Mortality and Incidence of Malignancy in Korean Patients with Rheumatoid Arthritis

Kim, Yun Jung; Shim, Jina; Choi, Chan-Bum; Bae, Sang Cheol

doi:10.3899/jrheum.110704

Cited by 31 publications

(41 citation statements)

References 40 publications

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“…Interestingly, in both Chinese studies, overall malignancy risk was not higher in RA patients compared to the general population . This finding was also true in the Korean study . These data suggest that apart from race, geographic and environmental factors may also play a part in influencing the risk of malignancy in RA patients.…”

Section: Discussionsupporting

confidence: 52%

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Incidence and patterns of malignancies in a multi‐ethnic cohort of rheumatoid arthritis patients

et al. 2019

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Aim This study was undertaken to determine the incidence and patterns of malignancies in rheumatoid arthritis (RA) patients in our cohort. Methods Between 2001 and 2013, we analyzed 1117 patients in the prospective Tan Tock Seng Hospital (TTSH) RA Registry. Patients who developed malignancies after the onset of RA were identified from this registry. Age‐ and sex‐adjusted standardized incidence ratios (SIRs) were calculated to compare observed to expected numbers of malignancies based on data from the Singapore Cancer Registry. Results Out of 19 839 person‐years of follow‐up, 132 incident malignancies were diagnosed during the observation period. There were 114 (86.4%) solid‐organ tumors and 18 (13.6%) hematological malignancies. The SIR (95% confidence interval) for all malignancies combined was 1.28 (0.88‐1.87) for males and 1.21 (1.00‐1.46) for females. Compared to the general population, we found a 4‐ to 5‐fold increase in lymphoma among our RA patients compared to the general population (SIR 5.05 [1.90‐13.46] for males and 3.75 [1.95‐7.20] for females). The SIR of lung malignancy in male RA patients is 2.36 (1.23‐4.53) and SIR of cervical malignancy in female RA patients is 3.72 (2.20‐6.23). Conclusion There is a trend toward an overall increased malignancy risk in our RA patients compared to the general population. Specifically, there is an increased risk of lymphomas in all RA patients, lung malignancy in male patients, and cervical malignancy in female patients, compared to the general population.

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Section: Discussionsupporting

confidence: 52%

“…There are limited studies done in Asian populations other than the two Japanese, 1 Taiwanese, one Korean, and a few Chinese studies. Interestingly, in both Chinese studies, overall malignancy risk was not higher in RA patients compared to the general population .…”

Section: Discussionmentioning

confidence: 99%

Incidence and patterns of malignancies in a multi‐ethnic cohort of rheumatoid arthritis patients

et al. 2019

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“…It is not clear whether the overall incidence of malignancies in patients with RA is higher 11,12,13 , lower 14,15 , or the same as in the general population 16,17 . However, malignancy is emerging as one of the least tractable, unexpected, life-threatening complications during the course of RA.…”

Section: Discussionmentioning

confidence: 99%

Incidence of Malignancy and the Risk of Lymphoma in Japanese Patients with Rheumatoid Arthritis Compared to the General Population

Hashimoto

Chiba²,

Tsuno³

et al. 2015

J Rheumatol

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“…The incidence of each type of malignancy depends on multiple genetic and environmental factors; they also differ between ethnicities and geographical regions. Some reports indicate higher rates of certain neoplasms in patients with RA while others demonstrate lower or equivalent rates compared to the general population …”

Section: Introductionmentioning

confidence: 99%

Coexistent malignant conditions in rheumatoid arthritis - A population-based cross-sectional study

et al. 2017

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Mortality and Incidence of Malignancy in Korean Patients with Rheumatoid Arthritis

Abstract: Our study demonstrates that the SMR was slightly higher in patients with RA, but the incidence rates of malignancies were not significantly different from the general population. But deaths from respiratory diseases were significantly higher.

Cited by 31 publications

References 40 publications

Incidence and patterns of malignancies in a multi‐ethnic cohort of rheumatoid arthritis patients

Incidence and patterns of malignancies in a multi‐ethnic cohort of rheumatoid arthritis patients

Incidence of Malignancy and the Risk of Lymphoma in Japanese Patients with Rheumatoid Arthritis Compared to the General Population

Coexistent malignant conditions in rheumatoid arthritis - A population-based cross-sectional study

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