Mortality from liver disease in the West Midlands, 1993-2000: observational study

Gastroenterology services in the UK. The burden of disease, and the organisation and delivery of services for gastrointestinal and liver disorders: a review of the evidence

“…415 Other studies have reported increases of 350% in England from 1970 to 1998, 416 and 112% in the West Midlands from 1993 to 2000. 417 This contrasts with a fall of almost 30% in the EU average cirrhosis mortality rate of 14 to 10 per 100 000 from 1970 to 1998. Together with a rise in national alcohol consumption, 320 321 and in hospital admissions for alcoholic liver disease, 220 the increase in cirrhosis mortality in the UK has led to the recent publication of a national alcohol harm reduction strategy.…”

Guidelines on the management of ascites in cirrhosis

“…Mortality from cirrhosis has increased from 6 per 100 000 population in 1993 to 12.7 per 100 000 population in 2000. 7 Approximately 4% of the general population have abnormal liver function or liver disease 8 and approximately 10-20% of those with one of the three most common chronic liver diseases (non-alcoholic fatty liver disease, alcoholic liver disease, and chronic hepatitis C) develop cirrhosis over a period of 10-20 years. With a rising frequency of alcoholic and non-alcoholic fatty liver disease, a huge increase in the burden of liver disease is expected over the next few years 8 with an inevitable increase in the complications of cirrhosis.…”

Obesity and overweight in relation to liver disease mortality in men: 38 year follow-up of the original Whitehall study

“…[1][2][3] In particular, fatty liver disease is becoming common, with some estimates suggesting that almost one-third of US adults are affected. 4 Despite its increasing prevalence, the aetiology of liver disease is not well understood.…”