MORPHOMETRIC ANALYSIS OF SEROMUCOUS ACINI AND GRANULAR DUCTS OF SUBMANDIBULAR GLANDS FROM RATS (Rattus norvegicus) SUBMITTED TO EXPERIMENTAL CHRONIC ALCOHOLISM
“…Rats from the isocaloric group received a solution containing sucrose (290.5 g/L) instead of ethanol. Rats from the ethanol group received 20% (v/v) ethanol in their drinking water (adapted from Chan and Sutter, 1983;Tirapelli et al, 2003). All animals had free access to Purina Lab Chow\.…”
“…Rats from the isocaloric group received a solution containing sucrose (290.5 g/L) instead of ethanol. Rats from the ethanol group received 20% (v/v) ethanol in their drinking water (adapted from Chan and Sutter, 1983;Tirapelli et al, 2003). All animals had free access to Purina Lab Chow\.…”
“…The rats in the control and diabetic groups had access to drinking water ad libitum and those in the alcohol and diabetic-alcohol groups received 20% (v/v) ethanol in their drinking water for three weeks. These groups underwent a brief and gradual adaptation period: the rats received 5% ethanol in their drinking water in the first week, 10% in the second week, and 20% in the third week, beginning with the pilot after the third week of treatment 15 .…”
“…When administering labeled hormones and visualizing them by immunofluorescence in the parotid gland of mice epithelial cells resembling those in the granular ducts of the SMG were found (Kurabuchi et al, ). Tirapelli et al () described changes in the granular ducts occurring due to the impact of chronic intoxication with ethanol as well as determined the time dependence of these changes. The determination of the degree of damage to glandular tissue and the possibilities of its restoration after trophic artery ligation were presented in the works of Fujisawa and Aiyama ().…”
In the intralobular duct of the SMG in experimental DM dystrophic changes of different intensity occur in the granular and striated ducts on the 14th day and in the intercalated ducts only since the 42nd day of the experiment.
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