Mortality and intestinal failure in surgical necrotizing enterocolitis

Current Research on the Epidemiology, Pathogenesis, and Management of Necrotizing Enterocolitis

“…Probiotics have not eradicated the disease [2] and the surgical outcomes do not appear to have improved over 20 years [3]. The high mortality (around 30% for surgical NEC) [3] and long-term morbidity [4,5] of survivors mandates urgent research into the pathogenesis, diagnosis, prevention, and treatment of this devastating disease. In this review article, it is not our aim to comprehensively describe all new advances in NEC, but instead to describe some areas of progress, focusing wherever possible on clinical studies.…”

Necrotising Enterocolitis - epidemiology and imaging

“…After surgical treatment, mortality may be considerably higher. 144,207,209 Reported risk factors for death in NEC include low birth weight, 85,210 early onset and bleeding tendency, 28 hispanic etnicity, and number of ICD-diagnoses. 85 Extension of necrotic bowel, sepsis and organ failure also contribute to adverse outcome.…”

Stem cells as a potential therapy for necrotizing enterocolitis

“…At present, there are no specific therapies; supportive treatment comprises intestinal rest, antibiotics and medical treatment of systemic consequences. Survivors of acute NEC may have long-term morbidities related both to gut necrosis (e.g., short bowel syndrome [6]) and systemic sequelae (e.g., adverse neurodevelopmental outcome [7]). Given the morbidity and mortality, there is an urgent need for development of strategies to prevent and treat the disease.…”