Mortality in Patients With Septic Shock Correlates With Anti-Inflammatory But not Proinflammatory Immunomodulatory Molecules

Pablo, Raúl de; Monserrat, Jorge; Reyes, Eduardo; Díaz-Martín, David; Zapata, Manuel Rodríguez; Carballo, Fernando; Hera, Alberto De La; Prieto, Alfredo; Álvarez‐Mon, Melchor

doi:10.1177/0885066610384465

Cited by 52 publications

(46 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…12 In several trials, higher IL-10 and IL-4 (antiinflammatory cytokines) levels are reported in patients who died from sepsis, in comparison to surviving patients. 2,8,11,12 In our trial, relation between prognosis and gender, growth in blood culture, Gram-positivity or negativity of growing pathogen, cytokines (TNF-α, IL-10, leptin) and CRP levels in sepsis patients was investigated. In prognosis of pa- tients with sepsis, no relation was determined between prognosis and gender, growth rate in blood culture and Gram-positive or negative of growing pathogen.…”

Section: Discussionmentioning

confidence: 99%

“…Gram positive bacteria which grew in blood cultures (n=6) are methicillin resistant Staphylococcus aureus (MRSA, n=3), methicillin sensitive Staphylococcus aureus (MSSA, n=1), coagulase negative staphylococcus (CNS, n=1), enterococcus species (n=1), respectively. Gram-negative bacteria which grew in blood cultures (n=5) were E.coli (2), Pseudomonas aeruginosa (2), Enterobacter species (spp.) [1] and Acinetobacter spp.…”

Section: J Microbiol Infect Dis Wwwjcmidorg Vol 1 No 3 December 2011mentioning

confidence: 99%

See 1 more Smart Citation

Prognostic value of cytokines (TNF-α, IL-10, Leptin) and C-reactive protein serum levels in adult patients with nosocomial sepsis

Cesur¹

2011

JMID

View full text Add to dashboard Cite

Objectives: The purpose of this trial was to investigate in patients with sepsis, the correlation between prognosis of disease and factors, which influence prognosis like gender, focus of infection, bacterial growth in blood culture, growing pathogens in addition to serum levels of cytokines (TNF-α, IL-10, leptin) and C-reactive protein. Material and methods:Forty-six adult patients with sepsis and 55 healthy adults as control group were enrolled in this study. Serum cytokine (TNF-α, IL-10 and leptin) levels were determined by ELISA method and C-reactive protein (CRP) levels were measured by nephelometric method. Serum cytokine and CRP levels on day 0 (initial), day 3 and day 5 were compared in surviving sepsis patients and patients who died because of sepsis.Results: Serum IL-10 level on day 0 (initial) of adult patients who died as a result of sepsis was found to be higher than surviving patients and the difference was statistically significant (p=0.025). On 3 rd day of treatment, serum TNF-α and CRP levels of patients who dies because of sepsis were higher than values of surviving patients (for TNF-α p=0.033, for CRP p=0.026). In adult patient group with sepsis who died on the 5 th day of treatment, serum TNF-α level was significantly higher than levels in surviving patients (p=0.030). Conclusion:It was determined that in patients who died due to sepsis, initial serum IL-10 level, TNF-α and CRP levels on 3 rd day of treatment and finally on 5 th day of treatment, only serum TNF-α level was higher than surviving patients. We believe that determining serum TNF-α and IL-10 levels in patients with sepsis before and during treatment will help clinicians to clarify prognosis and enable them to implement appropriate treatment modifications. Gereç ve yöntem:Çalışmaya 46 erişkin sepsisli hasta ile kontrol grubu olarak ise 55 sağlıklı erişkin dahil edildi. Serum sitokin (TNF-α, IL-10 ve leptin) düzeyleri ELISA yöntemiyle, C-reaktif protein (CRP) düzeyleri ise nefelometrik yöntemle saptandı.Serum sitokin ve CRP düzeyi sepsili ölen hasta grubu ile yaşayanlar arasında başlangıç (0.gün), 3. ve 5.günlerde istatistiksel olarak karşılaştırıldı.Bulgular: Sepsisten ölen erişkin hastalarda başlangıç (0. gün) serum IL-10 düzeyi, yaşayan hastalarinkinden istatistiksel olarak daha yüksek saptandı (p=0.025). Sepsisten ölen hastalarda, tedavinin 3. gününde serum TNF-α ve CRP düzeyleri yaşayan hastalardan daha yüksekti (TNF-α için p değeri=0.033, CRP için p=0.026). Sepsili erişkin hasta grubunda tedavinin 5. gününde ölen hastalarda serum TNF-α düzeyi yaşayan hastalardan daha yüksekti (p=0.03) Sonuç: Sepsisli erişkin hastalrda tedavi başlangıcında serum IL-10 düzeyinin, tedavinin 3. gününde TNF-α ve CRP dü-zeyinin, tedavininin 5. gününde ise sadece serum TNF-α düzeyinin prognostik olduğu belirlendi. Sepsisli hastalarda serum TNF-α ve IL-10 düzeylerinin tedavinin başlangıcında ve tedavi esnasında saptanması hastaların prognozunun belirlenmesinde ve uygun tedavi değişikliklerinin yapılmasında klinisyene yol gösterici olabilir.An...

