Morphometric Changes Induced by Amino Acid Supplementation in Skeletal and Cardiac Muscles of Old Mice

Corsetti, Giovanni; Pasini, Evasio; D’Antona, Giuseppe; Nisoli, Enzo; Flati, Vincenzo; Assanelli, Deodato; Dioguardi, Francesco Saverio; Bianchi, Rossella

doi:10.1016/j.amjcard.2008.02.078

Cited by 67 publications

(68 citation statements)

References 32 publications

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“…Electron microscopic (EM) analyses reveal that the volume of mitochondria within skeletal muscle declines by 66% with age when compared with younger counterparts (38). Similar EM findings are documented in a human study, revealing a 25% decrease in the density of mitochondria within the vastus lateralis muscle of males and females aged greater than 60 years (39).…”

Section: Alternation In Mitochondrial Content and Morphology With Agingsupporting

confidence: 65%

Mitochondrial Biogenesis in Skeletal Muscle: Exercise and Aging

Damirchi¹,

Babaei²,

Gholamali³

et al. 2012

Skeletal Muscle - From Myogenesis to Clinical Relations

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Section: Alternation In Mitochondrial Content and Morphology With Agingsupporting

confidence: 65%

Mitochondrial Biogenesis in Skeletal Muscle: Exercise and Aging

Damirchi¹,

Babaei²,

Gholamali³

et al. 2012

Skeletal Muscle - From Myogenesis to Clinical Relations

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“…With aging, ATP production under low-energy conditions is reduced in muscle (Chen Scarabelli et al 2008), possibly due to declining mitochondrial function and content (Mansouri et al 2006;Corsetti et al 2008;Figueiredo et al 2008). In addition, old rats reportedly have decreased AMPK activity in muscle upon acute stimulation with AICAR and treadmill exercise (Reznick et al 2007), and exhibit reduced basal AMPK phosphorylation in muscle (Qiang et al 2007; however, see Thomson and Winder 2009).…”

mentioning

confidence: 99%

AMPK agonist AICAR improves cognition and motor coordination in young and aged mice

et al. 2014

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Normal aging can result in a decline of memory and muscle function. Exercise may prevent or delay these changes. However, aging-associated frailty can preclude physical activity. In young sedentary animals, pharmacological activation of AMP-activated protein kinase (AMPK), a transcriptional regulator important for muscle physiology, enhanced spatial memory function, and endurance. In the present study we investigated effects of AMPK agonist 5-aminoimidazole-4-carboxamide riboside (AICAR) on memory and motor function in young (5-to 7-wk-old) and aged (23-mo-old) female C57Bl/6 mice, and in young (4-to 6-wk-old) transgenic mice with muscle-specific mutated AMPK a2-subunit (AMPK-DN). Mice were injected with AICAR (500 mg/kg) for 3-14 d. Two weeks thereafter animals were tested in the Morris water maze, rotarod, and open field. Improved water maze performance and motor function were observed, albeit at longer duration of administration, in aged (14-d AICAR) than in young (3-d AICAR) mice. In the AMPK-DN mice, the compound did not enhance behavior, providing support for a muscle-mediated mechanism. In addition, microarray analysis of muscle and hippocampal tissue derived from aged mice treated with AICAR revealed changes in gene expression in both tissues, which correlated with behavioral effects in a dose-dependent manner. Pronounced up-regulation of mitochondrial genes in muscle was observed. In the hippocampus, genes relevant to neuronal development and plasticity were enriched. Altogether, endurance-related factors may mediate both muscle and brain health in aging, and could play a role in new therapeutic interventions.

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“…Furthermore, chronic oral essential amino acids (EAA) administered in aged rats significantly increased the expression and activation of mTOR and, possibly, mTOR activated metabolic pathways, which may lead to increased protein synthesis [145]. Further recent evidences revealed the important antiaging role of chronic EAA supplementation in mammals.…”

Section: Oral Supplementation Of Special Mixture Of Aminoacids Maintamentioning

confidence: 99%

“…Recent data show that oral supplementation of special mixture of aminoacids maintains the integrity and function of the muscle, induces mitochondriogenesis, contains ROS production and inhibits apoptosis [145]. Furthermore, chronic oral essential amino acids (EAA) administered in aged rats significantly increased the expression and activation of mTOR and, possibly, mTOR activated metabolic pathways, which may lead to increased protein synthesis [145].…”

Section: Oral Supplementation Of Special Mixture Of Aminoacids Maintamentioning

confidence: 99%

Nutrition, Nitrogen Requirements, Exercise and Chemotherapy-Induced Toxicity in Cancer Patients. A puzzle of Contrasting Truths?

Flati¹,

Corsetti²,

Pasini³

et al. 2015

ACAMC

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Amino acids can modulate cell metabolism and control cell fate by regulating cell survival and cell death. The molecular mechanisms involved are mediated by the mTOR complexes mTORC1 and mTORC2 activity. These complexes are finely regulated and the continuous advancement of the knowledge on their composition and function is revealing that their balance may represent the condition that determines the cell fate. This is important for normal healthy cells but it is becoming clear, and it is even more important, that the balance of the mTORCs activity may also condition the cell fate of cancer cells. Here, we discuss the evidences supporting the amino acids supplementation as a cancer fighting weapon and a possible strategy to counteract the myocyte toxicity associated with chemotherapy, possibly by tipping the balance of mTORCs activity.

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Morphometric Changes Induced by Amino Acid Supplementation in Skeletal and Cardiac Muscles of Old Mice

Cited by 67 publications

References 32 publications

Mitochondrial Biogenesis in Skeletal Muscle: Exercise and Aging

Mitochondrial Biogenesis in Skeletal Muscle: Exercise and Aging

AMPK agonist AICAR improves cognition and motor coordination in young and aged mice

Nutrition, Nitrogen Requirements, Exercise and Chemotherapy-Induced Toxicity in Cancer Patients. A puzzle of Contrasting Truths?

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