Mortality and cancer incidence among British agricultural pesticide users

Frost, Gillian; Brown, Terry; Harding, Anne-Helen

doi:10.1093/occmed/kqr067

Cited by 48 publications

(55 citation statements)

References 10 publications

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“…In sensitivity analyses restricting our population to those diagnosed more than 5 years after study enrolment, we noted a positive association with use of any OP and multiple myeloma. No association was observed with any individual OP and multiple myeloma in a recent study of AHS applicators,18 though excesses of multiple myeloma have been noted among pesticide applicators and in farming populations 33 48. The findings in our study were based on only a few exposed cases; therefore, further evaluations are needed to confirm these results.…”

Section: Discussioncontrasting

confidence: 58%

Organophosphate insecticide use and cancer incidence among spouses of pesticide applicators in the Agricultural Health Study

et al. 2015

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Objectives Organophosphates (OP) are among the most commonly used insecticides. OPs have been linked to cancer risk in some epidemiologic studies, which have been largely conducted in predominantly male populations. We evaluated personal use of specific OPs and cancer incidence among female spouses of pesticide applicators in the prospective Agricultural Health Study cohort. Methods At enrollment (1993–1997) spouses provided information about ever use of specific pesticides, including ten OPs, demographic information, reproductive health history, and other potential confounders. We used Poisson regression to estimate relative risks (RRs) and 95% confidence intervals (95% CIs) for all cancers diagnosed through 2010 for North Carolina and 2011 for Iowa. Results Among 30,003 women, 25.9% reported OP use, and 718 OP-exposed women were diagnosed with cancer during the follow-up period. Any OP use was associated with an elevated risk of breast cancer (RR = 1.20, 95% CI: 1.01, 1.43). Malathion, the most commonly reported OP, was associated with increased risk of thyroid cancer (RR = 2.04, 95% CI: 1.14, 3.63) and decreased risk of non-Hodgkin lymphoma (RR = 0.64, 95% CI: 0.41, 0.99). Diazinon use was associated with ovarian cancer (RR = 1.87, 95% CI: 1.02, 3.43). Conclusions We observed increased risk with OP use for several hormonally-related cancers, including breast, thyroid, and ovary, suggesting potential for hormonally-mediated effects. This study represents the first comprehensive analysis of OP use and cancer risk among women, and thus a need for further evaluation.

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Section: Discussioncontrasting

confidence: 58%

Organophosphate insecticide use and cancer incidence among spouses of pesticide applicators in the Agricultural Health Study

et al. 2015

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“…The reason is that exposure of these workers to UV radiation is much greater than that experienced by other types of workers because rural workers work outdoors (14) . In addition to sun exposure, one study conducted in England (23) associates contact with pesticides with the onset of diseases, such as melanoma cancer, testicular cancer, and multiple myeloma.…”

Section: Discussionmentioning

confidence: 99%

Skin cancer in rural workers: nursing knowledge and intervention

Cézar-Vaz

Bonow

Piexak

et al. 2015

Rev. esc. enferm. USP

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Objective:To identify the exposure of rural workers to the sun's ultraviolet radiation and pesticides; to identify previous cases of skin cancer; and to implement clinical and communicative nursing actions among rural workers with a previous diagnosis of skin cancer. Method: Observational-exploratory study conducted with rural workers exposed to ultraviolet radiation and pesticides in a rural area in the extreme south of Brazil. A clinical judgment and risk communication model properly adapted was used to develop interventions among workers with a previous history of skin cancer. Results: A total of 123 (97.7%) workers were identified under conditions of exposure to the sun's ultraviolet radiation and pesticides; seven (5.4%) were identified with a previous diagnosis of skin cancer; four (57.1%) of these presented potential skin cancer lesions. Conclusion: This study's results enabled clarifying the combination of clinical knowledge and risk communication regarding skin cancer to rural workers.

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“…134 However, excess risk was found among pesticide applicators in the USA 135 and the UK. 136 Indeed, geographical differences in risk are not entirely unexpected because pesticide applicators are likely to have different exposures in various regions. The results among pesticide applicators suggest that in-depth study of this occupational group might be useful.…”

Section: Occupational Risk Factorsmentioning

confidence: 99%

Adolescent and adult risk factors for testicular cancer

2012

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The incidence of testicular cancer has been increasing over the past several decades in many developed countries. The reasons for the increases are unknown because risk factors for the disease are poorly understood. Some research suggests that exposures in utero or in early childhood are likely to be important in determining an individual's level of risk. However, other research suggests that exposure to various factors in adolecence and adulthood are also linked to the development of testicular cancer. Of these, two occupational exposures—firefighting and aircraft maintenance—and one environmental exposure (to organochloride pesticides) are likely to be associated with increased risk of developing testicular cancer. By contrast, six of the identified factors—diet, types of physical activity, military service as well as exposure to ionizing radiation, electricity and acrylamide—are unlikely to increase the risk of developing testicular cancer. Finally, seven further exposures—to heat, polyvinylchloride, nonionizing radiation, heavy metals, agricultural work, pesticides and polychlorinated biphenyls as well as marijuana use—require further study to determine their association with testicular cancer.

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Mortality and cancer incidence among British agricultural pesticide users

Abstract: This study suggests that pesticide users in the PUHS are generally healthier than the national population but may have excesses of non-melanoma skin cancer, testicular cancer and multiple myeloma.

Cited by 48 publications

References 10 publications

Organophosphate insecticide use and cancer incidence among spouses of pesticide applicators in the Agricultural Health Study

Organophosphate insecticide use and cancer incidence among spouses of pesticide applicators in the Agricultural Health Study

Skin cancer in rural workers: nursing knowledge and intervention

Adolescent and adult risk factors for testicular cancer

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