Mortality in Individuals with Mild Cognitive Impairment

Guehne, Uta; Luck, Tobias; Busse, Anja; Angermeyer, Matthias C.; Riedel‐Heller, Steffi G.

doi:10.1159/000112479

Cited by 37 publications

(12 citation statements)

References 89 publications

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“…These results support the association between MCI and increased risk of death, but the effect was strongest for multiple-domain MCI [26]. Other researchers have found that both the presence of cognitive impairment and the severity are associated with risk of dementia and mortality [11,27].…”

Section: Discussionsupporting

confidence: 79%

Cause of death in mild cognitive impairment: a prospective study (NEDICES)

Contador

Bermejo‐Pareja

Mitchell

et al. 2013

Euro J of Neurology

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BACKGROUND AND PURPOSE Previous studies have reported the occurrence of increased mortality rates among individuals with mild cognitive impairment (MCI), but possible links between MCI subtypes and cause-specific mortality need to be explored. To examine short-term mortality (5-years), long-term mortality (13-years) and cause-specific mortality of individuals over 65 years of age) suffering from mild cognitive impairment (MCI) compared to cognitively unimpaired individuals in the NEDICES (Neurological Disorders in Central Spain) cohort. METHODS MCI was classified using standardized psychometric and functional assessment in accordance with diagnostic convention. Cox's proportional hazards models, adjusted by sociodemographic and comorbidity, were used to assess the risk of death at 5 and 13 years of MCI subtypes compared with a reference group of elders without cognitive impairment (N = 2,329). Causes of death were obtained from the National Population Register of Spain. RESULTS There were 1,484 deceased individuals at 13 years. MCI subtypes were defined as amnestic-single domain (N = 259), amnestic-multiple domain (N = 197), and non-amnestic (N = 641). After adjusting for covariates, only amnestic-multiple domain MCI showed an increased hazard ratio (HR) for mortality at 5 years versus reference group. However, the HR for mortality at 13-years was increased for all MCI subtypes. The HR by MCI subtype was 1.19 in non-amnestic (95% CI: 1.05 to 1.36), 1.31 in amnestic-single domain (95% CI: 1.10 to 1.56) and 1.67 in amnestic multiple domain (95% CI: 1.38 to 2.02). In terms of cause specific mortality, the chance of death from dementia was statistically higher in all MCI subtypes. CONCLUSION Amnestic-multiple domain MCI showed the greatest risk of mortality in comparison with other MCI subtypes at different intervals. Dementia was the only cause-specific mortality that was increased in MCI individuals.

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Section: Discussionsupporting

confidence: 79%

Cause of death in mild cognitive impairment: a prospective study (NEDICES)

Contador

Bermejo‐Pareja

Mitchell

et al. 2013

Euro J of Neurology

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“…The relative risk for MCI patients in comparison to nonaffected subjects varied from 1.0 to 1.9. Furthermore, Guehne et al [6] found an increased risk of death, about 1.5 times higher in patients with MCI, when certain diagnostic criteria are applied. Likewise, Steenland et al [44] have shown that the mortality of MCI patients is 50–100% higher than the mortality of controls.…”

Section: Discussionmentioning

confidence: 99%

“…Other psychogeriatric diseases in elderly patients have likewise been reported to entail increased mortality. Thus, mild cognitive impairment brings an increased risk of death [5,6]. In nondemented subjects with mental illness such as schizophrenia, schizoaffective disorders, bipolar affective disorders and depression substantially higher mortality has been reported [7].…”

Section: Introductionmentioning

confidence: 99%

Survival in a Large Elderly Population of Patients with Dementia and Other Forms of Psychogeriatric Diseases

Nilsson

Gustafson²,

Hultberg³

2011

Dement Geriatr Cogn Disord

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Background: Dementia and other psychogeriatric diseases in elderly patients bring an increased risk of death. Better knowledge of prognosis in elderly patients affected by dementia or mental illness should be of great importance in order to improve care plans and assist in medical decisions. Methods: We have investigated the survival time in 2,112 patients with dementia and other forms of psychogeriatric diseases, enrolled during 1990 to 2005 and followed up until 2009, and the influence of diagnoses, plasma homocysteine level, presence of vascular disease and renal impairment. Results: The survival time after diagnosis in most diagnostic groups is about a third compared to an average population of similar age and sex. Age was the main predictor of survival time in all patients. Conclusions: All diagnoses, except in patients with subjective cognitive impairments, showed an increased mortality. These estimates can be used for prognosis and planning for patients, carers, service providers and policy makers.

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“…Up to now, such measures are rarely available as most respective instruments target populations at advanced old age [8][9][10][11] . For instance, in the Cardiovascular Determinants of Dementia (CASCADE) study the age range was 65-75 years [8] , in the Memory and Morbidity in Augsburg Elderly (MEMO) study it was 65+ years [9] , in the Leipzig Longitudinal Study of Ageing (LEILA75+) it was 75+ years [10] , and in the Asset and Health Dynamics among the Oldest Old (AHEAD) study it was 70+ years [11] .…”

Section: Introductionmentioning

confidence: 99%

Population-Based Distribution and Psychometric Properties of a Short Cognitive Performance Measure in the Population-Based Heinz Nixdorf Recall Study

Wege

Dlugaj²,

Siegrist

et al. 2011

Neuroepidemiology

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Background: Providing a valid and sensitive measure of different domains of cognitive performance in epidemiologic studies of early old-age populations presents a methodological challenge, given the broad range of variability in cognitive functioning in this age group. Objectives: (1) To provide data on the distribution of cognitive performance scores in a representative sample of an early old-age population, and (2) to assess psychometric properties of a short cognitive performance measure developed within the framework of a cohort study. Design: Population-based cohort study. Setting and Participants: As part of the second examination of the Heinz Nixdorf Recall Study, 4,145 participants aged 50–80 years underwent a short cognitive performance assessment composed of 5 subtests with a mean duration of 7.31 min. Additionally, a subsample of 656 participants had a detailed neuropsychological and neurological examination. Methods: Age- and education-specific cognitive performance scores in the total sample were calculated. Based on data from the subsample, concurrent validity was examined by comparing findings with a clinically validated neuropsychological assessment. Results: In the total sample, younger and more highly educated participants had higher scores of cognitive performance. In the subsample, a good accuracy [area under the curve (AUC) = 0.81 (0.74–0.87)] of the short cognitive performance assessment compared with results from a clinically established Alzheimer disease assessment scale and diagnosis of mild cognitive impairment [AUC = 0.82 (0.78–0.82)] was observed. Conclusion: This brief, cognitive performance measure, documenting good psychometric properties, can be useful in future epidemiological investigations exploring different domains and overall cognitive functioning in early old-age populations.

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Mortality in Individuals with Mild Cognitive Impairment

Cited by 37 publications

References 89 publications

Cause of death in mild cognitive impairment: a prospective study (NEDICES)

Cause of death in mild cognitive impairment: a prospective study (NEDICES)

Survival in a Large Elderly Population of Patients with Dementia and Other Forms of Psychogeriatric Diseases

Population-Based Distribution and Psychometric Properties of a Short Cognitive Performance Measure in the Population-Based Heinz Nixdorf Recall Study

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