Effect of Autologous Serum Eye Drops in Patients with Sjögren Syndrome-related Dry Eye: Clinical and In Vivo Confocal Microscopy Evaluation of the Ocular Surface

Semeraro, Francesco; Forbice, Eliana; Taglietti, Marco; Romano, Vito; Guerra, Germano; Costagliola, Ciro

doi:10.21873/invivo.11016

Cited by 31 publications

(16 citation statements)

References 36 publications

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“…Four [24][25][26][27] of the seven studies reported Schirmer I test and all of them showed an increase in tear secretion. Nevertheless, the combined results revealed no significant difference.…”

Section: Discussionmentioning

confidence: 99%

Autologous Serum Eye Drops versus Artificial Tear Drops for Dry Eye Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

et al. 2019

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Objective: To compare the efficacy of autologous serum (AS) eye drops and artificial tears (AT) in dry eye disease (DED). Methods: Five databases (PubMed, Science Direct, the Cochrane Library, the Chinese National Knowledge Infrastructure, and the Wanfang Database) were searched for randomized controlled trials (RCTs). Efficacy was evaluated in terms of the Ocular Surface Disease Index (OSDI), Schirmer I test, tear break-up time (TBUT), and fluorescein and rose bengal staining of ocular surface. The estimated effects of AS or AT were expressed as a proportion with the 95% confidence interval and plotted on a forest plot. Results: Seven RCTs with 267 subjects were included in the meta-analysis. For most of the studies, subjects' age was around 50 years old, and the mostly treatment duration was within 8 weeks. The followup results showed that the OSDI after AS treatment was lower than that after the AT treatment: the mean difference (MD) was-10.75 (95% CI,-18.12;-3.39) points. There was no difference on the Schirmer I test after treatment between the two groups: the MD was 1.68 (95% CI,-0.65; 4.00) mm. The TBUT of the AS group was longer than that of the AT group, with an MD of 4.53 (95% CI, 2.02; 7.05) s. There was no statistically significant difference on fluorescein staining score of the ocular surface between the AS group and the AT group, the MD was-2.53 (95% CI,-6.08; 1.03) points. The rose bengal staining score of the AS group was slightly lower than that of the AT group after treatment: the MD was-0.78 (95% CI,-1.34;-0.22) points. Conclusion: AS could be an effective treatment for DED, improving OSDI, TBUT, and rose bengal staining score. Further RCTs with large samples and longterm follow-up are still needed to determine the exact role of AS in the management of DED.

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Section: Discussionmentioning

confidence: 99%

Autologous Serum Eye Drops versus Artificial Tear Drops for Dry Eye Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

et al. 2019

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“…The OSDI consists of 12 questions on symptoms within the past week and yields scores ranging from 0 (least severe) to 100 (most severe). A score of 12 is typically used as a cutoff for normal, 13-22 for mild dry eye, 23-32 for moderate dry eye, and ≥33 for severe dry eye (1,2,9).…”

Section: Methodsmentioning

confidence: 99%

Tear Film Osmolarity in Subjects with Acute Allergic Rhinoconjunctivitis

Nitoda

Lavaris

Laios

et al. 2018

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Abstract. Background/Aim: Acute allergic rhinoconjuctivitis is the most common form of ocular allergies. The pathogenetic mechanisms are based on an immunoglobulin E (IgEAcute allergic rhinoconjuctivitis is the most common form of ocular allergies, affecting at least 15-20% of the population. It is divided into seasonal (hay fever), which is released by pollen in the spring and summer, and perennial, which appears throughout the year and is induced by dust mites, animal dander and mold allergens (1, 2). The pathogenetic mechanisms of acute allergic conjunctivitis are based on an immunoglobulin E (IgE)-mediated hypersensitivity reaction, where IgE binds initially to highaffinity receptors on mast cells and basophils and then to the aforementioned allergens. The subsequent activation of mast cells results in the release of inflammatory mediators, including histamine, tryptase, prostaglandins, chemokines and leukotrienes (1). Monocytes, eosinophils and platelets also afford low-affinity IgE receptors (2). Subjects experience acute episodes of redness, tearing, ocular and nasal itching, sneezing, congestion and rhinorrhoea. Slit lamp examination usually reveals bilateral eyelid edema along with conjunctival swelling, chemosis and papillary reaction (1, 2). 403

