Morphometric Evaluation of Benign Prostatic Hyperplasia

Correlations between Parameters in Uroflowmetry and Histological Compositions in Patients with Benign Prostatic Hyperplasia

“…Specimens obtained by TURP were prepared with routine hema toxylin and eosin staining, and quantitative morphometric analysis was performed by light-microscopic stereological analysis on a mi crocomputer as reported previously [4][5][6][7][8], The volume fractions of the following tissue components were determined: (1) smooth mus cle; (2) fibrous tissue, and (3) glandular components: glandular epi thelium plus glandular lumina.…”

“…The relationship between the symptomatology of BPH and its histological composition has been investigated by sever al authors [4][5][6][7][8]. Increase in stromal tissue component in BPH compared with that in normal prostatic tissue has been demonstrated [4][5][6], According to Shapiro et al [9], the clinical efficacy of a-adrenergic blockers depends on the proportion of smooth muscle elements in BPH tissue.…”

Age-Related Changes of Histological Composition in Established Benign Prostatic Hyperplasia

“…The static component is primarily related to prostatic enlargement, whereas the dynamic component is related to the tone of prostatic smooth muslce [14], BPH is a benign proliferative process of the stromal and epithelial elements of the prostate. Stereological and com puter-assisted morphological analyses of human prostates have been reported by several authors [6][7][8][9]. According to Lepor et al [15], the severity of bladder outflow obstruc tion and the clinical efficacy of alpha-1-blockers in pa- The role of serum hormones on induction and mainte nance of BPH remains controversial.…”

“…The diagnosis of BPH was confirmed by microscopic histological find ings. Morphometric analyses were performed by light-microscopic stereological analysis as described in the literature [6,7,12], The vol ume fractions of the following five tissue components were deter mined: (1) Smooth muscle cell (SM); (2) fibrous tissue (FT); (3) glan dular cell (GC); (4) glandular lumen (GL), and (5) vascular tissue including vascular lumen (VT). The stromal (SM ± FT) and the glan dular (GL + GC) components were assessed and the stromal-to-epithelial ratio, (SM + FT)/GC were calculated.…”

“…A total of 30 systematic test areas were analyzed for each histological section at a magnification of 400 x. By the stereological principle, area distribution appears to be proportional to volume dis tribution [6,7], All results are expressed as mean ± SEM. Statistics were per formed with the statdview 4.0 program (Abacus Concept Inc., USA).…”