Mortality in Patients of the Glasgow Blood Pressure Clinic

Isles, Christopher; Walker, Louise; Beevers, Gareth; Brown, Ivan; Cameron, Helen; Clarke, John; Hawthorne, Victor M.; Hole, David; Lever, A. F.; Robertson, James Louis; Wapshaw, Jean A.

doi:10.1097/00004872-198604000-00003

Cited by 237 publications

(100 citation statements)

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“…Exercise testing also helps to identify treated hypertensive patients with 'controlled' resting office BP, but uncontrolled exercise BP, 15 who may continue to have further target organ damage and adverse outcome. [16][17][18] An exercise test may unmask abnormal underlying haemodynamics pathognomonic of the hypertension disease process. Hypertensive individuals have impaired peripheral vasodilation during exercise and this leads to uncontrolled BP rise.…”

Section: Discussionmentioning

confidence: 99%

How well do office and exercise blood pressures predict sustained hypertension? A Dundee Step Test Study

2000

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Exercise systolic blood pressure (BP) appears to be a better predictor of cardiac mortality than casual office BP. We tested whether this could be explained by exercise systolic BP being a better predictor of sustained hypertension than casual office BP. Exercise systolic BP was measured using the lightweight 3-min single stage, submaximal Dundee Step Test in 191 consecutive subjects (102 male, age 52 (s.d. 13) years) who were referred to a specialist hypertension clinic for assessment. Exercise systolic BP was compared with office BP and daytime ambulatory BP (ABP). Sustained hypertension was defined as a mean daytime systolic and/or diastolic ABP of у140/90 mm Hg. Receiver operating characteristic (ROC) curves of exercise systolic BP and office BP in predicting sustained hypertension were compared. The positive predictive value of office diastolic BP у90 mm Hg and office systolic BP у140 mm Hg for sustained hypertension were 64% and 67%

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Section: Discussionmentioning

confidence: 99%

How well do office and exercise blood pressures predict sustained hypertension? A Dundee Step Test Study

2000

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“…There is evidence that, in patients receiving antihypertensive treatment, cardiovascular risk is determined more strongly by the blood pressure achieved during treatment than by the initial blood pressure. 6,8 Thus, in the case-control study described above, 6 the risk of stroke was more than halved in patients in whom antihypertensive treatment resulted in a systolic blood pressure of less than 140 mm Hg, compared with those in whom systolic blood pressure remained above 160 mm Hg; by contrast, there was no significant association between baseline blood pressure and the risk of stroke in treated patients. Similarly, in a study of 3783 patients attending the Glasgow Blood Pressure Clinic, the lowest mortality rates in patients of all ages were seen in those in whom the greatest reductions in blood pressure were achieved ( Figure 2).…”

Section: Figurementioning

confidence: 94%

“…Similarly, in a study of 3783 patients attending the Glasgow Blood Pressure Clinic, the lowest mortality rates in patients of all ages were seen in those in whom the greatest reductions in blood pressure were achieved ( Figure 2). 8 While the benefits of antihypertensive therapy are undisputed, there is as yet no evidence that these benefits are related to any specific drug action; it appears to be the lowering of blood pressure itself that is beneficial. 3 Recent evidence for this comes from the Second Swedish Trial in Old Patients with Hypertension (STOP-Hypertension-2).…”

Section: Figurementioning

confidence: 99%

The problem of uncontrolled hypertension

Lindholm

2002

J Hum Hypertens

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“…1 One of the possible explanations is the fact that hypertension is quite frequently associated with other cardiovascular risk factors, eg, lipid disorders, obesity, and diabetes. 2 A variety of antihypertensive drugs are now available for the treatment of hypertension.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the effects of fixed combinations of sustained-release verapamil/trandolapril versus captopril/hydrochlorothiazide on metabolic and electrolyte parameters in patients with essential hypertension

Cífková

Nakov²,

Novozámská

et al. 2000

J Hum Hypertens

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The objective of this randomised open, active controlled, cross-over study was to evaluate the effect of a fixed combination of verapamil SR/trandolapril compared to captopril/hydrochlorothiazide on serum lipids, lipoproteins, and other metabolic and electrolyte parameters in patients with essential hypertension. Another objective was to assess the efficacy and safety of both combinations. One hundred hypertensives with systolic blood pressure 140-209 mm Hg and diastolic blood pressure 90-119 mm Hg were evaluated after 16 weeks receiving a fixed combination of verapamil SR 180 mg/ trandolapril 2 mg (VT) or captopril 50 mg/hydrochlorothiazide 25 mg (CH) both given once daily. Lipids and lipoproteins were assessed in duplicate on 2 consecutive days. The study was completed by 80 patients. There was no statistically significant difference between the two combined regimens with respect to low-density lipoprotein (LDL)-cholesterol for the 'intention-to-treat'

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Mortality in Patients of the Glasgow Blood Pressure Clinic

Cited by 237 publications

References 0 publications

How well do office and exercise blood pressures predict sustained hypertension? A Dundee Step Test Study

How well do office and exercise blood pressures predict sustained hypertension? A Dundee Step Test Study

The problem of uncontrolled hypertension

Evaluation of the effects of fixed combinations of sustained-release verapamil/trandolapril versus captopril/hydrochlorothiazide on metabolic and electrolyte parameters in patients with essential hypertension

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