Morphology, Thermo-Mechanical Properties and Biodegradibility of PCL/PLA Blends Reactively Compatibilized by Different Organic Peroxides

Przybysz-Romatowska, Marta; Barczewski, Mateusz; Mania, Szymon; Tercjak, Agnieszka; Haponiuk, Józef T.; Formela, Krzysztof

doi:10.3390/ma14154205

Cited by 7 publications

(4 citation statements)

References 48 publications

(43 reference statements)

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“…A similar trend was observed for the PCL scaffolds (showing an 11.64% weight loss at day 5 for scaffolds with a 200 μm pore size and a 13.37% weight loss at day 5 for scaffolds with a 500 μm pore size), which exhibited the lowest degradation kinetics. This can be explained by the increase in the surface area exposed to the NaOH that accelerates the hydrolytic degradation and the release into the liquid medium of the ceramic particles previously bonded with the polymeric material [ 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 ]. Results also indicate that, for the same material composition, bone bricks degrade slower compared with rectangular scaffolds.…”

Section: Resultsmentioning

confidence: 99%

Accelerated Degradation of Poly-ε-caprolactone Composite Scaffolds for Large Bone Defects

et al. 2023

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This research investigates the accelerated hydrolytic degradation process of both anatomically designed bone scaffolds with a pore size gradient and a rectangular shape (biomimetically designed scaffolds or bone bricks). The effect of material composition is investigated considering poly-ε-caprolactone (PCL) as the main scaffold material, reinforced with ceramics such as hydroxyapatite (HA), β-tricalcium phosphate (TCP) and bioglass at a concentration of 20 wt%. In the case of rectangular scaffolds, the effect of pore size (200 μm, 300 μm and 500 μm) is also investigated. The degradation process (accelerated degradation) was investigated during a period of 5 days in a sodium hydroxide (NaOH) medium. Degraded bone bricks and rectangular scaffolds were measured each day to evaluate the weight loss of the samples, which were also morphologically, thermally, chemically and mechanically assessed. The results show that the PCL/bioglass bone brick scaffolds exhibited faster degradation kinetics in comparison with the PCL, PCL/HA and PCL/TCP bone bricks. Furthermore, the degradation kinetics of rectangular scaffolds increased by increasing the pore size from 500 μm to 200 μm. The results also indicate that, for the same material composition, bone bricks degrade slower compared with rectangular scaffolds. The scanning electron microscopy (SEM) images show that the degradation process was faster on the external regions of the bone brick scaffolds (600 μm pore size) compared with the internal regions (200 μm pore size). The thermal gravimetric analysis (TGA) results show that the ceramic concentration remained constant throughout the degradation process, while differential scanning calorimetry (DSC) results show that all scaffolds exhibited a reduction in crystallinity (Xc), enthalpy (Δm) and melting temperature (Tm) throughout the degradation process, while the glass transition temperature (Tg) slightly increased. Finally, the compression results show that the mechanical properties decreased during the degradation process, with PCL/bioglass bone bricks and rectangular scaffolds presenting higher mechanical properties with the same design in comparison with the other materials.

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Section: Resultsmentioning

confidence: 99%

Accelerated Degradation of Poly-ε-caprolactone Composite Scaffolds for Large Bone Defects

et al. 2023

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“…To optimise the mechanical properties of PLLA and PLLA/PCL blend and obtain flexible composites, many works have been devoted to enhancing the compatibility using 'plasticiser'. [162][163][164][165][166][167] Na et al displayed that a given content of PCL-b-PEG could be a good compatibiliser in immiscible PLLA/PCL blends and lead to better PCL droplet morphologies with improved ductility. 168 Vilay et al also showed that the existence of 2 wt% PEG-polypropylene glycol-PEG triblock copolymer increased not only the ductility and impact strength but also the stiffness and tensile strength of PLLA.…”

Section: Blendingmentioning

confidence: 99%

“…Only the blend of PLLA/PCL (90/10 wt%) was miscible and possessed the best ductility and toughness. To optimise the mechanical properties of PLLA and PLLA/PCL blend and obtain flexible composites, many works have been devoted to enhancing the compatibility using ‘plasticiser’ 162–167 . Na et al displayed that a given content of PCL‐ b ‐PEG could be a good compatibiliser in immiscible PLLA/PCL blends and lead to better PCL droplet morphologies with improved ductility 168 .…”

