Mortality in hospitalized HIV-infected patients in a referral center in Bahia, Brazil

Nascimento, Luca; Improta-Caria, Alex Cleber; Brites, Carlos

doi:10.1016/j.bjid.2022.102716

The Brazilian Journal of Infectious Diseases

2022

DOI: 10.1016/j.bjid.2022.102716

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Mortality in hospitalized HIV-infected patients in a referral center in Bahia, Brazil

Luca Nascimento¹,

Alex Cleber Improta-Caria²,

Carlos Brites³

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2023

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“…The cause of shock in AIDS patients with dTSM may be More and more research has confirmed that septic shock is a risk factor for the death of AIDS patients. [25][26][27][28] Among HIV patients infected with Talaromyces marneffei in Beijing Ditan Hospital, septic shock accounted for 10.2% of the total death causes, ranking fourth. 29 A prediction result of hospitalization mortality of HIV/AIDS patients with Talaromyces marneffei infection in Guangxi showed that septic shock was the most important predictor of patient death.…”

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Clinical Characteristics Associated with Poor Prognosis of Acquired Immunodeficiency Syndrome Patients Complicated with Disseminated Talaromycosis marneffei

Wu,

Pan,

2023

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To analyze the clinical characteristics of AIDS with dTSM, especially in patients with poor prognosis. Patients and Methods: One hundred and seventy AIDS patients were enrolled in this single-center retrospective study. The epidemiological characteristics, clinical manifestations, laboratory tests, imaging examination, and treatment outcome were collected. Logistic regression analysis was used to estimate the risk of mortality in AIDS patients with dTSM. The predictive value was evaluated using the receiver operating characteristic (ROC) curve. Results: From 2015 to 2022, the incidence of AIDS with dTSM in the Wenzhou region increased yearly, mainly in young adults. The mortality rate was 16.47%. The most common clinical manifestations were lymph-node enlargement (92.35%) and fever (78.24%). Multivariate logistic regression analysis showed that procalcitonin (PCT), blood urea nitrogen (BUN), shock, and antiretroviral therapy (ART) were the risk factors for poor outcomes. The model comprised four risk factors and showed an excellent prediction performance, with an AUC of 0.987 in the training cohort (95% CI: 0.946-0.999) and 0.976 in the validation cohort (95% CI: 0.887-0.999). Conclusion:This study suggested that PCT, BUN, shock, and ART were associated with the prognosis and outcome of AIDS with dTSM and had a specific predictive value.

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confidence: 99%

Clinical Characteristics Associated with Poor Prognosis of Acquired Immunodeficiency Syndrome Patients Complicated with Disseminated Talaromycosis marneffei

Wu,

Pan,

2023

IDR

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Mortality in hospitalized HIV-infected patients in a referral center in Bahia, Brazil

Cited by 1 publication

References 17 publications

Clinical Characteristics Associated with Poor Prognosis of Acquired Immunodeficiency Syndrome Patients Complicated with Disseminated Talaromycosis marneffei

Clinical Characteristics Associated with Poor Prognosis of Acquired Immunodeficiency Syndrome Patients Complicated with Disseminated Talaromycosis marneffei

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