Micro- and Nanoscale Hydrogel Systems for Drug Delivery and Tissue Engineering

Schwall, Christine T.; Banerjee, Ipsita A.

doi:10.3390/ma2020577

Cited by 77 publications

(55 citation statements)

References 156 publications

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“…Conventional hydrogels are crosslinked polymer chains that absorb water from an aqueous medium and registered no variation in their swelling equilibrium with the change in pH, temperature or electric field of the surrounding environment, whereas stimuli responsive hydrogels are polymeric networks that modify their swelling equilibrium with the change of the external environment (Pal et al 2009). Smart, intelligent or stimuli-sensitive materials can be either of synthetic or of natural origin (Goycoolea et al 2003;Schwall and Banerjee 2009). Polysaccharides like CH and cellulose derivatives are representative examples of stimuli-sensitive biomaterials.…”

Section: Introductionmentioning

confidence: 99%

Thermo-sensitive chitosan–cellulose derivative hydrogels: swelling behaviour and morphologic studies

et al. 2014

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Hydrogels are three-dimensional, hydrophilic, polymer networks that are able to imbibe large amounts of water or biological fluids, while maintaining their dimensional stability. The polymer binding might be achieved by chemical or physical interactions. Physical crosslinking of a polymer to form its hydrogel, might be accomplished either by casting-solvent evaporation (SC) method or by freeze-thaw (FT) technique. The physical hydrogels, especially the ones based on natural biopolymers, like polysaccharides, are being widely used in industry and medicine due to their favourable properties: biocompatibility; biodegradability; low toxicity and eco-friendly characteristics. Polysaccharides, like chitosan (CH) and (hydroxypropyl)methyl cellulose (HPMC) have gained great attention due to its stimuli sensitive properties: pH and temperature responsiveness, respectively. Thus, within this work we have developed physically crosslinked CH:HPMC hydrogel films, using both SC and FT techniques. The attained CH:HPMC membranes were evaluated in terms of their swelling, thermal (low critical solution temperature-LCST), structural (attenuated total reflectance Fourier transform infrared spectroscopy) and morphological (scanning electron microscopy and atomic force microscopy) properties. According to these results, the developed membranes exhibit a good miscibility between the two component biopolymers. Moreover, the CH:HPMC membranes exhibit a high swelling capacity (SW FT = 1,172 and SW SC = 7,323), a low surface roughness (Sq = 5.6-9.5 nm) and an elevated LCST (LCST = 85.2-87.5°C). The stimuli sensitive behaviour makes hydrogels appealing for the design of smart devices applicable in a variety of technological fields. In our particular case, we envisage the application of such materials as active substances (moisturisers, antiperspirants and scents) delivers, into textile substrates in a controlled manner.

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Section: Introductionmentioning

confidence: 99%

Thermo-sensitive chitosan–cellulose derivative hydrogels: swelling behaviour and morphologic studies

et al. 2014

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“…[1][2][3][4][5][6][7][8][9][10] The thermal response of PNIPAM originates from the coil-to-globule phase transition that takes place on heating of an aqueous solution of the polymer. [ 11 ] The process occurs upon crossing a critical temperature and leads to phase separation readily detectable by optical methods.…”

Section: Introductionmentioning

confidence: 99%

Coil‐to‐Globule Transition of Poly(N‐isopropylacrylamide) in Aqueous Solution: Kinetics in Bulk and Nanopores

Farasat

Vyazovkin

2014

Macro Chemistry & Physics

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Differential scanning calorimetry (DSC) is used to study the kinetics of the coil-to-globule transition in aqueous solutions of poly( N -isopropoylacrylamide) (PNIPAM) prepared in the bulk (3 and 10 wt%) and nanoconfi ned (10 wt% inside 30 nm silica pores) forms. It is demonstrated that the kinetics can be described in terms of the classical nucleation model. The proposed treatment affords estimating the free-energy barrier and pre-exponential factor of the transition. The application of the nucleation model to the DSC data collected for the three systems studied provides physical insights into the effect of increasing the transition temperature due to dilution and nanoconfi nement. Dilution appears to raise the free-energy barrier, whereas nanoconfi nement causes a decrease in the pre-exponential factor. demixing of a two component mixture having the lower critical solution temperature. Per this treatment, raising temperature above the binodal (equilibrium) line brings the system into a metastable state that demixes (relaxes) via the process of nucleation, i.e., the formation of tiny droplets of a new phase. The process is relatively slow as it requires overcoming a thermodynamic free-energy barrier associated with the surface energy of the forming droplet.Notwithstanding a plethora of publications dealing with the coil-to-globule transition in PNIPAM, rather few of them [15][16][17][18][19][20][21][22][23][24] are devoted specifi cally to its kinetics. Surprisingly, we have not been able to fi nd any publications that would attempt to parameterize the kinetics of the coil-to-globule transition in the frameworks of a nucleation model. Such an attempt is made in this paper that combines the classical nucleation kinetics model [ 13,14 ] with isoconversional kinetic analysis [ 25,26 ] and applies them to calorimetric data on the coil-to-globule transition 305 306 307 0 10 20 30 40 50 10% 3% Silica

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“…For example, Tam et al recently reported the preparation of biocompatible zwitterionic microgel systems synthesized from chitosan, carboxymethyl cellulose, and modified methyl cellulose polymerized via an inverse microemulsion technique for the fast response drug release of procaine hydrochloride [21]. Aside from directly utilizing the responsiveness of the prepared zwitterionic microgel particles for the uptake and release of therapeutic drugs [22], there has been little reported on their ability for the environmental stimuli triggered adsorption and desorption of active chemical solutes, such as macromolecular surfactants. Some earlier efforts have been made to examine the effect of varying surfactant concentrations during polyelectrolyte microgel synthesis [23,24] as well as the interaction of surfactant molecules with microgel particles [25][26][27].…”

Section: Introductionmentioning

confidence: 98%

Adsorption and release of surfactant into and from multifunctional zwitterionic poly(NIPAm-co-DMAPMA-co-AAc) microgel particles

Chen

Kelley

Guo

et al. 2015

Journal of Colloid and Interface Science

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Micro- and Nanoscale Hydrogel Systems for Drug Delivery and Tissue Engineering

Cited by 77 publications

References 156 publications

Thermo-sensitive chitosan–cellulose derivative hydrogels: swelling behaviour and morphologic studies

Thermo-sensitive chitosan–cellulose derivative hydrogels: swelling behaviour and morphologic studies

Coil‐to‐Globule Transition of Poly(N‐isopropylacrylamide) in Aqueous Solution: Kinetics in Bulk and Nanopores

Adsorption and release of surfactant into and from multifunctional zwitterionic poly(NIPAm-co-DMAPMA-co-AAc) microgel particles

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