Mortality and causes of death of end-stage renal disease in children: A Dutch cohort study

Groothoff, Jaap W.; Gruppen, Mariken; Offringa, Martin; Hutten, Gerard J.; Lilien, Marc R.; Kar, Nicole J. van de; Wolff, E; Davin, Jean Claude; Heymans, H. S. A.

doi:10.1046/j.1523-1755.2002.00156.x

Cited by 339 publications

(288 citation statements)

References 18 publications

(5 reference statements)

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“…Other traditional and nontraditional cardiovascular risk factors, notably BMI, calcium, and phosphorus were not found to be associated with cIMT. The high prevalence of cardiovascular risk factors and greater cIMT in this cohort of children was not unexpected given the increased cardiovascular mortality seen among children with CKD (11,12). Recently published National Heart, Lung, and Blood Institute (NHLBI) consensus guidelines for cardiovascular health and risk reduction in children and adolescents recommend that children with CKD be considered in the highest tier of cardiovascular risk (34) and be managed aggressively to minimize their risk of developing atherosclerosis and subsequent cardiovascular events.…”

Section: Discussionmentioning

confidence: 93%

“…Medial deposition of calcium and phosphorus and the resulting increase in vascular stiffness and BP further contribute to the high prevalence of both hypertension and left ventricular hypertrophy in these children (9). These children are therefore at significant risk for experiencing a cardiovascular event by early adulthood (10); in fact, CVD is the leading cause of death in young adults with childhood-onset ESRD (11,12). Risk identification and reduction is therefore of paramount importance among this group of children.…”

Section: Introductionmentioning

confidence: 99%

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Carotid Intima-Media Thickness in Children with CKD

Brady¹,

Schneider²,

Flynn³

et al. 2012

Clinical Journal of the American Society of Nephrology

102

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SummaryBackground and objectives In adults, increased carotid intima-media thickness (cIMT) as assessed by ultrasonography is a valid predictor of cardiovascular events. Children with CKD are known to be at increased cardiovascular risk. This study sought to identify cardiovascular risk factors associated with increased cIMT in children with CKD. Results The median cIMT was 0.43 mm (interquartile range, 0.38-0.48) compared with 0.41 mm in healthy controls (P=0.03 for difference). After multivariable adjustment, the median cIMT was 0.02 mm (95% confidence interval [CI], 0.01-0.05) larger than that of the healthy controls. In a multivariable linear regression analysis, dyslipidemia and hypertension were associated with 0.05 mm (95% CI, 0.01-0.08) and 0.04 mm (95% CI, 0.003-0.08) greater mean cIMT, respectively. Body mass index, CKD etiology, GFR, birth weight, pubertal status, calcium, phosphorus, sex, and race were not associated with cIMT.Conclusions cIMT is significantly elevated among children with CKD, as is the prevalence of other cardiovascular risk factors. Of these risk factors, hypertension and dyslipidemia are significantly associated with increased cIMT.

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Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Carotid Intima-Media Thickness in Children with CKD

Brady¹,

Schneider²,

Flynn³

et al. 2012

Clinical Journal of the American Society of Nephrology

102

View full text Add to dashboard Cite

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“…Patients were recruited from the database of The National Dutch Registry of patients on renal replacement therapy (RENINE, Rotterdam, The Netherlands) and the database of all centres for pediatric nephrology in The Netherlands. The procedure of the cohort formation has previously been described in detail [10].…”

Section: Methodsmentioning

confidence: 99%

The impact of delayed development on the quality of life of adults with end-stage renal disease since childhood

et al. 2006

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Little is known about the impact of the course of life of children with end-stage renal disease (ESRD) on their quality of life in adulthood. We therefore assessed the course of life of adult patients with onset of ESRD at an age of <15 years between 1972 and 1992 and compared it with that of the general population. Furthermore, we explored how course of life is associated with quality of life (QoL) in young adulthood. A total of 75 young adult patients who had had ESRD since childhood, aged between 20 years and 30 years, completed the RAND-36 Health Survey and a questionnaire, which retrospectively assesses the achievement of development milestones. Patients achieved fewer milestones than peers with respect to autonomy, social, and psycho-sexual development, and displayed less risk behaviour. Patients who achieved fewer social milestones while growing up experienced more emotional problems and less vitality, and they had a lesser overall mental quality of life. Paediatric nephrologists should pay more attention to the development of social and independent functioning of children with ESRD in order to prepare them for active participation in society in adult life.

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“…These structural abnormalities include LV hypertrophy, LV dilation, and impaired systolic function, and each is strongly linked to a poor cardiovascular prognosis (1)(2)(3)(4)(5)(6). Although heart failure and sudden cardiac death are common in CKD, the appropriate management of myocardial disease is not fully understood (7)(8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

Advanced Parameters of Cardiac Mechanics in Children with CKD

Chinali

Matteucci²,

Franceschini

et al. 2015

Clinical Journal of the American Society of Nephrology

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Background and objectives Newer parameters of cardiac mechanics provide additional insights on cardiac dysfunction in adult patients with CKD. The aim of this study was to identify prevalence of subclinical abnormalities in cardiac function through the analysis of novel indices of cardiac mechanics in a large population of children with CKD.Design, setting, participants, & measurements Between 2009 and 2011, the prospective observational Cardiovascular Comorbidity in Children with CKD Study enrolled patients with CKD ages 6-17 years old with eGFR=10-45 ml/min per 1.73 m 2 in 14 European countries. Cardiac morphology and function were assessed through echocardiography. The analysis presented encompasses global radial, longitudinal, and circumferential strains as well as time to peak analysis. Data were compared with 61 healthy children with comparable age and sex.Results Data on 272 patients with CKD with complete echocardiographic assessment are reported (age =12.863.5 years old; 65% boys). Patients with CKD showed mildly higher office BP values and higher prevalence of left ventricular hypertrophy, but no differences were observed among groups in left ventricular ejection fraction. Strain analysis showed significantly lower global radial strain (29.6%613.3% versus 35.5%68.9%) and circumferential strain components (221.8%64.8% versus 228.2%65.0%; both P,0.05) in patients with CKD without significant differences observed in longitudinal strain (215.9%63.4% versus 216.2%63.7%). Lower values of global radial strain were associated with lower circumferential endocardial-to-epicardial gradient (r=0.51; P,0.01). This association remained significant after adjusting for BP, eGFR, and presence of left ventricular hypertrophy. Eventually, patients with CKD also showed higher delay in time to peak cardiac contraction (58628 versus 37618 milliseconds; P,0.05).Conclusions A significant proportion of children with CKD show impaired systolic mechanics. Impaired systolic function is characterized by lower radial strain, transmural circumferential gradient, and mild cardiac dyssynchrony. This study suggests that analysis of cardiac strain is feasible in a large multicenter study in children with CKD and provides additional information on cardiac pathophysiology of this high-risk population.

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Mortality and causes of death of end-stage renal disease in children: A Dutch cohort study

Abstract: Survival in children with ESRD has increased over the last 20 years, but the SMR remains high. Early transplantation and a more vigorous approach toward hypertension and infection may be mandatory in order to further reduce mortality.

Cited by 339 publications

References 18 publications

Carotid Intima-Media Thickness in Children with CKD

Carotid Intima-Media Thickness in Children with CKD

The impact of delayed development on the quality of life of adults with end-stage renal disease since childhood

Advanced Parameters of Cardiac Mechanics in Children with CKD

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