Morphology and Properties of Spray‐Dried Particles

Presence of Electrostatically Adsorbed Polysaccharides Improves Spray Drying of Liposomes

“…The low molecular weight maltodextrin stays mobile through most of the drying, while the high molecular weight maltodextrin will not be able to shrink in the later phase and the skin rather wrinkles. The inverse relationship between surface dents and DE values of maltodextrins in our study is thus in agreement with the findings of various other authors (Sheu and Rosenberg ; Danviriyakul and others ; Walzel and Furuta ).…”

“…Depending on the evaporation speed and the rate with which the solvent may migrate from the interior to the surface, solids may precipitate from the solution at the surface of the particles, leading to the formation of a crust or skin. Depending on the mechanical properties of the developing skin, it may remain intact or may fracture (Walton ; Walzel and Furuta ). Moreover, if the drying process takes place at a high temperature, the crust development may be followed by an internal bubble formation.…”

The use of albumin solid dispersion to enhance the solubility of unionizable drugs

“…The surface morphology of spray dried powder displayed rounded and smooth microparticles with a size ranging between 0.3 and 3 µm and a single hole at the surface (Fig.1c). The formation of this single indentation on particles surface could be explained by the outbreak of the skin-like outer shell formed on the droplet surface due to high pressure generated during the heating process (Khoder et al, 2016, Walzel andFuruta 2011). Unprocessed PRD displayed a poor solubility in water that could be attributed to its crystalline state ( Fig.…”

Efficient approach to enhance drug solubility by particle engineering of bovine serum albumin

“…As a result, a considerable rise in temperature and vapour pressure takes place inside the particle until the formed skin-like shell cracks open to allow vapour escaping. This results in a sudden under-pressure within the particle cavity causing the shell indentation (Walzel and Furuta, 2011). In the case of SDsus microparticles, the presence of dispersed insoluble particles in the droplet renders the crust formed by drying process more diffusible (Fig.…”

“…This produces a permeable outer layer allowing a progressive evaporation of the liquid. As a result, the drying process, progressing from the outer shell, reduces the size of the droplet steadily and this leads to the absence of holes in smaller size microparticles (Walzel and Furuta, 2011).…”