Coexistent malignant conditions in rheumatoid arthritis - A population-based cross-sectional study

Dagan, Amir; Segal, Gad; Tiosano, Shmuel; Watad, Abdulla; Neumann, Shana G.; Comaneshter, Doron; Cohen, Arnon D; Amital, Howard

doi:10.1111/ijcp.12929

Cited by 16 publications

(14 citation statements)

References 46 publications

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“…The study has an observational design and not an interventional one, which is an inherent limitation to any cross‐sectional study of this type. Previous experience with the CHS population‐based study has indicated that the data are of high quality and that the associations that were detected were identical to those that were observed when smaller groups of patients with definite diagnoses were used . Our study revealed statistically significant difference towards medium (but not high) SES among RA patients as compared with controls, but the difference was small and without an overt clinical impact.…”

Section: Discussionsupporting

confidence: 79%

Are obesity and rheumatoid arthritis interrelated?

et al. 2017

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Section: Discussionsupporting

confidence: 79%

Are obesity and rheumatoid arthritis interrelated?

et al. 2017

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“…The CHS database was originally created to accommodate data for clinical proposes, therefore, it was designed to act as a data registry according to diagnostic criteria of disorders but rather to code diseases according to the International Classification of Diseases (ICD) for statistical, economical and administrative purposes. However, the validity of the diagnoses as exhibited in previous studies have been shown to be high and reliable [ 8 , 9 , 20 – 24 ].…”

Section: Discussionmentioning

confidence: 91%

Cross-sectional analysis of the associations between fibromyalgia and diabetes mellitus

Lichtenstein¹,

Tiosano²,

Comaneshter³

et al. 2018

Reumatologia

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BackgroundThe fibromyalgia syndrome (FMS) is a chronic condition consisting of widespread musculoskeletal pain and tenderness together with mood and cognitive dysfunction. Diabetes mellitus (DM) is a common condition causing significant and detrimental morbidity and mortality. Data on the association between the two conditions is scarce and mainly based on small populations therefore lack solid evidence.ObjectivesTo evaluate the association of FMS with DM.Material and methodsThis cross-sectional study used the Clalit Health Services database, the largest Health Maintenance Organization in Israel, serving 4,400,000 members. FMS patients were compared to age- and sex-matched controls regarding chronic comorbid conditions. χ2 and student’s t-tests were used for univariate analysis.ResultsThe study included 14,296 FMS patients and 71,324 age- and sex-matched controls. The FMS group had a significantly higher proportion of DM patients compared to non-FMS controls (19.8% and 17.4 respectively; OR 1.17 , 95% CI: 1.12–1.23, p < 0.001).ConclusionsDM was found to be more common amongst FMS patients compared to matched controls to suggest that the pathophysiology of DM might lead a patient to develop FMS. Consequently, physicians treating DM patients should be aware of the possible risk and asses for clinical signs of FMS in order to diagnose and treat it in time to better their patients’ quality of life and disease management.

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“…In this study, we presented the increased rate of cardiovascular risk factors among RA patients. In some previous reports, we have shown that those patients also tend to have higher rates of ischemic heart disease, gout, COPD, aortic aneurysms, malignancies (in particular non-Hodgkin’s lymphoma), and also psychiatric comorbidities such as bipolar and anxiety disorders [13, 23-25, 35-37]. …”

Section: Discussionmentioning

confidence: 99%

“…The validity of the diagnoses in the registry, which are based on hospital and primary care physicians and specialists’ reports, was found to be high in previous studies [21, 22]. Our group has recently published several papers investigating comorbidities among RA patients based on the CHS database using similar investigational methodology [13, 23-25]. Data withdrawn from the database represent a current situational analysis of co-existing variables and diagnoses without regard to chronology.…”

Section: Methodsmentioning

confidence: 99%

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Stroke among Rheumatoid Arthritis Patients: Does Age Matter? A Real-Life Study

et al. 2017

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Background/Aims: Rheumatoid arthritis (RA) is a chronic, debilitating autoimmune disease that affects the joints and it is known to be associated with cardiovascular morbidity. However, the association between RA and stroke among different age groups has not been explored. The objective of our study was to evaluate the association between RA and stroke in different age strata. Methods: Cross-sectional study, utilizing the database of Israel’s largest healthcare provider. The proportion of stroke was compared between patients diagnosed with RA and age- and gender-matched controls. The study sample was divided into 2 age groups: young (≤65 years) and elderly (>65 years). Multivariable analysis was performed using logistic regression. Results: The study included 11,782 RA patients and 57,973 age- and gender-matched controls. RA patients, primarily young, had more cardiovascular risk factors than controls. Stroke rates were significantly elevated among young RA patients in comparison with controls (3.74 vs. 2.20%, respectively, p < 0.001). In multivariate analysis, RA was found to be independently associated with stroke (OR 1.18, 95% CI 1.09–1.28). Conclusion: RA is independently associated with stroke, especially among RA patients under 65 years, for whom cardiovascular risk factors were more prominent. Physicians should advise RA patients to manage their risk factors strictly.

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Coexistent malignant conditions in rheumatoid arthritis - A population-based cross-sectional study

Abstract: Rheumatoid arthritis is associated with several malignant disorders, in particular non-Hodgkin's lymphoma. Appropriate measures for non-Hodgkin's lymphoma screening in this patient population should be considered.

Cited by 16 publications

References 46 publications

Are obesity and rheumatoid arthritis interrelated?

Are obesity and rheumatoid arthritis interrelated?

Cross-sectional analysis of the associations between fibromyalgia and diabetes mellitus

Stroke among Rheumatoid Arthritis Patients: Does Age Matter? A Real-Life Study

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