Mortality of styrene production, polymerization and processing workers at a site in northwest England.

Hodgson, John; Jones, Robert

doi:10.5271/sjweh.2214

Cited by 59 publications

(57 citation statements)

References 6 publications

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“…Nevertheless our results support the concept that occupational exposure to organic solvents may be hazardous with regard to non-Hodgkin's lymphoma. Because such exposure may also be relevant for the development of other malignant disorders of hematopoietic and lymphatic tissue (I, 2,5,7,8,9,IS,16,23,25), our data support the opinion that occupational exposure to organic solvents should be minimized.…”

Section: Discussionsupporting

confidence: 76%

Risk of non-Hodgkin's lymphoma among men occupationally exposed to organic solvents.

Olsson¹,

Brandt²

1988

Scand J Work Environ Health

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OLSSONH, BRANDTL. Risk of non-Hodgkin's lymphomaamong men occupationallyexposedto organic solvents. Scand J Work Environ Health 14(1988) 246-251. An occupational history of exposure to organicsolvents,definedas dailyoccupational exposure for at least one year, wasmore commonamong 167 men with newly diagnosed non-Hodgkin's lymphoma than among 130 healthyreferents from the general population (38 versus 14 070). Categorization in five-year age groups gave 3.3 as a Mantel-Haenszel estimate of the odds ratio (95 070 CI 1.9-5.8). The odds ratio was 6.5 (95 070 CI 3.2-13.3) for localized supradiaphragmatic tumors and 2.3 (95 070 CI 1.3-4.3) for other lymphoma presentations. In a logistic model including age and organic solvent, phenoxy acid, and chlorophenol exposure, it could be shown that solventexposurewasan independent risk factor and that no important interaction occurred between the risk factors. With increasing duration of exposure there wasa significantly increased risk of lymphoma, a finding implying a dose-response relationship. There was no significant difference in tumor histology between the exposed and unexposed patients. These findings support the concept that occupational exposure to organic solvents is a risk factor for non-Hodgkin's lymphoma. The resultsalso confirm a strong association between such exposure and an initial supradiaphragmatic location of the lymphomas.

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Section: Discussionsupporting

confidence: 76%

Risk of non-Hodgkin's lymphoma among men occupationally exposed to organic solvents.

Olsson¹,

Brandt²

1988

Scand J Work Environ Health

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show abstract

“…but different, industries are important to consider. Table 8 summarizes seven published mortality studies (7)(8)(9)(10)(11)(12)(13) of workers who were potentially exposed to styrene-based products in the three general industry classifications of styrene-butadiene rubber, styrene monomer and polymerization, and reinforced plastics. It is critical to differentiate the exposure circumstances in each of these industrie s before consider ing their individual or collective results.…”

Section: Discussionmentioning

confidence: 99%

“…Interpretation of the two studies of workers in general styrene monomer production and polymerization operations (9,10) is similarly hampered by the small number of observed and expected deaths. Hodgson & Jones (9) reported statistically significant excess lymphatic and hematopoietic cancer mortality among workers producing styrene monomer and polymers (3 observed, SMR 536, 95070 CI 110-1565).…”

mentioning

confidence: 99%

Mortality among workers engaged in the development or manufacture of styrene-based products--an update.

Bond¹,

Bodner²,

Olsen³

et al. 1992

Scand J Work Environ Health

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BOND GG, BODNER KM, OLSEN GW, COOK RR. Mortalit y among wor kers engaged in the development or manufactu re of styrene-based produ cts -an update . Scand J Work Environ Health 1992; 18:145-54. Mortality was updated another 11 years through 1986 for a pr eviously studied cohort of 2904 male chemical workers who were potent ially exposed to styrene and related materials for a year or more between 1937 and 1971. Substantial deficits in mortality from all causes and total cancer were observed in the cohort when it was compared with white males in the United States, and also other chemical worker s who were unexposed to styrene-based products. Mortality from leukemia was slightly less than expected during the updated period , in contrast to an excess of lymphatic leukemia observed in the original period. Yet small elevations in risk of other types of lymphatic cancer, particularly multiple myeloma, persisted. The risk of these cancers did not increase with estimated inten sity or duration of styrene exposure. The findings are discussed in context with those of studies of similarly exposed workers in related industries.

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“…[218][219][220][221][222][223][224] Sathiakumar et al 220 reported no association with NHL mortality among styrene-butadiene rubber workers employed in the North-American synthetic rubber industry (SMR 5 1.00, 95% CI: 0.75-1.30). Among rubber industry workers at the same plants, Graff et al 225 reported nonsignificant positive associations with the 4 highest categories of styrene exposure, and nonsignificant inverse associations with the 3 highest categories of butadiene exposure.…”

Section: Occupational and Environmental Chemical Exposurementioning

confidence: 99%

The non-Hodgkin lymphomas: A review of the epidemiologic literature

et al. 2007

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Mortality of styrene production, polymerization and processing workers at a site in northwest England.

Cited by 59 publications

References 6 publications

Risk of non-Hodgkin's lymphoma among men occupationally exposed to organic solvents.

Risk of non-Hodgkin's lymphoma among men occupationally exposed to organic solvents.

Mortality among workers engaged in the development or manufacture of styrene-based products--an update.

The non-Hodgkin lymphomas: A review of the epidemiologic literature

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