated from "pox-like" skin lesions in pigs and from a dog with papulo-pustular dermatitis. 125,178,194,230 Listerial keratoconjunctivitis and uveitis is rather common in ruminants (with a reported farm prevalence of up to 8.6%), 87,88 especially in cattle, as outbreaks or sporadic cases. 87,167,170 Sporadic cases have also been rarely reported in horses.…”

Section: Cutaneous and Ocular Listeriosismentioning

confidence: 99%

Listeria monocytogenes at the interface between ruminants and humans: A comparative pathology and pathogenesis review

2021

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The bacterium Listeria monocytogenes ( Lm) is widely distributed in the environment as a saprophyte, but may turn into a lethal intracellular pathogen upon ingestion. Invasive infections occur in numerous species worldwide, but most commonly in humans and farmed ruminants, and manifest as distinct forms. Of those, neuroinfection is remarkably threatening due to its high mortality. Lm is widely studied not only as a pathogen but also as an essential model for intracellular infections and host-pathogen interactions. Many aspects of its ecology and pathogenesis, however, remain unclear and are rarely addressed in its natural hosts. This review highlights the heterogeneity and adaptability of Lm by summarizing its association with the environment, farm animals, and disease. It also provides current knowledge on key features of the pathology and (molecular) pathogenesis of various listeriosis forms in naturally susceptible species with a special focus on ruminants and on the neuroinvasive form of the disease. Moreover, knowledge gaps on pathomechanisms of listerial infections and relevant unexplored topics in Lm pathogenesis research are highlighted.

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Section: Cutaneous and Ocular Listeriosismentioning

confidence: 99%

Listeria monocytogenes at the interface between ruminants and humans: A comparative pathology and pathogenesis review

2021

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“…Listeria monocytogenes is the genetically heterogeneous species (Kathariou, 2002) implicated in numerous outbreaks of invasive listeriosis reported globally, characterized by septicemia, meningoencephalitis, and maternal-fetal infection leading to abortion (Shoai-Tehrani et al, 2019;Pilmis et al, 2020). The acquisition of this disease is mainly due to the consumption of contaminated food (Lomonaco et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Genomic Determinants of Pathogenicity and Antimicrobial Resistance for 60 Global Listeria monocytogenes Isolates Responsible for Invasive Infections

Shi

Anwar

Pan

et al. 2021

Front. Cell. Infect. Microbiol.

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Listeria monocytogenes remains a significant public health threat, causing invasive listeriosis manifested as septicemia, meningitis, and abortion, with up to 30% of cases having a fatal outcome. Tracking the spread of invasive listeriosis requires an updated knowledge for virulence factors (VFs) and antimicrobial resistance features, which is an essential step toward its clinical diagnosis and treatment. Taking advantage of high-throughput genomic sequencing, we proposed that the differential genes based on the pathogenomic composition could be used to evaluate clinical observations and therapeutic options for listeriosis. Here, we performed the comparative genomic analysis of 60 strains from five continents with a diverse range of sources, representing serotypes 1/2a, 1/2b, 1/2c, and 4b, comprising lineage I and lineage II and including 13 newly contributed Chinese isolates from clinical cases. These strains were associated with globally distributed clonal groups linked with confirmed foodborne listeriosis outbreak and sporadic cases. We found that L. monocytogenes strains from clonal complex (CC) CC8, CC7, CC9, and CC415 carried most of the adherence and invasive genes. Conversely, CC1, CC2, CC4, and CC6 have the least number of adherence and invasive genes. Additionally, Listeria pathogenicity island-1 (LIPI-1), LIPI-2, intracellular survival, surface anchoring, and bile salt resistance genes were detected in all isolates. Importantly, LIPI-3 genes were harbored in CC3, CC224, and ST619 of the Chinese isolates and in CC1, CC4, and CC6 of other worldwide isolates. Notably, Chinese isolates belonging to CC14 carried antibiotic resistance genes (ARGs) against β-lactams (blaTEM-101, blaTEM-105) and macrolide (ermC-15), whereas CC7 and CC8 isolates harbored ARGs against aminoglycoside (aadA10_2, aadA6_1), which may pose a threat to therapeutic efficacy. Phylogenomic analysis showed that CC8, CC7, and CC5 of Chinese isolates, CC8 (Swiss and Italian isolates), and CC5 and CC7 (Canadian isolates) are closely clustered together and belonged to the same CC. Additionally, CC381 and CC29 of Chinese isolates shared the same genomic pattern as CC26 of Swiss isolate and CC37 of Canadian isolate, respectively, indicating strong phylogenomic relation between these isolates. Collectively, this study highlights considerable clonal diversity with well-recognized virulence and antimicrobial-resistant determinants among Chinese and worldwide isolates that stress to design improved strategies for clinical therapies.

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“…Human listeriosis manifests as septicemia, central nervous system and maternal-fetal infections, as well as rare forms of localised infections (Charlier et al, 2012;Charlier et al, 2014;Chersich et al, 2018;Danion et al, 2017;Morgand et al, 2018;Pilmis et al, 2019;Shoai-Tehrani et al, 2019). Upon ingestion of a large inoculum, Lm also induces a benign and spontaneously resolutive gastroenteritis in immunocompetent individuals (Aureli et al, 2000;Dalton et al, 1997).…”

Section: Listeria Monocytogenes and Listeriosismentioning

confidence: 99%

Listeria monocytogenes, a model in infection biology

Lecuit

2020

Cellular Microbiology

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Listeria monocytogenes causes listeriosis, a systemic infection which manifests as bacteremia, often complicated by meningoencephalitis in immunocompromised individuals and the elderly, and fetal‐placental infection in pregnant women. It has emerged over the past decades as a major foodborne pathogen, responsible for numerous outbreaks in Western countries, and more recently in Africa. L. monocytogenes' pathogenic properties have been studied in detail, thanks to concomitant advances in biological sciences, in particular molecular biology, cell biology and immunology. L. monocytogenes has also been instrumental to basic advances in life sciences. L. monocytogenes therefore stands both a tool to understand biology and a model in infection biology. This review briefly summarises the clinical and some of the pathophysiological features of listeriosis. In the context of this special issue, it highlights some of the major discoveries made by Pascale Cossart in the fields of molecular and cellular microbiology since the mid‐eighties regarding the identification and characterisation of multiple bacterial and host factors critical to L. monocytogenes pathogenicity. It also briefly summarises some of the key findings from our laboratory on this topic over the past years.

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Cutaneous listeriosis, a case series of 16 consecutive patients over 25 years

Cited by 8 publications

References 9 publications

Listeria monocytogenes at the interface between ruminants and humans: A comparative pathology and pathogenesis review

Listeria monocytogenes at the interface between ruminants and humans: A comparative pathology and pathogenesis review

Genomic Determinants of Pathogenicity and Antimicrobial Resistance for 60 Global Listeria monocytogenes Isolates Responsible for Invasive Infections

Listeria monocytogenes, a model in infection biology

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