Morphology of Cancer Cells

Koss, Leopold G.

doi:10.1007/978-3-642-65895-2_1

Cited by 6 publications

(5 citation statements)

References 282 publications

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“…Different types of Human papillomaviruses (HPV) are associated with a variety of oral lesions. So far, HPV types 1,2,4,6,7,11,13,16, 18, 32 and 57 have been identified in oral lesions. Immunosuppression predisposes oral mucosa to clinical manifestations of different virus infections including HPV.…”

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Two different human papillomavirus (HPV) types associated with oral mucosal lesions in an HIV‐seropositive man

Syrjänen

Krogh

Kellokoski

et al. 1989

J Oral Pathology Medicine

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Different types of Human papillomaviruses (HPV) are associated with a variety of oral lesions. So far, HPV types 1, 2, 4, 6, 7, 11, 13, 16, 18, 32 and 57 have been identified in oral lesions. Immunosuppression predisposes oral mucosa to clinical manifestation of different virus infections including HPV. We describe here a 30-year-old HIV-positive and immunosuppressed man, who had suffered from oral lesions for a few months. On clinical examination, a nodular elevation was detected on the lower lip, and white keratotic areas were present on buccal mucosa bilaterally. A biopsy from the lip revealed the presence of acanthosis with a prominent granular cell layer as well as hyperparakeratosis. A biopsy from the buccal lesion showed a comparatively much flatter lesion with merely basal cell hyperplasia associated with hyperparakeratosis. Koilocytosis was a characteristic feature in both biopsies. In Southern blot hybridization, both lesions hybridized with a probe cocktail comprising HPV 6, 11, 16, 18, 31 and 33 DNA under low stringency. Under high stringency, the lip lesion proved to contain HPV 7 DNA, which also confirmed by in situ hybridization. The buccal lesion was weakly positive by Southern blot with HPV 11 and 13 probes hybridized under stringent conditions, but the restriction patterns with Pst I and Bam HI did not fit with those of any of the 57 HPV types known so far. In situ hybridizations with HPV 11 and HPV 13 probes were negative. Cloning of this 'new' HPV type is currently under way.

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“…In 1956, Koss et al described a special cellular change in cervical squamaous epithelium, which they termed koilocytosis (1). Koilocytosis is characterized by the occurrence the intermediate and superficial epithelial layers of cells exhibiting vacuolization as well as distinct nuclear changes including enlargement and hyperchromasia.…”

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confidence: 99%

Two different human papillomavirus (HPV) types associated with oral mucosal lesions in an HIV‐seropositive man

Syrjänen

Krogh

Kellokoski

et al. 1989

J Oral Pathology Medicine

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“…Relations between Aberdeen and Delane and Reeve were sufficiently close to elicit protests from other journals and newspapers, which were denied comparable advantage. In November 1842, The Times labelled Palmerston as a warmonger after he criticized Aberdeen's entente cordiale with France. This is not to say that Delane was completely in Aberdeen's pocket.…”

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Pressing the French and defending the Palmerstonian line: Lord William Hervey andThe Times, 1846-8

Guymer¹

2013

Hist Res

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This article uses the Spanish marriages episode of 1846 as a prism through which to examine the relationship between the leading foreign affairs writers for the increasingly powerful Times newspaper and the authors and servants of British diplomacy in the early Victorian period. The focus of this study is Lord William Hervey, the first secretary of the British embassy in Paris, a diplomat who well understood the power of the press over ministers, parliament and the people. Hervey's under‐utilized private papers shed light on the divisions in British political and literary (press) society over the nation's policies towards France and Spain. They also paint a picture of an increasingly isolated foreign secretary, Viscount Palmerston, a Whig statesman who failed to carry his policy through the Whig cabinet and who failed to convince the Conservative Times of its supposed merits, despite the support of some overactive members of the British diplomatic community. This is a story of diplomatic failure; a rare study of how not to win friends and influence people.

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“…Further investigations have been made for five cell types with K = 2(Koss 1974), nine cell types of mouse with K = 1 ( SHEA and LEBLOND 1966), nine different met abolic states of rat liver cells ( K = 1, MIRONESCU and DRAGOMIR 1966), seven different states of development of human oocytes (K=1,STAHL and LUCIAN 1972), and for other cell types (.MEINDER.S-GROENEVELD and JAMES 1971,PETERSEN and THERKELSEN 1962, SCHLEICHER et al 1976). All these investigations have been shown that the pN can be described sufficiently by means of the generalized Poisson model wSth the two parameters K and B.Zuaammen faaeung In dieser Arbeit werden die mittlere Nukleolenanzahl m von Zellkernen und die relative Hiiufigkeit p~ von Zellkernen mit N Nukleolen untereucht.…”

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confidence: 99%