Morphometric Features of the Elements of the Hemomicrocirculatory Bed in the Cortex of the Adrenal Glands Influenced by the Food Additives Complex

Abstract

The aim: To establish the dynamics of changes in the average total diameter, the diameter of the lumen of microvessels in the cortex of the rats’ adrenal glands influenced by the long-term action food additives complex. Materials and methods: To determine the structural changes of the vessels of the hemomicrocirculatory bed of the cortex of the adrenal glands of rats in our study, we used histological, morphometric and statistical methods. Results: During the study, we found that the effect of a food additive complex on the vessels of the adrenal glands cortex of rats leads to a violation of hemodynamic conditions in the early stages of the experiment. Conclusions: arterioles, venules and capillaries as a capacitive link of the hemomicrocirculatory bed are actively involved in response to exogenous administration of a complex of food additives (sodium glutamate, sodium nitrite, and ponso 4 R). Processes of change of morphometric indicators of vessels are observed mainly from the fourth week of the experiment.

Structural Organization of the Adrenal Glands Medulla of Rats in Normal and After Influence of Food Additive Complex

“…According to literature sources, the response of HMCB to external and internal environmental factors is quite specific. Therefore, during the morphological study of HMCB elements, we analyzed the total diameter of arteries, venules and capillaries, the lumen of these vessels and the average thickness of their walls [5][6]. In particular, we paid attention to the uneven thick- ening of the walls of arterioles, venules and capillaries, which manifested itself in the form of swelling and disorganization of the connective tissue surrounding these vessels.…”

“…Receptors of thyroid hormones of the thyroid gland are expressed on the nuclear membranes of all body cells, which determines the wide spectrum of action of these hormones [1,2,3]. Thyroid hormones affect all types of metabolism, stimulate oxidative processes, affect the absorption of oxygen by cells, maintain water-salt balance, stimulate cell differentiation and proliferation, indirectly regulate carbohydrate metabolism, affect the contractility of the myocardium, the heart rate and the tone of blood vessels [4,5,6]. The wide variability of clinical manifestations of dysfunctions of the thyroid gland itself or disorders of the function of its hormones is associated with such a wide…”

Immunohistochemical Characteristics of Structural Changes in the Cortex and Medulla of the Adrenal Glands Under the Influence of a Food Additive Complex

“…Food additives are needed to maintain the attractive appearance and long-term food storage. More than a thousand existing food additives can be found on supermarket shelves without the consumer even knowing about their existence [5][6]. Not all manufacturers list additional harmful food additives in their products.…”

Morphological and Functional State of the Adrenal Glands of Rats in Normal Conditions and Changes in the Diameters of the Cortical Substance and Medulla After Exposure of a Food Additive Complex

“…They give food products specific taste properties, extend their shelf life and give them an attractive appearance. The consumer of such products does not think and often does not know about the presence of chemical additives in food products, which, even in small quantities, can affect the function of organs and systems, and in this case, the adrenal glands [1,2,3].…”