Morphometry and aberrant morphology of the adult human tricuspid valve leaflets

Lama, Polly; Tamang, Binod Kumar; Kulkarni, Jyoti

doi:10.1007/s12565-015-0275-0

Cited by 17 publications

(13 citation statements)

References 9 publications

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“…They also indicated presence of the "supernumerary", "accessory" or "commissural" cusps, along with the three cusps. The number of these "supernumerary", "accessory" or "commissural" cusps may be 1-2 [2,21,64], 1-3 [66], or 1-4 [29,36,43,60]. In this study, all of the hearts had three eminent cusps and one or two commissural (accessory) cusps.…”

Section: Discussionmentioning

confidence: 68%

Morphology of the atrioventricular valves and related intraventricular structures in the wild pig (Sus scrofa)

et al. 2017

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Morphology of the atrioventricular valves and the intraventricular related structures were observed and the findings were compared broadly to the literature, in the 7 hearts of the wild pigs (Sus scrofa) by applying macroscopic and microscopic techniques. In all hearts examinated, the tricuspid and mitral valves were precise, composing three and two cusps resepectively. The papillary muscles observed in mammalian heart in general were found in both the ventricles, additionaly there were small unnamed papillary muscles in the left ventricle of the three samples. The septomarginal trabecula and false chords were present in the right ventricles, microscopically possessing myocardial fibers, connective tissue and purkinje cells while the false chords were located in all the left ventricles but the septomarginal trabecula was found in the three samples only. Both the connective tissue and purkinje cells were present in these two structures but the myocardial fibers. Presence of the myocardial fibers in the right ventricle may have an effect on the ventricle geometry.

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Section: Discussionmentioning

confidence: 68%

Morphology of the atrioventricular valves and related intraventricular structures in the wild pig (Sus scrofa)

et al. 2017

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“…The mechanical and structural properties of the left side of the heart have been extensively characterized in the literature [10,11,14,16,19,[33][34][35]. In stark contrast, the right side of the heart and its structures have been largely understudied, especially in the context of the antrioventricular leaflets and chords [7,36]. Moreover, side-by-side comparisons of the left and right leaflet mechanics and structure are very scarce [19,34], and similarly those of the chordae tendineae are nonexistent to the authors' current knowledge.…”

Section: Discussionmentioning

confidence: 99%

Comparative mechanical, morphological, and microstructural characterization of porcine mitral and tricuspid leaflets and chordae tendineae

et al. 2019

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Background: Healthy function of tricuspid valve (TV) structures is essential to avoid tricuspid regurgitation (TR) and may significantly improve disease prognosis. Mitral valve (MV) structures have been extensively studied, but little is known about the TV and right-sided heart diseases. Therefore, clinical decisions and finite element (FE) simulations often rely heavily on MV data for TV applications, despite fundamentally different mechanical and physiological environments. Method/Results: To bridge this gap, we performed a rigorous mechanical, morphological, and microstructural characterization of the MV and TV leaflets and chordae in a porcine model. Planar biaxial testing, uniaxial testing, second harmonic generation imaging and Verhoeff Van Gieson staining were performed. Morphological parameters, tissue moduli, extensibility, and anisotropy were quantified and compared. No major differences in leaflet mechanics or structure were found between TV and MV; chordal mechanics, morphology, and structure were found to compensate for anatomical and physiological loading differences between the valves. No differences in chordal mechanics were observed by insertion point within a leaflet; the septal tricuspid leaflet (STL) and posterior mitral leaflet (PML) did not have distinguishable strut chords, and the STL had the shortest chords. Within a valve, chords from septally-located leaflets were more extensible. MV chords were stiffer. Conclusions: This study presents the first rigorous comparative mechanical and structural dataset of MV and TV structures. Valve type and anatomical location may be stronger predictors of chordal mechanics. Chords from septally-located leaflets differ from each other and from their

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“…Recent extensive progress in invasive cardiac diagnostics and treatment procedures has triggered a wave of dozens of heart architecture morphometric anatomical studies. The aim of these studies is to better understand the cardiac clinical anatomy, and increase the safety and effectiveness of medical interventions (S anchez-Quintana et al 2002;Ho & McCarthy, 2010;Noheria et al 2013;Hołda et al 2015;Klimek-Piotrowska et al 2015;Lama et al 2015).…”

Section: Introductionmentioning

confidence: 99%

Influence of different fixation protocols on the preservation and dimensions of cardiac tissue

et al. 2016

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Recent extensive progress in invasive cardiac procedures has triggered a wave of dozens of heart morphometric anatomical studies that are carried out largely using autopsied samples fixed in formaldehyde solution prior to observations and measurements. In reality, very little is known about changes in heart tissue dimensions during fixation. The aim of this study was therefore to investigate how fixation affects the dimensions of cardiac tissue, and if different types and concentrations of reagents affect this phenomenon. A total of 40 pig heart samples were investigated, and seven different measuring sites were permanently marked in every heart prior to fixation. Four study groups (n = 10 each) were assembled that differed only in concentration and the type of fixative: (i) 2% formaldehyde solution; (ii) 4% formaldehyde solution (formalin); (iii) 10% formaldehyde solution; (iv) alcoholic formalin. The samples were measured before and after fixation at the following time points: 24 h, 72 h and 168 h. It was found that different fixatives significantly affected different parameters. Almost all of the heart dimensions that were measured stabilized after 24 h; later changes were statistically insignificant in the point-to-point comparison. Change in the length of the interatrial septum surface was not altered significantly in any of the fixatives after 24 h of preservation. It was found that 10% formaldehyde increased the thickness of muscular tissue only after 24 h; this thickening was reduced after 72 h and was insignificant at 168 h. Other heart parameters in this group do not present significant changes over the entire fixation time duration. In conclusion, the 10% formaldehyde phosphate-buffered solution appeared to be the best fixative among the fixatives that were studied for cardiac morphometric purposes; this solution caused the smallest changes in tissue dimensions. Measurements should be obtained at least after 1 week of preservation when most parameters exhibit the smallest changes compared with the non-preserved samples.

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Morphometry and aberrant morphology of the adult human tricuspid valve leaflets

Cited by 17 publications

References 9 publications

Morphology of the atrioventricular valves and related intraventricular structures in the wild pig (Sus scrofa)

Morphology of the atrioventricular valves and related intraventricular structures in the wild pig (Sus scrofa)

Comparative mechanical, morphological, and microstructural characterization of porcine mitral and tricuspid leaflets and chordae tendineae

Influence of different fixation protocols on the preservation and dimensions of cardiac tissue

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