Mortality in Captive Bighorn Sheep — Clinical, Hematological, and Pathological Observations

Woolf, Alan; Kradel, David C.

doi:10.7589/0090-3558-9.1.12

Cited by 15 publications

(12 citation statements)

References 4 publications

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“…9,13 Remarkably, the only detailed study on reactive amyloidosis in small ruminants was done in wild bighorn sheep and in captive Dall sheep, where a pathologic condition similar to the one described in this study was presented. 11,18,45 We found in our sheep and goat that, as previously observed in these species as well as in cows, 16,18,26,33,39 bighorn sheep, 11 and Dorcas gazelles, 32 the organ most involved was the kidney. The kidney was the only organ harboring macroscopic lesions that consisted of miliary foci on the cortical surface of the kidney and, on cut surfaces, radial striations located only in the renal cortex.…”

Section: Discussionsupporting

confidence: 65%

Pathology of AA Amyloidosis in Domestic Sheep and Goats

et al. 2003

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We describe the main pathologic changes in small ruminants affected by AA amyloidosis, together with the partial sequence of the protein involved. Twenty-one sheep and one goat were selected for presenting macroscopic kidney lesions compatible with systemic amyloidosis. Available tissue samples were studied by histologic, immunopathologic, and ultrastructural means. Renal lesions were characterized grossly by pale cortical surfaces with scattered, miliary, whitish-yellow foci and on cut cortical surfaces by straight, whitish-yellow striations. Gangrenous pneumonia was observed in 16 out of 21 affected sheep (76.2%), although other chronic inflammations were also observed. Amyloid was detected in all grossly affected kidneys using Congo red staining, lesions being most remarkable in glomeruli, affecting 95.5% of animals studied. Congophilic deposits were also observed in intertubular interstitium (68.2%) and medulla (57.1%). All amyloid-affected animals presented proximal convoluted tubule lesions, mostly characterized by an increase in diameter and by hyaline granular degeneration that were responsible for the macroscopic appearance of the kidney. Histologically, amyloid was also seen in blood vessels, spleen, liver, lymph nodes, gastrointestinal tract, and adrenal glands. All amyloid deposits demonstrated greenish-yellow birefringence with polarized light, and the antisera prepared against goat amyloid extracts specifically reacted with birefringent congophilic deposits of both sheep and goats. Ultrastructurally, these deposits were formed by masses of straight, nonbranching fibrils located predominantly in the basement membranes of glomerular capillaries and in the mesangium. Partial sequence of the protein in sheep and goats indicated a high degree of homology with the previously reported sequence of sheep Serum Amyloid A.

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Section: Discussionsupporting

confidence: 65%

Pathology of AA Amyloidosis in Domestic Sheep and Goats

et al. 2003

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“…9,13 Remarkably, the only detailed study on reactive amyloidosis in small rumi-nants was done in wild bighorn sheep and in captive Dall sheep, where a pathologic condition similar to the one described in this study was presented. 11,18,45 We found in our sheep and goat that, as previously observed in these species as well as in cows, 16,18,26,33,39 bighorn sheep, 11 and Dorcas gazelles, 32 the organ most involved was the kidney. The kidney was the only organ harboring macroscopic lesions that consisted of miliary foci on the cortical surface of the kidney and, on cut surfaces, radial striations located only in the renal cortex.…”

Section: Discussionsupporting

confidence: 69%

“…This finding is in contrast to the pattern of AA deposition in other species of small ruminants, as well as horses and experimental rodents, where amyloid was found to be most pronounced in spleen, liver, adrenal glands, and gastrointestinal tract. 9,11,22,40,45,47 This difference in tissue distribution of AA amyloid among animal species suggests that particular host factors, e.g., accessory molecules such as proteoglycans that codeposit with the amyloidogenic protein, 37 may be involved in this phenomenon. Alternatively, the presence of multiple, SAA isoforms in sheep and goats, such as found in mice, cows, and humans, may account for organ selectivity.…”

