Mortality of central nervous system infection adult patients in indonesia (Descriptive study in a tertier referral hospital)

Munir, Badrul; Rianawati, Sri Budhi; Sutanto, Hery; Setyawan, Ungky Agus

doi:10.1016/j.jns.2017.08.3383

Cited by 2 publications

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“…Cerebral tuberculoma is one of the rare extrapulmonary tuberculosis infection that needs serious concern, due to hematogenous spread [1,2]. Positive-smear TB patients is the main source of transmission.…”

Section: Introductionmentioning

confidence: 99%

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Cerebral Tuberculoma without Clinical Pulmonary Tuberculosis Mimicry as Cerebral Abscess: (A Rare Case Report)

Munir

Rianawati

et al. 2019

AJBSR

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Section: Introductionmentioning

confidence: 99%

“…Positive-smear TB patients is the main source of transmission. When a TB patient coughs or sneeze, the bacteria will spread to the air in the form of sputum droplets (droplet nuclei) [2,3]. Cerebral tuberculoma is approximately 10-15% of intracranial tuberculosis cases and 1% of all Mycobacterium tuberculosis (MTB) cases [4,5].…”

Section: Introductionmentioning

confidence: 99%

Cerebral Tuberculoma without Clinical Pulmonary Tuberculosis Mimicry as Cerebral Abscess: (A Rare Case Report)

Munir

Rianawati

et al. 2019

AJBSR

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The Ag38-rec Mycobacterium tuberculosis Antigen as a New Candidate Marker for The Diagnostic of Tuberculosis Meningitis: In Silico Approach

Munir,

Nur Hidayati,

A Nazwar

et al. 2023

RJPT

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Tuberculous meningitis (TBM) is the most severe extrapulmonary infection caused by Mycobacterium tuberculosis (Mtb). An accurate diagnosis of TBM has yet to be established. Periplasmic Phosphate Binding Lipoprotein is a seropositive marker for TBM diagnosis. In the previous study, we tested antigen Ag38 recombinant from local strain and showed potential as a serodiagnosis agent candidate. This study aimed to analyze the variability gene of PstS1 and Ag38 rec and to identify the immune-dominant epitope protein PstS1 and 38recp. The PstS1 gene sequence of Mtb from the Mycobrowser database and 38kDa rec was obtained from the previous study. Variability gene of PstS1 and Ag38 rec was identified through the alignment of both genes. To predict the signal peptide in the PstS1 protein sequence, TargetP -2.0 was used. The candidate epitope on the mature protein was predicted with Bepipred 2.0 on the IEDB server. The results of Bepipred 2.0 were then compared with the Emini Surface Accessibility tool, Karplus and Schulz Flexibility tool, and Parker Hydrophilicity tool. The epitope obtained was further analyzed for antigenicity prediction. The position of the epitope on the 3D structure of the PstS1 protein was modeled with the help of the Ellipro predictor. The alignment result of gene PstS1 with Ag38reg contains an anonymous N base, but there were no mutations. Based on Target-P 2, it was found that the PstS1 protein contains a signal peptide with a truncation site at residues 24 and 25. From the results of the epitope prediction, ten candidate epitopes were obtained. Based on the antigenicity analysis, candidate epitopes were finally obtained. Of the five epitopes, two epitopes were similar to PstS1 Mtb protein crystallization results. Two epitopes are AGFASKTPANQAISMID-GPAPD and QGTIKTWDDPQIAALNPGVNLP. Thus, two potential epitope candidates are diagnostic biomarkers, namely AGFASKTPANQAISMIDGPAPD and QGTIKTWDDPQIAALNPGVNLP. However, further research is needed to validate these epitopes using the tool diagnosis TBM.

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Mortality of central nervous system infection adult patients in indonesia (Descriptive study in a tertier referral hospital)

Cited by 2 publications

References 0 publications

Cerebral Tuberculoma without Clinical Pulmonary Tuberculosis Mimicry as Cerebral Abscess: (A Rare Case Report)

Cerebral Tuberculoma without Clinical Pulmonary Tuberculosis Mimicry as Cerebral Abscess: (A Rare Case Report)

The Ag38-rec Mycobacterium tuberculosis Antigen as a New Candidate Marker for The Diagnostic of Tuberculosis Meningitis: In Silico Approach

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