Mortality response of folate receptor-activated, PEG–functionalized TiO2 nanoparticles for doxorubicin loading with and without ultraviolet irradiation

Naghibi, Sanaz; Hosseini, H.R. Madaah; Sani, Mohammad Ali Faghihi; Shokrgozar, Mohammad Ali; Mehrjoo, Morteza

doi:10.1016/j.ceramint.2013.10.136

Cited by 35 publications

(29 citation statements)

References 28 publications

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“…Fig 3A shows vibration [19,20] and at 846 cm −1 which has been attributed to the formation of cubic 144 phase of MgO [19]. The FTIR PEG shows the characteristic bands at 2929 cm −1 , 2888 145 cm −1 , 1342 cm −1 , 1242 cm −1 and 1100 cm −1 that have been described by [21,22].…”

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confidence: 92%

MgO nanoparticles coated with Polyethylene Glycol as carrier for 2-Methoxyestradiol anticancer drug

Alfaro

León

Guajardo

et al. 2019

Preprint

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Novel Magnesium Oxide (MgO) nanoparticles (NPs) modified with the polymer poliethylene glycol (PEG) were synthesized as carrier for the anticancer drug 2-Methoxyestradiol (2ME) to improve its clinical application. The functionalized NPs were characterized by Infrared spectroscopy with Fourier transform to elucidate the vibration modes of this conjugate, indicating the formation of the MgO-PEG-2ME nanocomposite. The studies of absorption and liberation determined that MgO-PEG-2ME NPs incorporated 98.51 % of 2ME while liberation of 2ME was constant during 7 days at pH 2, 5 and 7.35. Finally, the MgO-PEG-2ME NPs decreased the viability of the prostate cancer cell line LNCap suggesting that this nanocomposite is suitable as a drug delivery system for anticancer prostate therapy. 12March 15, 2019 1/9 2-Metoxyestradiol (2ME) has antitumor activity in several types of cancer of the 13 reproductive tract as prostate, cervix, ovary or endometrium. 2ME exerts its anticancer 14 activity via anti-proliferative, apoptotic or antiangiogenic effects on tumor cells [7]. 15 Despite to be considerate as a promising anticancer drug it has an unfavorable kinetic 16 with a low solubility in water; Thus, it is necessary to find new ways to facilitate its 17 administration to the human body. In this context, the nanoparticles (NPs) as drug 18 carriers can play a fundamental role to improvement biological parameters. Actually, it 19 has been proposed that polymeric NPs [8] or TiO 2 NPs coated with polyethylene glycol 20 (PEG) could be useful tools to load 2ME [9]. In the searching for new NPs suitable for 21 medical use, MgO NPs are also an excellent candidate because they are bio-friendly [10]. 22 It has been shown that MgO NPs are not toxic for a variety of human cell lines at 23 concentrations under 300 µg/ml [10]. MgO NPs has been also used as a carrier for the 24 antincancer drug doxorubicin indicating its utility for a controlled system of drugs 25 delivery [11, 12]. In this work, we first performed the physicochemical characterization 26 of MgO NPs coated with PEG and loaded with 2ME (MgO-PEG-2ME). The efficiency 27 of absortion and liberation of 2ME was then analyzed. Finally, the effect of 28 MgO-PEG-2ME NPs on the prostate cell line LnCap was assessed. 29 Materials and Methods 30 Synthesis MgO nanoparticles 31 The MgO NPs were obtained by the sol-gel method route assisted with cetyltrimethyl 32 ammonium bromide C 19 H 4 2BrN (CTAB) as a surfactant to reduce the agglomeration of 33 the NPs [13]. 1:1 molar solution of magnesium acetate, Mg(CH 3 COO) 2 4H 2 O (99,5 %, 34 MERK, USA) and tartaric acid C 4 H 6 O 6 to (99,5 %, MERK, USA) was prepared in 35 ethanol and added dropwise over 10 ml of a 0.001 M of CTAB in water at 60 • C. The 36solution was stirred vigorously for 20 hours to achieve gel formation. Once the gel is 37 formed, it was dried and before calcined at 600 • C for 6 hours to give MgO [14]. 38MgO nanoparticles functionalized with PEG and 2ME loading. 39MgO NPs were covered with poliethylene glycol 600 (PEG600; Sigma...

