“…The role of S100A14 in tumor underlying mechanisms might be complicated. For example, molecular investigation in ESCC illustrated the mechanism of S100A14 affecting the calcium-induced expression of late markers of differentiation, with the most prominent effect on involucrin and filaggrin (Chen et al 2013). The molecular mechanism involved in S100A14 and differentiation in GC or colorectal cancer are still not clear, whereas, in other tumors, such as epithelial ovarian cancers (Cho et al 2014), hepatocellular carcinoma, and breast cancer, overexpressed S100A14 was not correlated with differentiation, but with proliferation, invasion, metastasis, and even poor prognosis.…”