Morphometric human embryonic brain features according to developmental stage

Kobayashi, Ami; Ishizu, Koji; Yamada, Shigehito; Uwabe, Chigako; Kose, Katsumi; Takakuwa, Tetsuya

doi:10.1002/pd.4786

Cited by 3 publications

(3 citation statements)

References 20 publications

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“…Several measurements [width of cerebrum (BT) (Figure 2c), length and height of the cerebellum (Figure 12a, b), and length of the midbrain (Figure 10b)] were similar to those reported by a previous study using MRI mid-sagittal sections and histological assessments during the embryonic period (Desmond & O'Rahilly, 1981;Kobayashi et al, 2016). All four measurements increased linearly across and correlated highly with the CRL (r = 0.91-0.96) on MRI scans in the embryonic period.…”

Section: Comparison With Mri and Histological Studiessupporting

confidence: 82%

Morphology and morphometry of the human early foetal brain: A three‐dimensional analysis

et al. 2021

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Morphometric analyses in the early foetal phase (9-13 postconceptional week) are critical for evaluating normal brain growth. In this study, we assessed sequential morphological and morphometric changes in the foetal brain during this period using high-resolution T1-weighted magnetic resonance imaging (MRI) scans from 21 samples preserved at Kyoto University. MRI sectional views (coronal, mid-sagittal, and horizontal sections) and 3D reconstructions of the whole brain revealed sequential changes in its external morphology and internal structures. The cerebrum's gross external view, lateral ventricle and choroid plexus, cerebral wall, basal ganglia and thalamus, and corpus callosum were assessed. The development of the cerebral cortex, white matter microstructure, and basal ganglia can be well-characterized using MRI scans. The insula became apparent and deeply impressed as brain growth progressed.A thick, densely packed cellular ventricular/subventricular zone and ganglionic eminence became apparent at high signal intensity. We detected the emergence of important landmarks which may be candidates in the subdivision processes during the early foetal period; the corpus callosum was first detected in the sample with crownrump length (CRL) 62 mm. A primary sulcus on the medial part of the cortex (cingulate sulcus) was observed in the sample with CRL 114 mm. In the cerebellum, the hemispheres, posterolateral fissure, union of the cerebellar halves, and definition of the vermis were observed in the sample with CRL 43.5 mm, alongside the appearance of a primary fissure in the sample with CRL 56 mm and the prepyramidal fissure in the sample with CRL 75 mm. The volumetric, linear, and angle measurements revealed the comprehensive and regional development, growth, and differentiation of brain structures during the early foetal phase. The early foetal period was neither morphologically nor morphometrically uniform. The cerebral proportion (length/height) and the angle of cerebrum to the standard line at the lateral view of the cerebrum, which may reflect the growth and C-shape formation of the cerebrum, may be a candidate for subdividing the early foetal period. Future precise analyses must establish a staging system for the brain during the early foetal period. This study provides insights into brain structure, allowing for a correlation with functional maturation and facilitating the early detection of brain damage and abnormal development. | 499TAKAKUWA eT Al.

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Section: Comparison With Mri and Histological Studiessupporting

confidence: 82%

Morphology and morphometry of the human early foetal brain: A three‐dimensional analysis

et al. 2021

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“…Morphometric data, according to human embryonic stages, are also valuable for connecting and comparing sonographic data, which is known as “sonoembryology” (Blaas, ). The digital data in our studies could contribute to improvements in prenatal diagnostics by detailing and comparing suitable markers for estimating developmental growth during earlier embryonic stages (Kobayashi et al, ).…”

Section: Resultsmentioning

confidence: 99%

“… [1] Nakashima et al , [2] Kobayashi et al , [3–5] Shiraishi et al , [6] Shiraishi et al , [7] Taketani et al , [8] Yoshida et al, in press, [9] Takakuwa et al, , [10] Mehemed et al, , [11] Kishimoto et al, , [12,13] Toyoda et al, , [14] Kagurasho et al, , [15] Ozeki‐Sato et al, a, [16] Ozeki‐Sato et al, , [17] Osaka et al, , [18] Ueno et al, , [19] Kaigai et al, . [20] Nako et al, , [21] Ueda et al, , [22,23] Hirose et al, , 2016, [24] Hamabe et al, , [25] Kanahashi et al, , [26] Endo et al, , [27] Takakuwa et al, , [28] Shiraishi et al, .…”

Section: Methodsmentioning

confidence: 99%

3D Analysis of Human Embryos and Fetuses Using Digitized Datasets From the Kyoto Collection

Takakuwa

2018

The Anatomical Record

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Three-dimensional (3D) analysis of the human embryonic and early-fetal period has been performed using digitized datasets obtained from the Kyoto Collection, in which the digital datasets play a primary role in research. Datasets include magnetic resonance imaging (MRI) acquired with 1.5 T, 2.35 T, and 7 T magnet systems, phase-contrast X-ray computed tomography (CT), and digitized histological serial sections. Large, high-resolution datasets covering a broad range of developmental periods obtained with various methods of acquisition are key elements for the studies. The digital data have gross merits that enabled us to develop various analysis. Digital data analysis accelerated the speed of morphological observations using precise and improved methods by providing a suitable plane for a morphometric analysis from staged human embryos. Morphometric data are useful for quantitatively evaluating and demonstrating the features of development and for screening abnormal samples, which may be suggestive in the pathogenesis of congenital malformations. Morphometric data are also valuable for comparing sonographic data in a process known as "sonoembryology." The 3D coordinates of anatomical landmarks may be useful tools for analyzing the positional change of interesting landmarks and their relationships during development. Several dynamic events could be explained by differential growth using 3D coordinates. Moreover, 3D coordinates can be utilized in mathematical analysis as well as statistical analysis. The 3D analysis in our study may serve to provide accurate morphologic data, including the dynamics of embryonic structures related to developmental stages, which is required for insights into the dynamic and complex processes occurring during organogenesis. Anat Rec, 301:960-969, 2018. © 2018 Wiley Periodicals, Inc.

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Three-Dimensional Analyses of Human Organogenesis

Takakuwa

2021

Multidisciplinary Computational Anatomy

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Morphometric human embryonic brain features according to developmental stage

Cited by 3 publications

References 20 publications

Morphology and morphometry of the human early foetal brain: A three‐dimensional analysis

Morphology and morphometry of the human early foetal brain: A three‐dimensional analysis

3D Analysis of Human Embryos and Fetuses Using Digitized Datasets From the Kyoto Collection

Three-Dimensional Analyses of Human Organogenesis

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