Morphology Controlled Growth of Chitosan‐Bound Microtubes and a Study of their Biocompatibility and Antibacterial Activity

Abstract

Self-assembled peptide microtubes are fabricated with the biopolymer chitosan. The microtubes are covalently attached to chitosan and the morphology of the chitosan assembled on the surface of the microtubes can be tuned by altering the pH of the growth solution. Cytotoxicity studies in the presence of mouse embryonic fibroblasts indicate that the chitosan-bound microtubes are highly biocompatible and the cells are able to survive and proliferate at a similar rate to the control. Antibacterial studies in the presence of E. coli prove that the chitosan-bound microtubes are bactericidal. This simple method for the development of biocompatible microstructures will facilitate cell targeting, fabrication of efficient carrier devices, and the preparation of highly efficient antibacterial materials.

Micro- and Nanoscale Hydrogel Systems for Drug Delivery and Tissue Engineering

“…Other natural materials such as chitosan and ovalbumin have also been used to synthesize nanogels that can be utilized in drug delivery systems [115]. It is well known that chitosan and its derivatives are elastomeric, biocompatible, antibacterial and resorbable [116,117,118,119]. The benefits of such nanogel spheres include having the biomedical assets of chitosan as well as the ability to synthesize these particles in a green way that does not require separation during preparation.…”

Gallium nitride porous microtubules self-assembled from wurtzite nanorods

“…However, it is challenging to synthesize microtubular structures with quantum effects. Various microscaled hollow tubular structures have been synthesized without templates, such as element microtubes (gold microtubes [16], selenium microtubes [17], tellurium microtubes [18,19], silicon microtubes [20], and carbon microtubes [21]), surfide microtubes (ZnS [22], MoS 2 [23], and PbS [24]), oxides microtubes (ZnO [25][26][27] and Al 18 B 4 O 33 [28]), borate microtubes (AlB [29]), pharmaceutical microtubes [30], and organic microtubes [31][32][33]. The crystalline size of the constituent nanostructures, as well as the walls of these microtubes, were several hundred nanometers to several microns in diameter.…”

Biocompatible Surface-Coated Probe for in Vivo, in Situ, and Microscale Lipidomics of Small Biological Organisms and Cells Using Mass Spectrometry

“…27,28 Previous cytotoxicity study has demonstrated that chitosan-based materials were nontoxic, highly biocompatible, and suitable for in vivo investigation. 29 The chitosan polymer coating allows lipid species to enter the interior absorbent but prevents biological cells to pass through the coating via size exclusion, 28 enhancing the biocompatibility and anti-interference ability of SPME probe for sampling complex biological samples. The obtained biocompatible surface-coated SPME probe processes a tip-end diameter of less than 5 μm (Figure 2a).…”