Mortality and incidence trends from esophagus cancer in selected geographic areas of China circa 1970–90

Li, Ke

doi:10.1002/ijc.10706

Cited by 160 publications

(116 citation statements)

References 14 publications

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“…Amongst the sons of women with cancer, it was the 5 th most common malignancy (7.4%). This difference in incidence between mothers and their children reflects the reduction in the prevalence of esophageal cancer in China (Ke, 2002) The incidence of breast cancer amongst the daughters was much higher than suggested by the NCCR data, together with the findings that when both the father and the daughter were diagnosed with cancers, incidence of breast cancer was also higher than national data (Ju et al, 2013) reflects the increasing incidence of female breast cancer nationwide (Yang et al, 2006). On the other hand, hereditary factors also contributed to these findings.…”

Section: Discussionmentioning

confidence: 99%

Risk of Malignancy Associated with a Maternal Family History of Cancer

Liu

Shu²,

Sheng³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 99%

Risk of Malignancy Associated with a Maternal Family History of Cancer

Liu

Shu²,

Sheng³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…More than 80% of esophageal cancers occur in developing countries, but these malignancies are particularly prevalent in China and other countries in Asian, where esophageal squamous cell carcinoma (ESCC) is most common (1,2). Accumulating evidence shows that a variety of biologic abnormalities including altered gene expression, gene mutations, aberrant signaling pathways, and genetic alterations contribute to the development and progression of ESCCs (3).…”

Section: Introductionmentioning

confidence: 99%

S100A14: Novel Modulator of Terminal Differentiation in Esophageal Cancer

Chen

Sunkel

et al. 2013

Molecular Cancer Research

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Aberrant keratinocyte differentiation is a key mechanism in the initiation of cancer. Because activities regulating differentiation exhibit altered or reduced capacity in esophageal cancer cells, it is vital to pinpoint those genes that control epidermal proliferation and terminal differentiation to better understand esophageal carcinogenesis. S100A14 is a member of the S100 calcium-binding protein family and has been suggested to be involved in cell proliferation, apoptosis, and invasion. The present study used immunohistochemistry analysis of S100A14 in clinical specimens of esophageal squamous cell carcinoma (ESCC) to show that decreased S100A14 is strongly correlated with poor differentiation. Furthermore, both mRNA and protein expression of S100A14 was drastically increased upon 12-O-tetra-decanoylphorbol-13-acetate (TPA) and calcium-induced esophageal cancer cell differentiation. Overexpression of S100A14 resulted in a G 1 -phase cell cycle arrest and promoted calcium-inhibited cell growth. Conversely, decreasing S100A14 expression significantly promoted G 1 -S transition and prevented the morphologic changes associated with calcium-induced cell differentiation. Molecular investigation demonstrated that S100A14 altered the calcium-induced expression of late markers of differentiation, with the most prominent effect on involucrin (IVL) and filaggrin (FLG). Finally, it was determined that S100A14 is transcriptionally regulated by JunB and that S100A14 and JunB status significantly correlated in ESCC tissue. In summary, these data demonstrate that S100A14 is transcriptionally regulated by JunB and involved in ESCC cell differentiation.

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“…Within China, the Taihang mountain region in Hebei, Henan and Shanxi Provinces has the highest incidence and mortality rates, reaching more than 100/100,000/year (2). Efforts are ongoing to identify etiologically associated changes in such high-risk areas, so that more effective cancer prevention, screening, and treatment strategies can be developed.…”

Section: Introductionmentioning

confidence: 99%

p16, MGMT, RARβ2, CLDN3, CRBP and MT1G gene methylation in esophageal squamous cell carcinoma and its precursor lesions

Roth¹,

Abnet²,

Hu³

et al. 2006

Oncol Rep

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Abstract. Esophageal squamous cell carcinoma (ESCC) is a common cancer with a very poor prognosis. New methods are needed to screen high-risk populations and identify curable tumors and precursor lesions early. Molecular markers may be useful in such screening efforts. This study was designed to determine the prevalence of p16, MGMT, RARß2, CLDN3, CRBP and MT1G gene methylation in patients with ESCC to evaluate the variation of gene methylation across a spectrum of preneoplastic lesions, and assess the feasibility of using gene methylation in a primary screening test utilizing frozen esophageal cells collected by balloon cytology samplers. Samples were obtained from high-risk subjects from north central China. These samples included 11 foci of histologically normal mucosa, 8 foci of low-grade squamous dysplasia, 7 foci of high-grade squamous dysplasia, and 13 foci of ESCC from 6 fully embedded resection specimens; endoscopic biopsies from 6 individuals with no histological evidence of disease; and frozen esophageal balloon samples from 12 asymptomatic subjects. Promoter CpG site-specific hypermethylation status was determined for each gene using realtime methylation-specific PCR (qMS-PCR) based on Taqman chemistry. Of the 6 ESCC patients, 5 showed methylation of at least one gene. For most genes, methylation occurred with increasing frequency during neoplastic progression, with the largest increase found between low-and high-grade dysplasia. There was considerable variation in methylation patterns among different foci of the same histological grade, even within individual patients, but 16/20 (80%) of high-grade dysplastic and cancer foci had ≥ 2 methylated genes, while 17/19 (89%) of normal and low-grade dysplastic foci had <2 methylated genes. These genes were rarely methylated in histologically normal mucosa from patients with or without ESCC. Gene methylation was common and easily detectable in the frozen esophageal cells collected by balloon cytology samplers. Our data suggest that methylation of p16, MGMT, RARß2, CLDN3, CRBP, and MT1G is common in the esophageal mucosa of patients with ESCC in this high-risk population, and tends to increase in prevalence in foci with increasing histological severity of disease. Methylation data from panels of genes may be able to identify patients with high-grade lesions. Balloon cytology may be able to screen the length of the esophagus effectively for a subset of cells with abnormal methylation, and may be useful in a primary screening test for ESCC and its precursor lesions.

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Mortality and incidence trends from esophagus cancer in selected geographic areas of China circa 1970–90

Cited by 160 publications

References 14 publications

Risk of Malignancy Associated with a Maternal Family History of Cancer

Risk of Malignancy Associated with a Maternal Family History of Cancer

S100A14: Novel Modulator of Terminal Differentiation in Esophageal Cancer

p16, MGMT, RARβ2, CLDN3, CRBP and MT1G gene methylation in esophageal squamous cell carcinoma and its precursor lesions

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