Clinical Characteristics Associated with Poor Prognosis of Acquired Immunodeficiency Syndrome Patients Complicated with Disseminated Talaromycosis marneffei

Abstract

To analyze the clinical characteristics of AIDS with dTSM, especially in patients with poor prognosis. Patients and Methods: One hundred and seventy AIDS patients were enrolled in this single-center retrospective study. The epidemiological characteristics, clinical manifestations, laboratory tests, imaging examination, and treatment outcome were collected. Logistic regression analysis was used to estimate the risk of mortality in AIDS patients with dTSM. The predictive value was evaluated using the receiver operating characteristic (ROC) curve. Results: From 2015 to 2022, the incidence of AIDS with dTSM in the Wenzhou region increased yearly, mainly in young adults. The mortality rate was 16.47%. The most common clinical manifestations were lymph-node enlargement (92.35%) and fever (78.24%). Multivariate logistic regression analysis showed that procalcitonin (PCT), blood urea nitrogen (BUN), shock, and antiretroviral therapy (ART) were the risk factors for poor outcomes. The model comprised four risk factors and showed an excellent prediction performance, with an AUC of 0.987 in the training cohort (95% CI: 0.946-0.999) and 0.976 in the validation cohort (95% CI: 0.887-0.999). Conclusion:This study suggested that PCT, BUN, shock, and ART were associated with the prognosis and outcome of AIDS with dTSM and had a specific predictive value.

Characteristics and risk factors for death in HIV-positive talaromycosis marneffei patients with sepsis

“…Over the past 20 years, TSM has progressed from a rare disease to a common co-infection in HIV patients, and studies have confirmed that TSM can increase the mortality rate of HIV patients, which is a severe threat to human life and health [ 8 ]. A number of studies have analyzed factors associated with poor prognosis of HIV-positive TSM patients [ 7 , [12] , [13] , [14] , [15] , [16] , [17] ]. However, there is a lack of research on the prognosis of severe HIV/AIDS patients with TSM.…”