Age-Related Changes of
Histological Composition in
Established Benign Prostatic
Hyperplasia

Ishigooka, Manabu; Hayami, Shinsuke; Suzuki, Yasuhiro; Hashimoto, Tohru; Sasagawa, Isoji; Nakada, Teruhiro

doi:10.1159/000473724

Cited by 7 publications

(9 citation statements)

References 24 publications

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“…Such methodology provides objective and reproducible values for several morphological structures and thus allows statistical comparison. There have been several reports about the morphometry of the normal prostate ( Bartsch et al ., 1 979; Shapiro et al ., 1997 ), but most attention has been on BPH ( Deering et al ., 1994 ; Marks et al ., 1994 ; Robert et al ., 1995 ; Ishigooka et al ., 1996 ). In these studies, the comparison has been made between hyperplasic prostates and normal prostates from men under 40 years of age.…”

Section: Discussionmentioning

confidence: 99%

“…Although morphological quantitation of normal prostates has been reported ( Bartsch et al ., 1 979; Shapiro et al ., 1997 ), these studies were performed in men under 40 years of age. Quantitative studies in benign prostatic hyperplasia (BPH) ( Siegel et al ., 1990 ; Ishigooka et al ., 1996 ; Shapiro et al ., 1997 ) have usually been made in ageing men, however, the control prostates used in these studies were commonly from men younger than 40 years of age.…”

Section: Introductionmentioning

confidence: 99%

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Morphometric evaluation of the human prostate

et al. 2001

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In order to clarify the ageing-related histological changes in the human prostate, a quantitative morphometric analysis was performed. Complete prostates were obtained at autopsy from 281 men (aged 20-84 years) who died in traffic accidents and presented no clinical symptoms of prostatic disease. The prostates were classified as: histologically normal (n=182), with nodular hyperplasia (n=42), with intraepithelial neoplasia (n=40) and carcinomatous with low Gleason grade (n=20). Each prostate was divided into three regions (periurethral, central and peripheral) and the volume of each region, as well as the average volume occupied by stroma and epithelium in each region were quantified. For each parameter, the average values for each age group were compared. In the histologically normal prostates, an increase with ageing in the total volume and the volume occupied by the central region were observed; these increases were mainly caused by an increase in the stromal volume of the central region in men after 30 years of age. No histologically normal prostates were found in men older than 70 years of age. Nodular prostatic hyperplasia was found in men over 30 years of age and a fluctuation in the total volume throughout ageing was observed. Prostates with intraepithelial neoplasia (PIN) and carcinoma were observed in men aged >20 years and the total volume and those of each prostatic region showed multiple variations, except for the eighth decade where a marked increase with regard to that of the previous decades was observed.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Morphometric evaluation of the human prostate

et al. 2001

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“…A maior freqüência de hiperplasia estromal observada neste estudo (31,1%) está de acordo com a literatura humana, a qual afirma que esta afecção tem origem no estroma da glân-dula prostática (Shapiro et al, 1992ab;Ishigooka et al, 1996;Kurimoto et al, 1998 , 1984;Barsanti e Finco, 1989). Com base neste dado, a observação da maior quantidade de estroma na prós-tata de cães acima de cinco anos (que já atingiram a maturidade sexual), permitiu o diagnóstico de hiperplasia estromal, e não de um processo fisiológico, que ocorre com o avançar da idade.…”

Section: Discussão E Conclusõesunclassified

“…Zirkin e Strandberg (1984) relatam que a média de idade entre os cães com HPB é de 6,4 anos, embora a maioria dos autores concorde que algum grau de hiperplasia é evidente em animais acima de quatro anos e a incidência aumenta com o avançar da idade, sendo que cerca de 80% dos cães adultos e idosos possuem próstatas aumentadas (Barsanti e Finco, 1989;Jubb et al, 1993;Johnston et al, 2000). Todos os cães com HPB deste estudo eram adultos ou idosos.…”

Section: Discussão E Conclusõesunclassified

“…A próstata hiperplásica pode variar de pequena e fibromuscular a uma glândula grande com áreas císticas (Weijers et al, 1997). Nos casos mais graves, o aumento prostático pode resultar em estenose uretral, retenção urinária, cistite, glomerulonefrite e hidronefrose (Jubb et al, 1993).Não é claro se ocorre aumento do número, tamanho das cé-lulas prostáticas ou ambos nas HPB (Johnston et al, 2000). Na espécie canina, ao contrário da humana, a hiperplasia é 1 Projeto financiado pela FAPESP ** Faculdade de Medicina Veterinária e Zootecnia, UNESP, Botucatu.…”

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