Prognostic value of cytokines (TNF-α, IL-10, Leptin) and C-reactive protein serum levels in adult patients with nosocomial sepsis

Cesur, Salih

doi:10.5799/ahinjs.02.2011.03.0024

Cited by 7 publications

(4 citation statements)

References 18 publications

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“…Interleukin-10 (IL-10), released by Th2 subgroup lymphocytes mediates the immune response by neutralising the proinflammatory action of IL-1 and TNF, having a subsequent protective effect on lipopolysaccharide-induced pathogeny. Elevated plasma levels indicate the presence of severe inflammation and correlation with severity and mortality in sepsis has been reported [ 41 ]. Recently, an increase in sepsis susceptibility and morbidity has been suggested by the presence of a promoter SNP for the -1082 polymorphism [ 34 , 41 , 42 , 43 , 44 ], although two meta-analyses confirmed the association only in an Asian population [ 45 , 46 ].…”

Section: Cytokinesmentioning

confidence: 99%

The Relevance of Coding Gene Polymorphysms of Cytokines and Cellular Receptors in Sepsis

Georgescu

Grigorescu

Chirteș

et al. 2017

The Journal of Critical Care Medicine

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Sepsis is an injurious systemic host response to infection, which can often lead to septic shock and death. Recently, the immune-pathogenesis and genomics of sepsis have become a research topic focusing on the establishment of diagnostic and prognostic biomarkers. As yet, none have been identified as having the necessary specificity to be used independently of other factors in this respect. However the accumulation of current evidence regarding genetic variations, especially the single nucleotide polymorphisms (SNPs) of cytokines and other innate immunity determinants, partially explains the susceptibility and individual differences of patients with regard to the evolution of sepsis. This article outlines the role of genetic variation of some serum proteins which have the potential to be used as biomarker values in evaluating sepsis susceptibility and the progression of the condition.

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Section: Cytokinesmentioning

confidence: 99%

The Relevance of Coding Gene Polymorphysms of Cytokines and Cellular Receptors in Sepsis

Georgescu

Grigorescu

Chirteș

et al. 2017

The Journal of Critical Care Medicine

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“…There was statistically significant positive correlation between CRP and Presepsin (r=0.658, P value=0.000) as shown in table(3).…”

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confidence: 78%

“…The evaluation of sepsis severity and outcome is complicated by the lack of gold standard for the diagnosis of sepsis and the variability in its presentation (2) . Many scores and biomarkers had been studied in this perspective, with Acute Physiology and Chronic Health Evaluation II (APACHE II) score being traditionally used for this clinical situation (3) .…”

Section: Introductionmentioning

confidence: 99%

Diagnosis of Sepsis among Adult Patients with AML Using Scd14

Ghonaim¹,

Haggag²,

Hosny³

2021

The Egyptian Journal of Hospital Medicine

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Background: Millions of dead cases are reported every year due to sepsis. Sepsis has been estimated in 1-2 % of hospitalized patients especially leukemic patients. The diagnosis of sepsis remains a clinical challenge. Many studies suggest that presepsin plays a role in diagnosing sepsis, but the results remain controversial. Objective: To evaluate the potential of presepsin as an early biochemical marker of sepsis in adult acute leukemic patients and to assess the correlation between severity of sepsis and level of presepsin. Comparing between presepsin & CRP in diagnosing bacterial infection in critically ill adult leukemic patients. Patients and Methods: This study was conducted on 24 patients having acute leukemia after receiving chemotherapy and 24 controls at Medical Oncology and Clinical Pathology Departments, Zagazig University Hospitals during the period from June 2018 to August 2019. Results: There was statistically significant difference between patients and control regarding presepsin levels. The highest levels of presepsin were in patients with septic shock followed by severe sepsis, sepsis, SIRS then control group. There was statistically significant difference between types of sepsis and presepsin (P value = 0.000). There was statistically significant positive correlation between CRP and presepsin (r = 0.658). AT cut off value of 440 the clinical sensitivity of presepsin was 82.5% and its clinical specificity was 90%, AUC was 0.89. On comparing these results with the normal cut off value of CRP level (6), the clinical sensitivity and specificity were 90% & 61% respectively and AUC was 0.70. Conclusion:Presepsin can be used as a better indicator to the degree of severity of sepsis than CRP in septic adult leukemic patients.

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“…The examination of the balance between pro-and antiinflammatory cytokines serves as a predictive marker in clinical practice (45). The mortality of the patients with sepsis is related to elevated TNF-α and IL-10 concentrations (46,47). The IL-10: TNF-α ratio is low in surviving patients (47), so it has been assumed that TNF-α/IL-10 disbalance represents one of the triggering factors for the development of SIRS and polyorgan failure in the initial stage after burn injury (48).…”

Section: Discussionmentioning

confidence: 99%

Melatonin attenuates oxidative stress and modulates inflammatory response after experimental burn trauma

Hristova¹,

Bekyarova²,

Atanasova³

et al. 2018

JMMS

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Introduction. Thermal injury activates an inflammatory response. Melatonin possesses antioxidant and anti-inflammatory properties. The objective of the present work was to study melatonin effects on the inflammatory response under conditions of oxidative stress during the early stage of thermal injury. Materials and methods. We used 24 white male rats of Wistar breed, randomly divided into three experimental groups. Group one was the control, group two was inflicted with burn trauma, and group three was inflicted with burn trauma, with melatonin application following the thermal injury. Melatonin was applied twice in doses of 10 g/kg b.m. immediately after the burn trauma and again at 12 hours. Plasma levels of tumor necrosis-factor-α (TNF-α), a pro-inflammatory mediator, and of interleukin-10 (Il-10), an anti-inflammatory mediator, were examined and their ratio was calculated. The levels of malondialdehyde (MDA), an oxidative stress marker, were also estimated. Results. Thermal trauma significantly increased plasma TNF-α levels (ð<0.01) and TNF-α /IL-10 ratio but did not change IL-10 ones. Plasma MDA concentrations were significantly elevated as well (ð<0.0001). Melatonin application significantly reduced TNF-α (ð<0.05), increased IL-10 (ð<0.05), down-regulated TNF-α/IL-10 ratio and changed MDA concentrations (ð<0.01). In conclusion, our results show that local alteration induces oxidative stress and inflammatory response with TNF-α /IL-10 disbalance. Melatonin modulates this response and attenuates oxidative stress in experimental burn injury.

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Prognostic value of cytokines (TNF-α, IL-10, Leptin) and C-reactive protein serum levels in adult patients with nosocomial sepsis

Cited by 7 publications

References 18 publications

The Relevance of Coding Gene Polymorphysms of Cytokines and Cellular Receptors in Sepsis

The Relevance of Coding Gene Polymorphysms of Cytokines and Cellular Receptors in Sepsis

Diagnosis of Sepsis among Adult Patients with AML Using Scd14

Melatonin attenuates oxidative stress and modulates inflammatory response after experimental burn trauma

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