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confidence: 92%

MgO nanoparticles coated with Polyethylene Glycol as carrier for 2-Methoxyestradiol anticancer drug

Alfaro

León

Guajardo

et al. 2019

Preprint

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“…The photocatalytic behaviors of the synthesized sample as well as TiO 2 -P25 were investigated via measuring the degradation of methylene blue as described previously [19]. For this reason, 100 mg of the powder samples were added to the methylene blue solution (30 mg/L), continuously stirred.…”

Section: Methodsmentioning

confidence: 99%

Perforated ZnO nanoflakes as a new feature of ZnO achieved by the hydrothermal-assisted sol–gel technique

Khaghanpour

Naghibi

2017

J Nanostruct Chem

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The perforated ZnO nanoflakes with high degree of crystallinity and uniformity were synthesized via the hydrothermal-assisted sol-gel technique without any template. ZnCl 2 was used as a Zn-containing precursor, causing the oriented growth of particles. The observation of a hole on the facet of the as-synthesized particles was discussed in this work. XRD, TEM, and DRS were used to investigate the prepared powder and a simple mechanism was suggested to explain the hole formation on the surface of nanoflakes. As a result, the synthesized powder included pure ZnO with direct band gap energy of 3.24 eV. The range of particle size was within 1 lm in diameter and \50 nm in thickness. A circle hole with 300-500 nm in diameter was observed on the facet of the as-synthesized particles.

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“…Its formula is C 63 H 88 CoN 14 O 14 P in which the cobalt ions are not interchangeable with other metals. 1 There are some reports about using VB 12 in biosystems, [2][3] and also its application to modify ceramic and metallic particles.…”

Section: Introductionmentioning

confidence: 99%

“…6 Sensitization of TiO 2 NPs and Fe-TiO 2 NPs by addition of VB 12 solution was reported by Gharagozlou et al [7][8] Also Shimakoshi et al immobilized VB 12 on TiO 2 particles. 9 As a semiconductor ceramic, TiO 2 has unique optical, 10 chemical and biochemical 11 properties that render it an efficient material for several applications, including biomedical science, [12][13][14] anticorrosion thin films, 15 water treatment 16 and solar cells. 17 Some characteristics of TiO 2 vary by modifying its nanoparticles and researchers have tried to enhance this material for photochemical, biological, environmental and medical applications.…”

Section: Introductionmentioning

confidence: 99%

“…Naghibi et al improved TiO 2 NPs colloidal stability in a water base medium by using dextran 18 and poly ethylene glycol (PEG) and also they conjugated folic acid to TiO 2 NPs creating smart targeting ability. 14 Several research teams tried to shift the adsorption edge of TiO 2 NPs via metal ion doping process. [19][20][21][22] Woolerton et al succeeded to photoreduce CO 2 via modification of TiO 2 NPs with carbon monoxide dehydrogenase and a Ru photosensitizer.…”

Section: Introductionmentioning

confidence: 99%

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Surface Modification of TiO₂ Nanoparticles with Vitamin B₁₂: Relationships between Vitamin B₁₂ Content and Its Optical Properties

Gharagozlou

Naghibi

2015

J Chinese Chemical Soc

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Anatase TiO 2 nanoparticles (NPs) with particle size of 10-20 nm were prepared via sol gel technique. The as-synthesized NPs were immerged in vitamin B 12 (VB 12 ) solutions with different concentrations. The influences of the solution concentration on photoluminescence and photocatalytic activity of the modified NPs were studied. Fourier transform infrared spectroscopy (FTIR) results demonstrated that TiO 2 NPs adsorb VB 12 molecules and that a new band is formed at~2300 cm -1 . The VB 12 loading process led to diminishing of the aggregation of NPs and formation of a fibre shape structure. The best photoactivity and PL effect among the modified samples was related to sample 'd'. The optimum processing conditions to achieve this sample was found to be VB 12 concentration of 5 g/L.

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Mortality response of folate receptor-activated, PEG–functionalized TiO2 nanoparticles for doxorubicin loading with and without ultraviolet irradiation

Cited by 35 publications

References 28 publications

MgO nanoparticles coated with Polyethylene Glycol as carrier for 2-Methoxyestradiol anticancer drug

MgO nanoparticles coated with Polyethylene Glycol as carrier for 2-Methoxyestradiol anticancer drug

Perforated ZnO nanoflakes as a new feature of ZnO achieved by the hydrothermal-assisted sol–gel technique

Surface Modification of TiO₂ Nanoparticles with Vitamin B₁₂: Relationships between Vitamin B₁₂ Content and Its Optical Properties

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Mortality response of folate receptor-activated, PEG–functionalized TiO2 nanoparticles for doxorubicin loading with and without ultraviolet irradiation

Cited by 35 publications

References 28 publications

MgO nanoparticles coated with Polyethylene Glycol as carrier for 2-Methoxyestradiol anticancer drug

MgO nanoparticles coated with Polyethylene Glycol as carrier for 2-Methoxyestradiol anticancer drug

Perforated ZnO nanoflakes as a new feature of ZnO achieved by the hydrothermal-assisted sol–gel technique

Surface Modification of TiO2 Nanoparticles with Vitamin B12: Relationships between Vitamin B12 Content and Its Optical Properties

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Surface Modification of TiO₂ Nanoparticles with Vitamin B₁₂: Relationships between Vitamin B₁₂ Content and Its Optical Properties