Morroniside cinnamic acid conjugate as an anti-inflammatory agent

Takeda, Yoshinori; Tanigawa, Naomi; Sunghwa, Fortunatus; Ninomiya, Masayuki; Hagiwara, Makoto; Matsushita, Kazunobu; Koketsu, Mamoru

doi:10.1016/j.bmcl.2010.06.095

Cited by 19 publications

(8 citation statements)

References 24 publications

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“…In a recent study, a morroniside cinnamic acid conjugate was prepared and evaluated on E-selectin mediated cell–cell adhesion as an important role in inflammatory processes. 7- O Cinnamoylmorroniside ( 11 ) exhibited anti-inflammatory activity (IC 50 = 49.3 µM) by inhibiting the expression of E-selectin and was observed to be a potent inhibitor of TNF-α-induced E-selectin expression [ 75 ]. It was also determined that morroniside isolated from the fruits of C. officinalis inhibited the formation of reactive oxygen species (ROS) and lipid peroxidation and down-regulated the expression of NF-κBp65, COX-2 and iNOS which is increased in type-2 diabetic mice [ 69 ].…”

Section: Iridoid Chemistry and Researched Anti-inflammatory Iridoid-cmentioning

confidence: 99%

Anti-Inflammatory Iridoids of Botanical Origin

Viljoen

Mncwangi²,

Vermaak³

2012

CMC

174

110

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Inflammation is a manifestation of a wide range of disorders which include; arthritis, atherosclerosis, Alzheimer’s disease, inflammatory bowel syndrome, physical injury and infection amongst many others. Common treatment modalities are usually non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin, paracetamol, indomethacin and ibuprofen as well as corticosteroids such as prednisone. These however, may be associated with a host of side effects due to non-selectivity for cyclooxygenase (COX) enzymes involved in inflammation and those with selectivity may be highly priced. Thus, there is a continuing search for safe and effective anti-inflammatory molecules from natural sources. Research has confirmed that iridoids exhibit promising anti-inflammatory activity which may be beneficial in the treatment of inflammation. Iridoids are secondary metabolites present in various plants, especially in species belonging to the Apocynaceae, Lamiaceae, Loganiaceae, Rubiaceae, Scrophulariaceae and Verbenaceae families. Many of these ethnobotanicals have an illustrious history of traditional use alluding to their use to treat inflammation. Although iridoids exhibit a wide range of pharmacological activities such as cardiovascular, hepatoprotection, hypoglycaemic, antimutagenic, antispasmodic, anti-tumour, antiviral, immunomodulation and purgative effects this review will acutely focus on their anti-inflammatory properties. The paper aims to present a summary for the most prominent iridoid-containing plants for which anti-inflammatory activity has been demonstrated in vitro and / or in vivo.

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Section: Iridoid Chemistry and Researched Anti-inflammatory Iridoid-cmentioning

confidence: 99%

Anti-Inflammatory Iridoids of Botanical Origin

Viljoen

Mncwangi²,

Vermaak³

2012

CMC

174

110

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“…These findings are in agreement with many literature studies reporting that ethanolic extracts from Caralluma arabica and Caralluma attenuate as close species to our studied plant exhibited significant anti-inflammatory effects via their chemically identified compounds such as luteolin-4%- O -neohesperidoside,lutolin-4%- O -[a-( l -rhamnopyranosyl-(12)-b- d -glucopyranoside)] [ 26 , 27 ]. Propanoic acid identified by GC-MS in the hydroethanol fraction of C. europaea as well as cinnamic acid can be also responsible for the observed anti-inflammatory effects ( Figure 1 and Table 1 ) ( Figure 2 and Table 2 ) [ 28 , 29 , 30 ].…”

Section: Discussionmentioning

confidence: 99%

Caralluma europaea (Guss.) N.E.Br.: Anti-Inflammatory, Antifungal, and Antibacterial Activities against Nosocomial Antibiotic-Resistant Microbes of Chemically Characterized Fractions

et al. 2021

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Caralluma europaea (Guss.) N.E.Br.: (C. europaea) is a wild medicinal plant belonging to the family Apocynaceae. It is commonly used in traditional medicines for treating several diseases. The present work aims to evaluate the anti-inflammatory, antibacterial, and antifungal potentials of C. europaea fractions including hydro ethanol (ET CE), n-butanol (But CE), and polyphenol (Poly CE). The chemical composition of hydroethanol, n-butanol, and polyphenol-rich fractions from C. europaea were determined using GC-MS after silylation. The anti-inflammatory effect of hydroethanol, n-butanol, and polyphenol-rich fractions was studied by carrageenan-induced paw edema. Antibacterial and antifungal activities of hydroethanol, n-butanol, and polyphenol-rich fractions against Gram-positive bacteria, Gram-negative bacteria, and yeasts were assessed using the disc diffusion and micro-dilution assays. The findings of the chemical characterization affirmed the presence of interesting bioactive compounds in C. europaea fractions. The polyphenol-rich fraction was the best inhibitor of edema by75.68% after 6 h of treatment. The hydroethanol fraction was the most active against both bacteria and yeasts. This study contributes to society as it provides potential bioactive compounds in C. europaea extract, which may help in fighting nosocomial antibiotic-resistant microbes.

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“…This finding shows that the morroniside cinnamic acid conjugate inhibits TNF-α-induced E-selectin expression. 54 As an orthosteric agonist of spinal glucagon-like peptide-1 receptors, morroniside can produce desensitization in a neuropathic pain model. 55 Hongmin Yu et al reported that morroniside could reduce melanin synthesis in a co-culture system by inhibiting tyrosinase activity.…”

Section: Othersmentioning

confidence: 99%

Pharmacokinetics and Pharmacodynamics of Morroniside: A Review

Lei

Xiong

et al. 2019

Natural Product Communications

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Morroniside belongs to a group of iridoid glycosides and is the primary active component of Cornus officinalis Sieb. et Zucc. This species is a rich source of iridoid glycosides and has been used as a traditional Chinese medicinal herbs for centuries. In this review, we discuss the pharmacokinetics and pharmacodynamics of morroniside. Morroniside is quickly absorbed and metabolized and is widely distributed throughout the body. It also exerts various pharmacological effects. Numerous pharmacological studies have indicated that morroniside plays a role in protecting the nervous system, treating osteoarthritis, inhibiting platelet aggregation, preventing diabetic angiopathies and renal damage, and reducing bone resorption, among others. Future research need to be conducted in support of the development of morroniside as a potential drug.

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Morroniside cinnamic acid conjugate as an anti-inflammatory agent

Cited by 19 publications

References 24 publications

Anti-Inflammatory Iridoids of Botanical Origin

Anti-Inflammatory Iridoids of Botanical Origin

Caralluma europaea (Guss.) N.E.Br.: Anti-Inflammatory, Antifungal, and Antibacterial Activities against Nosocomial Antibiotic-Resistant Microbes of Chemically Characterized Fractions

Pharmacokinetics and Pharmacodynamics of Morroniside: A Review

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