Morphology of Corneal Basal Epithelial Cells by In Vivo Slit-Scanning Confocal Microscopy

Abstract

Corneal basal epithelial cell density and area were found to be remarkably consistent in the variety of corneal disorders that we examined. This finding is further evidence that this aspect of corneal epithelial cell differentiation and maturation is tightly controlled with little variability between individuals even if a corneal condition is present.

Effect of Autologous Serum Eye Drops in Patients with Sjögren Syndrome-related Dry Eye: Clinical and In Vivo Confocal Microscopy Evaluation of the Ocular Surface

“…Finally, another finding was that the thickness of the cornea was significantly reduced in our patients with DE disease, as in previous literature (6,7,40,(46)(47)(48). These changes occur for keratoconjunctivitus sicca in general (47) and for keratoconjunctivitus sicca combined with autoimmune disease (5,36).…”

“…The bead-like formations are characteristic of metabolically active nerve fibers containing transmitters, and the increased number found in DE disease cases indicates an attempt to improve the abnormal epithelial tropism (34,36,37,40). The chronic inflammation and diminished volume and clearance of tears enriched with pro-inflammatory cytokines such as interleukin (IL)-1 and IL6 lead to the activation of keratocytes, which synthesize nerve growth factor and other factors of nerve growth.…”

The effect of long-term wear of soft lenses of low and high oxygen transmissibility on the corneal epithelium

“…For those subjects, previous low Dk daily wear was considered equivalent to half a year of extended wear. On the basis of this, total wear experience for the low Dk group was 14 (4) years (range: [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22]. Four low Dk subjects wore lenses on a 13 nights/week extended wear schedule with fortnightly replacements.…”

“…4,7 The technique of confocal microscopy 18 allows for observations of the basal epithelium in vivo. 19 Therefore, the purpose of this study was to measure the effect of long-term wear of soft lenses on the corneal epithelium, most particularly on the in vivo basal epithelial appearance.…”

In Vivo Confocal Microscopic Evaluation of Cells and Nerve Fibers of the Healthy Human Cornea

“…5699±604 hücre/mm 2 olarak bildirmişler-dir. [9][10][11] Bu çalışmada ise ortalama bazal epitel hücre dansitesi 5846±393 hücre/mm 2 olarak ölçülmüştür. Çeşitli çalışmalarda yayınlanan hücre dansiteleri arasındaki farklılıklar, kullanılan konfokal mikroskopların çalışma prensiplerinin farklı olmasına bağlı olabilmektedir.…”