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“…Human serum is similar to natural tears and contains many important components as: (1) epithelial growth factor EGF (acceleration of epithelial cell migration and antiapoptotic effects); (2) transforming growth factor-ß/TGF-ß (involved in the epithelial and stromal repair process); (3) vitamin A (prevent epithelial squamous metaplasia and modulate the expression of thrombospondin-1); (4) thrombospondin-2, vascular endothelial growth factor A/VEGF-A, metallopeptidase-9 which with TGF-ß promote wound healing; (5) albumin (anti-apoptotic activity); (6) α-2 macroglobulin (exhibits anti-collagenase activity); (7) fibronectin (involved in cell migration); (8) substance P and insulin-like growth factor (potential role in corneal epithelial migration and adhesion); and (9) immunoglobulins and lysozyme (bactericidal and bacteriostatic effect). Significant improvement in symptoms, fluorescein TFBUT, and ocular surface staining score were reported after autologous serum drops treatment [28,54,[80][81][82]. However, some studies reported no significant advantage in tear film stability, Schirmer test, or fluorescein staining in the use of AS over AF [83][84][85].…”

Section: Autologous Serummentioning

confidence: 99%

“…However, some studies reported no significant advantage in tear film stability, Schirmer test, or fluorescein staining in the use of AS over AF [83][84][85]. It is free of preservatives and has osmolarity and biomechanical properties similar to natural tears [54,80,84].…”

Section: Autologous Serummentioning

confidence: 99%

Sjögren’s Syndrome as an Ocular Problem: Signs and Symptoms, Diagnosis, Treatment

Kopacz¹,

Maciejewicz²

2019

Chronic Autoimmune Epithelitis - Sjogren's Syndrome and Other Autoimmune Diseases of the Exocrine Glands

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Sjögren's syndrome (SS) is an autoimmune disease of exocrine glands, which is characterized by dry mouth and dry eye, though ocular disturbances, such as dry eye disease, may be the first sign of the problem. In pathogenesis of SS, activated T-cells and B-cells infiltrate the lacrimal glands and autoimmune process leading to cell destruction. This process causes hyposecretion of tears and aqueous-deficient dry eye disease. Evaporative dry eye disease is connected with Meibomian gland dysfunction (MGD) and/or goblet cell loss. There are many questionnaires and tests to dry eye disease diagnosing, but there is no "gold standard." Correlation of data from symptom questionnaires and results of ocular staining score, Schirmer test I (without anesthesia), and break-up-time make it easier to diagnose. The treatment of SS includes both local (tear drops and moistures) and systemic (nonsteroidal anti-inflammatory drugs-NSAIDs, glucocorticoids, and disease-modifying antirheumatic drugs-biologics) therapies, but it is individual. We would like to present recent data on the ocular involvement and perspective of dry eye disease diagnosis and treatment in patients with SS.

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Effect of Autologous Serum Eye Drops in Patients with Sjögren Syndrome-related Dry Eye: Clinical and In Vivo Confocal Microscopy Evaluation of the Ocular Surface

Abstract: Abstract. Aim: To evaluate in vivo changes after therapy using autologous serum (AS) eye drops in

Cited by 31 publications

References 36 publications

Autologous Serum Eye Drops versus Artificial Tear Drops for Dry Eye Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Autologous Serum Eye Drops versus Artificial Tear Drops for Dry Eye Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Tear Film Osmolarity in Subjects with Acute Allergic Rhinoconjunctivitis

Sjögren’s Syndrome as an Ocular Problem: Signs and Symptoms, Diagnosis, Treatment

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