Section: Discussionmentioning

confidence: 99%

Pathology of AA Amyloidosis in Domestic Sheep and Goats

Ménsua

2003

Veterinary Pathology

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Abstract. We describe the main pathologic changes in small ruminants affected by AA amyloidosis, together with the partial sequence of the protein involved. Twenty-one sheep and one goat were selected for presenting macroscopic kidney lesions compatible with systemic amyloidosis. Available tissue samples were studied by histologic, immunopathologic, and ultrastructural means. Renal lesions were characterized grossly by pale cortical surfaces with scattered, miliary, whitish-yellow foci and on cut cortical surfaces by straight, whitish-yellow striations. Gangrenous pneumonia was observed in 16 out of 21 affected sheep (76.2%), although other chronic inflammations were also observed. Amyloid was detected in all grossly affected kidneys using Congo red staining, lesions being most remarkable in glomeruli, affecting 95.5% of animals studied. Congophilic deposits were also observed in intertubular interstitium (68.2%) and medulla (57.1%). All amyloid-affected animals presented proximal convoluted tubule lesions, mostly characterized by an increase in diameter and by hyaline granular degeneration that were responsible for the macroscopic appearance of the kidney. Histologically, amyloid was also seen in blood vessels, spleen, liver, lymph nodes, gastrointestinal tract, and adrenal glands. All amyloid deposits demonstrated greenish-yellow birefringence with polarized light, and the antisera prepared against goat amyloid extracts specifically reacted with birefringent congophilic deposits of both sheep and goats. Ultrastructurally, these deposits were formed by masses of straight, nonbranching fibrils located predominantly in the basement membranes of glomerular capillaries and in the mesangium. Partial sequence of the protein in sheep and goats indicated a high degree of homology with the previously reported sequence of sheep Serum Amyloid A.

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“…Mycoplasma agalactiae, the main causative agent of CA, was isolated from Spanish ibex (Capra pyrenaica hispanica) (9) and detected in roe deer (2). Mycoplasma arginini was also detected in Spanish ibex (9) and bighorn sheep (Ovis canadensis) causing, among others aetiological agents, fatal pneumonia (19). In Poland, specific antibodies to M. agalactiae have not been detected in domestic sheep and goats (5), whereas the epizootic situation for Mccp is not known.…”

Section: Introductionmentioning

confidence: 99%

Screening of the Cervidae family in Poland for Mycoplasma species

Dudek

Bednarek

Szacawa

et al. 2016

Journal of Veterinary Research

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Introduction: Several Mycoplasma species can cause severe diseases in ruminant hosts, some of which are the diseases listed by the World Organisation for Animal Health (OIE). The role of the Cervidae family in carrying and transmitting ruminant mycoplasma infections in Poland is unknown. Material and Methods: Antibody and antigen detection tests for the main mycoplasma species that can affect wild ruminants were performed on 237 samples (serum, nasal swab, bronchoalveolar lavage, and lung) collected from 161 animals during 2011-2014. The samples were obtained from a cull of healthy population of deer which included: 96 red deer (Cervus elaphus elaphus), 19 fallow deer (Dama dama), and 46 roe deer (Capreolus capreolus). Results: Serological screening tests revealed positive reactions to Mycoplasma bovis in one sample and to Mycoplasma capricolum subsp. capripneumoniae in three samples; however, these three samples were negative by immunoblotting. Other antibody and antigen detection tests demonstrated negative results. Conclusion: Currently wild cervids in Poland do not play a significant role in transmitting mycoplasma infections to domestic animals, but they remain a potential risk.

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Mortality in Captive Bighorn Sheep — Clinical, Hematological, and Pathological Observations

Cited by 15 publications

References 4 publications

Pathology of AA Amyloidosis in Domestic Sheep and Goats

Pathology of AA Amyloidosis in Domestic Sheep and Goats

Pathology of AA Amyloidosis in Domestic Sheep and Goats

Screening of the Cervidae family in Poland for Mycoplasma species

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