Section: Modification Of Pllamentioning

confidence: 99%

Mechanical and gas permeability properties of poly(L‐lactic acid)–based films and their application in fresh produce preservation—Review

Yun,

Liu,

et al. 2024

Packag Technol Sci

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Plastics have remained the best choice for fruit and vegetable packaging due to their exceptional transparency, flexibility, optional good barrier and cost‐effectiveness. However, a large number of plastics end up in the environment after serving their intended purpose and persist there for centuries. Since worldwide attention to environmental issues has become an irreversible historical trend, cost‐effective renewable biodegradable packaging material is highly desirable for the packaging industry to satisfy both industrial demands as well as consumer expectations. Poly (L‐lactic acid) (PLLA), a renewable biodegradable polymer derived from biomass, has been widely studied as a very attractive polymer for food packaging applications. However, its brittle nature and medium CO2/O2 permeability are not friendly for its utilisation in the aspect of fresh agricultural products packaging. In such a context, great efforts have been devoted to improvements in the mechanical and permeability of PLLA to meet the requirements of food packaging. The main purpose of the review is to summarise the mechanical and permeability properties of composite films developed by the incorporation of toughness reinforcing agents into the PLLA matrix. The elongation at break of PLA can be increased up to 250 times by modification, and the CO2 permeability of PLA can be increased by 2–3 times by modification. We also elaborate on studies of the preservation effect of PLLA composite films on fresh fruits and vegetables.

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“…18 Several studies have reported the use of different proportions PLA and PCL blends as pure polymers in highly porous three-dimensional matrices for tissue regeneration, including various biomedical applications. [19][20][21][22] In the present study, we report an experimental investigation on the production of fibrous scaffolds, based on PLA and PCL blends, by rotary jet spinning. The blends were loaded with VAN to produce a scaffold that could be used to promote skin wound healing.…”

Section: Introductionmentioning

confidence: 99%

Poly (ε-caprolactone)/Poly (lactic acid) fibers produced by rotary jet spinning for skin dressing with antimicrobial activity

2022

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The rotary jet spinning technique permits the production of biomaterials that can be used as devices that come into contact with biological systems (including biological fluids) for diagnostic or surgical applications. These materials are composed of synthetic or natural compounds and allow the incorporation of drugs for therapeutic purposes. Two solutions containing 50% poly(lactic acid) (PLA) and 50% poly(ε-caprolactone) (PCL) diluted in three different solvents were prepared for rotary jet spinning (RJS) process. Vancomycin, an antibiotic indicated for the treatment of severe staphylococcal infections in patients with penicillin allergy, was added in the polymer solutions, to obtain drug-loaded fibrous mats. Morphological surface characterization by scanning electron microscopy revealed heterogeneous pores in the microfibers. Vancomycin loading interfered with the morphology of all samples in terms of fiber size, leading to smaller diameter fibers. Attenuated total reflectance/Fourier transform infrared spectroscopy was used for identification of the samples. The vibrational characteristics of PCL/PLA and vancomycin were consistent with expectations. Vero cell culture assays by the extract dilution and direct contact methods revealed the absence of cytotoxicity, except for the sample prepared with 50% of PCL and of a 9/2 (V/V) vancomycin content, with the growth of confluent and evenly spread cells on the fibrous mats surface. Microbiological analysis, performed on Staphylococcus aureus by the halo inhibition test and by the broth dilution method, showed that the antibacterial activity of vancomycin was maintained by the loading process in the polymer fibers. The results showed that rotary jet spinning produces satisfactory amounts of Vancomycin-loaded fibers, as potential web dressing for wound repair

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Morphology, Thermo-Mechanical Properties and Biodegradibility of PCL/PLA Blends Reactively Compatibilized by Different Organic Peroxides

Cited by 7 publications

References 48 publications

Accelerated Degradation of Poly-ε-caprolactone Composite Scaffolds for Large Bone Defects

Accelerated Degradation of Poly-ε-caprolactone Composite Scaffolds for Large Bone Defects

Mechanical and gas permeability properties of poly(L‐lactic acid)–based films and their application in fresh produce preservation—Review

Poly (ε-caprolactone)/Poly (lactic acid) fibers produced by rotary jet spinning for skin dressing with antimicrobial activity

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