Mortality in amnestic mild cognitive impairment

Hunderfund, Andrea N. Leep; Roberts, Rosebud O.; Slusser, Tiffani C.; Leibson, Cynthia L.; Geda, Yonas E.; Ivnik, Robert J.; Tangalos, E. G.; Petersen, Ronald C.

doi:10.1212/01.wnl.0000244430.39969.5f

Cited by 60 publications

(48 citation statements)

References 21 publications

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“…A prospective community study of the Mayo Clinic Group demonstrated an increased mortality in subjects with aMCI compared to normal control subjects over a six-year follow-up. Mortality was greater in mdMCI than in aMCI [56]. A recent review reported a non significant increase in mortality for subjects with MCI compared to cognitively intact subjects [51].…”

Section: Mortalitymentioning

confidence: 95%

Mild Cognitive Impairment: A Systematic Review

Mariani

Monastero

Mecocci

2007

JAD

204

180

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Abstract. MCI is a nosological entity proposed as an intermediate state between normal aging and dementia. The syndrome can be divided into two broad subtypes: amnestic MCI (aMCI) characterized by reduced memory, and non-amnestic MCI (naMCI) in which other cognitive functions rather than memory are mostly impaired. aMCI seems to represent an early stage of AD, while the outcomes of the naMCI subtypes appear more heterogeneous -including vascular dementia, frontotemporal dementia or dementia with Lewy bodies-but this aspect is still under debate. MCI in fact represents a condition with multiple sources of heterogeneity, including clinical presentation, etiology, and prognosis. To improve classification and prognosis, there is a need for more sensitive instruments specifically developed for MCI as well as for more reliable methods to determine its progression or improvement. Current clinical criteria for MCI should be updated to include restriction in complex ADL; also the diagnostic and prognostic role of behavioral symptoms and motor dysfunctions should be better defined. A multidisciplinary diagnostic approach including biological and neuroimaging techniques may probably represent the best option to predict the conversion from MCI to dementia. In this review we discuss the most recent aspects related to the epidemiological, clinical, neuropathological, neuroimaging, biochemical and therapeutic aspects of MCI, with specific attention to possible markers of conversion to dementia.

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Section: Mortalitymentioning

confidence: 95%

Mild Cognitive Impairment: A Systematic Review

Mariani

Monastero

Mecocci

2007

JAD

204

180

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“…To date, there have been very few studies reporting on MCI and mortality [41,42] . Further, varying concepts and definitions of MCI and different methods of calculating the mortality risk have made it difficult to compare studies.…”

Section: Mortalitymentioning

confidence: 99%

“…Further, varying concepts and definitions of MCI and different methods of calculating the mortality risk have made it difficult to compare studies. For example, Hunderfund et al [42] assessed the hazard of death in subjects with and without MCI subtypes that require decline in memory. Over a median follow-up of 5.7 years, persons with MCI had increased mortality compared with non-impaired persons (HR = 1.7; 95% CI = 1.3-2.3).…”

Section: Mortalitymentioning

confidence: 99%

Mortality in Individuals with Mild Cognitive Impairment

Guehne¹,

Luck²,

Busse³

et al. 2007

Neuroepidemiology

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Objective: This study aimed to investigate whether mortality is higher for individuals suffering from Mild Cognitive Impairment (MCI). Methods: A community sample of 1,045 dementia-free individuals aged 75 years and over was examined using neuropsychological tests over a 4.5-year period. Data were analyzed with the Cox proportional hazards model after having been adjusted for age, gender, and incident dementia. Results: Association between MCI and mortality was examined subject to varied diagnostic criteria of MCI. We found an increased risk of death that was about 1.5 times higher for individuals with MCI when a cognitive performance of more than 1.5 standard deviation below the mean of age- and education-matched controls was required and the criterion of a cognitive complaint was excluded. Males were at about a 40% increased risk of death. Risk also increased with age by about 8% per year. Incident dementia showed a significant influence on mortality only if it became manifest by 1.5 years after the baseline measurement (follow-up 1). Conclusion: MCI is associated with increased mortality when certain diagnostic criteria are applied.

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“…Low cognitive scores in childhood and early adulthood, usually on intelligence tests, have been shown to be associated with shortened survival Hart et al, 2005;Holsinger et al, 2007;Kuh et al, 2004;Martin and Kubzansky, 2005;Whalley and Deary, 2001). On the other hand, cognition in the elderly has also been shown to be associated with mortality (Bassuk et al, 2000;Bennett et al, 2002;Dewey and Saz, 2001;Eagles et al, 1990;Fried et al, 1998;Gale et al, 1996;Gussekloo et al, 1997;Hassing et al, 2002;Hunderfund et al, 2006;Kelman et al, 1994;Korten et al, 1999;Liu et al, 1990;Neale et al, 2001;Nguyen et al, 2003;Palmer et al, 2002;Shipley et al, 2006;Small et al, 2003;Small and Backman, 1997;Smits et al, 1999;Swan et al, 1995;Tuokko et al, 2003). Besides age, a major difference between these two strands of research is the conceptualisation of cognitive function.…”

Section: Introductionmentioning

confidence: 99%

Does cognition predict mortality in midlife? Results from the Whitehall II cohort study

Sabia

Guéguen

Marmot

et al. 2010

Neurobiology of Aging

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The authors examined the association of 'g' (general intelligence) factor and 5 specific cognitive measures assessed in 1997-1999 with mortality till 2006 (mean follow-up of 8 years) in the middleaged Whitehall II cohort study. In age-and sex-adjusted analysis, a decrease in one standard-deviation in memory (Hazard Ratio (HR)=1.19, 95% Confidence Interval (CI): 1.02, 1.39) and in AH4-I (HR=1.16, 95%CI: 1.01, 1.35) was found to be associated with higher mortality. The association with 'g' factor, phonemic and semantic fluency did not reach significance at p<0.05. No association was found with vocabulary. Out of education, health behaviours and health measures, it was health behaviours that explained the greater part of the association between cognition and mortality, ranging from 21% for memory to 70% for semantic fluency. All the covariates taken together explained only 26% of the association with memory and between 33-90% for the other cognitive measures. This study suggests that 'g' type composite measure of cognition might not be enough to understand the associations between cognition and health.

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Mortality in amnestic mild cognitive impairment

Abstract: Amnestic mild cognitive impairment is associated with increased mortality, which is greater in multiple-domain aMCI than in single-domain aMCI. Mortality in aMCI subtypes may vary by APOE-epsilon4 allele status.

Cited by 60 publications

References 21 publications

Mild Cognitive Impairment: A Systematic Review

Mild Cognitive Impairment: A Systematic Review

Mortality in Individuals with Mild Cognitive Impairment

Does cognition predict mortality in midlife? Results from the Whitehall II cohort study

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