Morphometric Characteristics of Cell Structures in the Substantia Nigra in Humans

Salkov, V N; Khudoerkov, R. M.; Воронков, Д. Н.

doi:10.1007/s11055-017-0406-2

Cited by 2 publications

(2 citation statements)

References 11 publications

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“…Thus, changes in the size of epithelial cells are important for the detection of cellular mechanisms in the pathogenesis of GP. It is reasonable to assert that the measurement of the parameters of epithelial cells in combination with the indices of their nuclei reflects the functional activity of the hereditary apparatus in GP, which was proven by scientists studying other human cells [22,23].…”

Section: Resultsmentioning

confidence: 99%

Changes in the Cytomorphometric Indices in Epitheliocytes of the Oral Mucosa of Patients with Generalized Periodontitis

2019

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For the study of some mechanisms of the pathogenesis of generalized periodontitis, there were examined 64 patients who were divided into the following groups: Group I – 12 healthy people (6 men and 6 women); Group ІІ – 40 patients with grade I generalized periodontitis (20 men and 20 women) and Group ІІІ – 12 patients with grade II-III generalized periodontitis (6 men and 6 women). On the cytological preparations of buccal epitheliocytes of the oral mucosa stained with aceto-orcein, 100 nucleus-containing epitheliocytes were examined with the help of microscope “Axioskop”, a company Zeizz, with a 1000×magnification. Cytomorphometric characteristics were studied: the perimeter and the cell surface area, the perimeter and the surface area of the nucleus, and the ratio of the surface area of the nucleus to the cell surface area. In all the patients with generalized periodontitis, the perimeter and cell area and the perimeter and epithelial cell nuclei area (p<0.05 – p<0.001) as well as the nuclear-cytoplasmic correlation reduced significantly, especially in men, that could be regarded as compensatory changes at the cellular level. According to the parameters of cells of epitheliocytes, and especially their nuclei, in both healthy people and patients with generalized periodontitis, gender differences were identified, especially in Group ІІІ. Thus, it could be argued that the measurement of the perimeter and the area of cells of buccal epitheliocytes and their nuclei reflects the functional activity of the hereditary apparatus in the patients with generalized periodontitis.

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Section: Resultsmentioning

confidence: 99%

Changes in the Cytomorphometric Indices in Epitheliocytes of the Oral Mucosa of Patients with Generalized Periodontitis

2019

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“…Тельца Леви, если их расценивать как патоморфологический маркер БП, наиболее характерны для черной субстанции (ЧС) среднего мозга, но они также обнаруживаются в двигательных ядрах блуждающего нерва, базальных ядрах Мейнерта, голубом пятне и располагаются диффузно в других структурах на более поздних сроках болезни [6,9,10]. При этом агрегаты α-Syn могут быть маркерами и других нейродегенеративных заболеваний -деменции с тельцами Леви, мультисистемной атрофии, нейродегенераций с накоп лением железа и т.д.…”

Section: α-Syn: агрегаты отложения и тельца левиunclassified

The role of alpha-sinuclein in the neurodegenerative process

Sobolev¹,

Khudoerkov²

2019

Clin. Exp. Morphology

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Длительное время внимание исследователей, изучающих нейродегенеративные заболевания, в первую очередь болезнь Паркинсона (БП), было направлено на небольшой по размеру белок-альфа-синуклеин. Альфа-синуклеин (α-Syn) составляет до 1% от общего белка цитозоля, что можно объяснить его большим значением во внутриклеточных процессах [1]. Молекула α-Syn состоит из трех частей: N-концевой спирали, центрального участка и отрицательно заряженного C-участка [1]. N-концевой участок обеспечивает липофильные свойства, что способствует фиксации белка с мембранными структурами с образованием липопротеиновых комплексов. Центральный участок молекулы взаимодействует с другими молекулами

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Morphometric Characteristics of Cell Structures in the Substantia Nigra in Humans

Cited by 2 publications

References 11 publications

Changes in the Cytomorphometric Indices in Epitheliocytes of the Oral Mucosa of Patients with Generalized Periodontitis

Changes in the Cytomorphometric Indices in Epitheliocytes of the Oral Mucosa of Patients with Generalized Periodontitis

The role of alpha-sinuclein in the neurodegenerative process

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