show abstract

Section: Discussionmentioning

confidence: 99%

Section: J Microbiol Infect Dis Wwwjcmidorg Vol 1 No 3 December 2011mentioning

confidence: 99%

Prognostic value of cytokines (TNF-α, IL-10, Leptin) and C-reactive protein serum levels in adult patients with nosocomial sepsis

Cesur¹

2011

JMID

View full text Add to dashboard Cite

show abstract

“…Following an exacerbated inflammatory response, usually with elevated production of pro-inflammatory cytokines, septic shock ensues. In an attempt to maintain organic homeostasis in sepsis, there is an increase of the anti-inflammatory mediators [32]. It is currently proposed that the anti-inflammatory cytokines are promptly produced in counterbalance to the onset of an exacerbated systemic immune response [25].…”

Section: Anti-inflammatory Cytokines In the Context Of Sepsismentioning

confidence: 99%

“…Among the deceased, significant quantities of TNF and IL-1 antagonist anti-inflammatory cytokines were found, such as IL-1RA [32]. responsible for altering its activity, initially anti-inflammatory, to proinflammatory activity [33].…”

Section: Anti-inflammatory Cytokines In the Context Of Sepsismentioning

confidence: 99%

Anti-Inflammatory Cytokines in Sepsis: Immunological Studies and In Silico Investigation

AP¹,

DLS²,

PSB³

et al. 2016

J Pharma Care Health Sys

View full text Add to dashboard Cite

The pathophysiology, diagnosis, treatment and prognosis of sepsis remain major challenges for contemporary clinical practice. In this sense, efforts to broaden the knowledge about the mechanisms involved in systemic inflammation and to identify new methods for detecting sepsis in the early stages and the stratification of patients are extremely important. The purpose of this paper is to review the role of the anti-inflammatory cytokines in sepsis and present perspectives on the in silico investigation of the role of these mediators in this nosological entity, using the computational system AutoSimmune.

show abstract

“…While our understanding of the systemic consequences of severe injury and sepsis remains incomplete, as evidenced by the lack of success in translational and clinical trials of therapies aimed at modulating the inflammatory response (5,6), the development of prognosticators based on immunological measures are plentiful (7)(8)(9)(10)(11)(12). Unfortunately, these diagnostics and prognostics have not proved sufficiently successful to enter the clinical armamentarium.…”

Section: Introductionmentioning

confidence: 99%

Development of a Genomic Metric that can be Rapidly Used to Predict Clinical Outcome in Severely Injured Trauma Patients

Gentile

Cuenca

López

et al. 2013

Journal of Surgical Research

View full text Add to dashboard Cite

Objective-Many patients following severe trauma have complicated recoveries due to the development of organ injury. Physiological and anatomical prognosticators have had limited success in predicting clinical trajectories. We report on the development and retrospective validation of a simple genomic composite score that can be rapidly used to predict clinical outcomes. Design-Retrospective cohort study Setting-Multi-institution level 1 trauma centers Patients-Data was collected from 167 severely traumatized (ISS >15) adult (18-55 yo) patientsMethods-Microarray-derived genomic data obtained from 167 severely traumatized patients over 28 days were assessed for differences in mRNA abundance between individuals with different clinical trajectories. Once a set of genes was identified based on differences in expression over the entire study period, mRNA abundance from these subjects obtained in the first 24 hours was analyzed in a blinded fashion using a rapid multiplex platform, and genomic data reduced to a single metric.Results-From the existing genomic data set, we identified 63 genes whose leukocyte expression differed between an uncomplicated and complicated clinical outcome over 28 days.

show abstract

Mortality in Patients With Septic Shock Correlates With Anti-Inflammatory But not Proinflammatory Immunomodulatory Molecules

Cited by 52 publications

References 33 publications

Prognostic value of cytokines (TNF-α, IL-10, Leptin) and C-reactive protein serum levels in adult patients with nosocomial sepsis

Prognostic value of cytokines (TNF-α, IL-10, Leptin) and C-reactive protein serum levels in adult patients with nosocomial sepsis

Anti-Inflammatory Cytokines in Sepsis: Immunological Studies and In Silico Investigation

Development of a Genomic Metric that can be Rapidly Used to Predict Clinical Outcome in Severely Injured Trauma Patients

Contact Info

Product

Resources

About